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Entry version 57 (05 Jun 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

ATP7B

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi122PROSITE-ProRule annotation1
Metal bindingi125PROSITE-ProRule annotation1
Metal bindingi207PROSITE-ProRule annotation1
Metal bindingi210PROSITE-ProRule annotation1
Metal bindingi321PROSITE-ProRule annotation1
Metal bindingi324PROSITE-ProRule annotation1
Metal bindingi423PROSITE-ProRule annotation1
Metal bindingi426PROSITE-ProRule annotation1
Metal bindingi552PROSITE-ProRule annotation1
Metal bindingi555PROSITE-ProRule annotation1
Metal bindingi628PROSITE-ProRule annotation1
Metal bindingi631PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingUniRule annotation, Metal-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei709 – 728HelicalUniRule annotationAdd BLAST20
Transmembranei748 – 770HelicalUniRule annotationAdd BLAST23
Transmembranei782 – 808HelicalUniRule annotationAdd BLAST27
Transmembranei814 – 835HelicalUniRule annotationAdd BLAST22
Transmembranei980 – 1007HelicalUniRule annotationAdd BLAST28
Transmembranei1027 – 1047HelicalUniRule annotationAdd BLAST21
Transmembranei1382 – 1404HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000012531

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 178HMAInterPro annotationAdd BLAST67
Domaini197 – 263HMAInterPro annotationAdd BLAST67
Domaini311 – 371HMAInterPro annotationAdd BLAST61
Domaini413 – 479HMAInterPro annotationAdd BLAST67
Domaini542 – 608HMAInterPro annotationAdd BLAST67
Domaini618 – 677HMAInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni279 – 304DisorderedSequence analysisAdd BLAST26
Regioni379 – 405DisorderedSequence analysisAdd BLAST27
Regioni514 – 535DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi284 – 304PolarSequence analysisAdd BLAST21
Compositional biasi386 – 401PolarSequence analysisAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0207 Eukaryota
COG2217 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155749

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1LZM3

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSWISGT

TreeFam database of animal gene trees

More...
TreeFami
TF300460

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00371 HMA, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00403 HMA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
TIGR00003 TIGR00003, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1LZM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEAGSETPG SPEPSFLATL GDPQVTLVSV HKRWSFRRNP GARGSTRPVT
60 70 80 90 100
SEEEEEFAQK VLNGARGIRS NQILSKLSLP TRAWEPEMKQ SFAFDNVGYE
110 120 130 140 150
GGLDGACPPQ TTSTVSVSGM TCQSCVQSIE GRISSLKGVV SIKVSLEQGS
160 170 180 190 200
ATVTYVPSIL SLPQICHHIE DMGFEASVAE GKAASWPSRS SSGLEAVVKL
210 220 230 240 250
RVEGMTCQSC VSSIEGKLGK LQGVVRVRVS LGTQEAVITY QPYLIQPQDL
260 270 280 290 300
RDHVNDMGFE AVIKNRVAPV SLGPIDIGRL QRTNPKTPLA SDNQNLNNSE
310 320 330 340 350
TSGHQGSHVV TLQLRIDGMH CKSCVLNIEE NIGQLPGVQS IQVSLENRMA
360 370 380 390 400
QVQYDPSRVT AGALQRAIEA LPPGNFKVSL PDGAEGSGTG SWSSNRVTPA
410 420 430 440 450
PDPRTQAPGV YETVVLAIAG MTCASCVQSI EGLISQREGV QQMSVSLAEG
460 470 480 490 500
TGVVLYDPAI INPEELRAAV EEMGFETSVI SGNCYSNHVG NHSAGNSSAC
510 520 530 540 550
PAAGVPASVQ EVAPHAGGLP KSHDPGSSSK PPQASTLGAP QKCFLQITGM
560 570 580 590 600
TCASCVSNIE RNLQKEAGIL SVLVALMAGK AEVKYNPEVI QPLEVARLIQ
610 620 630 640 650
DLGFEATVME DYTGTDGDLE LIIMGMTCAS CVHNIESKLT RTNGITYASV
660 670 680 690 700
ALATSKAHVK FDPEIIGPRD IVRIIENKEI GFHASPAQRN ADAHHLDHKV
710 720 730 740 750
EIKQWKKSFL CSLVFGIPVM GLMIYMLVPS NEPHESMVLD HNIIPGLSIL
760 770 780 790 800
NLIFFILCTF VQLLGGWYFY VQAYRSLRHR AANMDVLIVL ATSIAYSYSL
810 820 830 840 850
VILVVAVAEK AERSPVTFFD TPPMLFVFIA LGRWLEHVAK SKTSEALAKL
860 870 880 890 900
MSLQATEATV VTLGEDNLII REEQVPMELV QRGDIIKVVP GGKFPVDGKV
910 920 930 940 950
LEGNTMADES LITALGEAMP VTKKPGSTVI AGSINAHGSV LINATHVGND
960 970 980 990 1000
TTLAQIVKLV EEAQMSKAPI QQLADRFSGY FVPFIIIIST LTLVVWIIIG
1010 1020 1030 1040 1050
FIDFGVVQKY FPTPNKHISQ AEVIIRFAFQ TSITVLCIAC PCSLGLATPT
1060 1070 1080 1090 1100
AVMVGTGVAA QNGILIKGGK PLEMAHKIKT VMFDKTGTIT YGVPKVMRVL
1110 1120 1130 1140 1150
LLVDVATMPL RKVLAVVGTA EASSEHPLGV AVTKYCKEEL GTETLGYCTD
1160 1170 1180 1190 1200
FQAVPGCGIG CKVSSVEGIL AHSEHPQSKQ AAPPNTVGGI PEEIDATPQT
1210 1220 1230 1240 1250
FSVLIGNREW MRRNGLTISS DISDAMTDHE MKGQTAILVA IDGVLCAMFA
1260 1270 1280 1290 1300
IADAVKQEAA LAVHTLKSMG VDVVLITGDN RKTARAIATQ VGINKVFAEV
1310 1320 1330 1340 1350
LPSHKVAKVQ ELQNEGKKVA MVGDGVNDSP ALARADVGIA IGTGTDVAIE
1360 1370 1380 1390 1400
AADVVLIRND LLDVAASIHL SKRTVWRIRL NLVLALIYNL IGIPIAAGVF
1410 1420 1430 1440 1450
MPIGIVLQPW MGSAAMAASS VSVVLSSLQL KCYKKPDLER YEAQAQGRMK
1460 1470 1480 1490 1500
PLTASQVSVH IGMDDRRRDS PRATPWDQVS FISQVSLSSL KSDKLSRHSA
1510 1520
TAEDNGDKWS LLLNDRDEEQ CI
Length:1,522
Mass (Da):163,026
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4873CDF2F78F15C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01176725 Genomic DNA No translation available.
ACTA01184723 Genomic DNA No translation available.
ACTA01192721 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000013065; ENSAMEP00000012531; ENSAMEG00000011878

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01176725 Genomic DNA No translation available.
ACTA01184723 Genomic DNA No translation available.
ACTA01192721 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000012531

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000013065; ENSAMEP00000012531; ENSAMEG00000011878

Phylogenomic databases

eggNOGiKOG0207 Eukaryota
COG2217 LUCA
GeneTreeiENSGT00940000155749
InParanoidiG1LZM3
OMAiNSWISGT
TreeFamiTF300460

Family and domain databases

CDDicd00371 HMA, 6 hits
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 6 hits
SUPFAMiSSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
TIGR00003 TIGR00003, 4 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1LZM3_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1LZM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 5, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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