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UniProtKB - G1LSJ7 (G1LSJ7_AILME)

Entry version 47 (07 Apr 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

TUB like protein 4

Gene

TULP4

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TUB like protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Ursidae › Ailuropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9646.ENSAMEP00000010037

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini289 – 330SOCS boxInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 161DisorderedSequence analysisAdd BLAST20
Regioni466 – 491DisorderedSequence analysisAdd BLAST26
Regioni752 – 772DisorderedSequence analysisAdd BLAST21
Regioni865 – 936DisorderedSequence analysisAdd BLAST72
Regioni1230 – 1270DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi913 – 933PolarSequence analysisAdd BLAST21
Compositional biasi1236 – 1265PolyampholyteSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2503, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002083_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1LSJ7

Identification of Orthologs from Complete Genome Data

More...OMAi		CRNNMNP

TreeFam database of animal gene trees

More...TreeFami		TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001496, SOCS_box
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01167, Tub, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50225, SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1LSJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VVLVRWNEPY QKLATCDADG GIFVWIQYEG RWSVELVNDR GAQVSDFTWS 
        60         70         80         90        100
HDGTQALISY RDGFVLVGSV SGQRHWSSEI NLESQITCGI WTPDDQQVLF 
       110        120        130        140        150
GTADGQVIVM DCHGRMLAHV LLHESDGILS MSWNYPAFLV EDSSESDTDS 
       160        170        180        190        200
DDYSPPQDGP AAYPIPVQNI KPLLTVSFTS GDISLMNNYD DLSPTVIRSG 
       210        220        230        240        250
LKEVVAQWCT QGDLLAVAGM ERQTQLGDLP NGPLLKSAMV KFYNVRGEHI 
       260        270        280        290        300
FTLDTLVQRP IVSICWGHRD SRLLMASGPA LYVVRVEHRV SSLQLLCQQA 
       310        320        330        340        350
IASALREDKD VSKLTLPPRL CSYLSTAFIP TIKPPIPDPN NMRDFVSYPS 
       360        370        380        390        400
AGNERLHCTM KRTEDDPEVG GPCYTLYLEY LGGLVPILKG RRISKLRPEF 
       410        420        430        440        450
VIMDPRTDSK SDEIYGNSLI SAMLDSCNCS DSSDVELSDD WAAKKSPKIS 
       460        470        480        490        500
RASKSPKLPR INIEARKSPK LSRAAQEMSR SPRLPMRKPS IGSPSLTRRE 
       510        520        530        540        550
FPFEDITQHN YLAQVTSNIW GTKFKIVGLA AFLPTSLGAV IYKTSLLHLQ 
       560        570        580        590        600
PRQMTIYLPE VRKISMDYVN LPVFNPNVFS EDEDDLPVTG ASGVPENNPP 
       610        620        630        640        650
CTVNIPIAPI HSSAQAMSPT QSIGLVQSLL ANQNVQLDVL TNQTTAVGTS 
       660        670        680        690        700
EHGSESATQY PVSNRYSNPG QVIFGGVEMG RIIPNPAQLS LPPPAQGAIQ 
       710        720        730        740        750
LSVVDHGDRD HDHLQKSTKA LRPVAQLAAE GDAVVFSAPQ EVQVAKMNPP 
       760        770        780        790        800
PPYPGTIPAA PTTAAPPPPL PPPQPPVDTC LKKGDFSLYP TAAHYQTPLG 
       810        820        830        840        850
YERITTFDSS GNVEEVCRPR TRMLCSQNTY TLPGPGSSAT LRLTATEKKV 
       860        870        880        890        900
PQPCTSATLN RLTVPRYSIP TGDPPPYPEI AGPLMPGRGA AQRPDSRPEP 
       910        920        930        940        950
GGGVGGAQPG SGLAHAASTS PLTSQSSYSL LSPTDGARDR ADYVNSAFTE 
       960        970        980        990       1000
DEALAQHCQV EKPLRHPALT EAAVAVKRPP PYQWDPVLGE DIWIPQERTA 
      1010       1020       1030       1040       1050
QTAVPNPLKL PPLIVGQSQH LDVSRVPFVS PKSPASPTAT FQTGYGMGMP 
      1060       1070       1080       1090       1100
YPGSYNTPPL PGVQTPCSPK DALAPTPFAP QESAVVLQPA YPPSLSYCTL 
      1110       1120       1130       1140       1150
PPMYPGSSTC SSLQLPPIAL HPWNSYSPCP PVQNPQGTLP PKAHLVVEKP 
      1160       1170       1180       1190       1200
LVSPPPTDLQ SHLGTEVMVE TTDNFQEVLS LTESPVPQRT EKFGKKNRKR 
      1210       1220       1230       1240       1250
LDSRAEEGNV QAITEGKVKK EARTLSDFNS LISSPRLGRE KKKVKSQKDQ 
      1260       1270       1280       1290       1300
LKSKKLNKTN EFQDSSESEP ELFISGDELM NQSQGSKKGW KSKRSLRTAS 
      1310       1320       1330       1340       1350
ELEEFKCRKA SEKEDGRLGS QGFVYVMANK QPLWNEATQV YQLDFGGRVT 
      1360       1370       1380       1390       1400
QESAKNFQIE LEGRQVMQFG RIDGNAYILD FQYPFSAVQA FAVALANVTQ 

RLK
Length:1,403
Mass (Da):153,364
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD276FA8EDB7A99D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
ACTA01160948 Genomic DNA No translation available.
ACTA01168946 Genomic DNA No translation available.
ACTA01176944 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSAMET00000010474; ENSAMEP00000010037; ENSAMEG00000009544

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01160948 Genomic DNA No translation available.
ACTA01168946 Genomic DNA No translation available.
ACTA01176944 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000010037

Genome annotation databases

EnsembliENSAMET00000010474; ENSAMEP00000010037; ENSAMEG00000009544

Phylogenomic databases

eggNOGiKOG2503, Eukaryota
GeneTreeiENSGT00940000155913
HOGENOMiCLU_002083_1_0_1
InParanoidiG1LSJ7
OMAiCRNNMNP
TreeFamiTF314076

Enzyme and pathway databases

UniPathwayiUPA00143

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496, SOCS_box
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167, Tub, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50225, SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1LSJ7_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1LSJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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