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Entry version 44 (17 Jun 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

TUB like protein 4

Gene

TULP4

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TUB like protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000010037

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini289 – 330SOCS boxInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 161DisorderedSequence analysisAdd BLAST20
Regioni466 – 491DisorderedSequence analysisAdd BLAST26
Regioni752 – 772DisorderedSequence analysisAdd BLAST21
Regioni865 – 936DisorderedSequence analysisAdd BLAST72
Regioni1230 – 1270DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi913 – 933PolarSequence analysisAdd BLAST21
Compositional biasi1236 – 1265PolyampholyteSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2503 Eukaryota
ENOG410YEKG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002083_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1LSJ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRNNMNP

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001496 SOCS_box
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR008983 Tumour_necrosis_fac-like_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01167 Tub, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit
SSF50978 SSF50978, 1 hit
SSF54518 SSF54518, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50225 SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1LSJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VVLVRWNEPY QKLATCDADG GIFVWIQYEG RWSVELVNDR GAQVSDFTWS
60 70 80 90 100
HDGTQALISY RDGFVLVGSV SGQRHWSSEI NLESQITCGI WTPDDQQVLF
110 120 130 140 150
GTADGQVIVM DCHGRMLAHV LLHESDGILS MSWNYPAFLV EDSSESDTDS
160 170 180 190 200
DDYSPPQDGP AAYPIPVQNI KPLLTVSFTS GDISLMNNYD DLSPTVIRSG
210 220 230 240 250
LKEVVAQWCT QGDLLAVAGM ERQTQLGDLP NGPLLKSAMV KFYNVRGEHI
260 270 280 290 300
FTLDTLVQRP IVSICWGHRD SRLLMASGPA LYVVRVEHRV SSLQLLCQQA
310 320 330 340 350
IASALREDKD VSKLTLPPRL CSYLSTAFIP TIKPPIPDPN NMRDFVSYPS
360 370 380 390 400
AGNERLHCTM KRTEDDPEVG GPCYTLYLEY LGGLVPILKG RRISKLRPEF
410 420 430 440 450
VIMDPRTDSK SDEIYGNSLI SAMLDSCNCS DSSDVELSDD WAAKKSPKIS
460 470 480 490 500
RASKSPKLPR INIEARKSPK LSRAAQEMSR SPRLPMRKPS IGSPSLTRRE
510 520 530 540 550
FPFEDITQHN YLAQVTSNIW GTKFKIVGLA AFLPTSLGAV IYKTSLLHLQ
560 570 580 590 600
PRQMTIYLPE VRKISMDYVN LPVFNPNVFS EDEDDLPVTG ASGVPENNPP
610 620 630 640 650
CTVNIPIAPI HSSAQAMSPT QSIGLVQSLL ANQNVQLDVL TNQTTAVGTS
660 670 680 690 700
EHGSESATQY PVSNRYSNPG QVIFGGVEMG RIIPNPAQLS LPPPAQGAIQ
710 720 730 740 750
LSVVDHGDRD HDHLQKSTKA LRPVAQLAAE GDAVVFSAPQ EVQVAKMNPP
760 770 780 790 800
PPYPGTIPAA PTTAAPPPPL PPPQPPVDTC LKKGDFSLYP TAAHYQTPLG
810 820 830 840 850
YERITTFDSS GNVEEVCRPR TRMLCSQNTY TLPGPGSSAT LRLTATEKKV
860 870 880 890 900
PQPCTSATLN RLTVPRYSIP TGDPPPYPEI AGPLMPGRGA AQRPDSRPEP
910 920 930 940 950
GGGVGGAQPG SGLAHAASTS PLTSQSSYSL LSPTDGARDR ADYVNSAFTE
960 970 980 990 1000
DEALAQHCQV EKPLRHPALT EAAVAVKRPP PYQWDPVLGE DIWIPQERTA
1010 1020 1030 1040 1050
QTAVPNPLKL PPLIVGQSQH LDVSRVPFVS PKSPASPTAT FQTGYGMGMP
1060 1070 1080 1090 1100
YPGSYNTPPL PGVQTPCSPK DALAPTPFAP QESAVVLQPA YPPSLSYCTL
1110 1120 1130 1140 1150
PPMYPGSSTC SSLQLPPIAL HPWNSYSPCP PVQNPQGTLP PKAHLVVEKP
1160 1170 1180 1190 1200
LVSPPPTDLQ SHLGTEVMVE TTDNFQEVLS LTESPVPQRT EKFGKKNRKR
1210 1220 1230 1240 1250
LDSRAEEGNV QAITEGKVKK EARTLSDFNS LISSPRLGRE KKKVKSQKDQ
1260 1270 1280 1290 1300
LKSKKLNKTN EFQDSSESEP ELFISGDELM NQSQGSKKGW KSKRSLRTAS
1310 1320 1330 1340 1350
ELEEFKCRKA SEKEDGRLGS QGFVYVMANK QPLWNEATQV YQLDFGGRVT
1360 1370 1380 1390 1400
QESAKNFQIE LEGRQVMQFG RIDGNAYILD FQYPFSAVQA FAVALANVTQ

RLK
Length:1,403
Mass (Da):153,364
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD276FA8EDB7A99D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01160948 Genomic DNA No translation available.
ACTA01168946 Genomic DNA No translation available.
ACTA01176944 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000010474; ENSAMEP00000010037; ENSAMEG00000009544

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01160948 Genomic DNA No translation available.
ACTA01168946 Genomic DNA No translation available.
ACTA01176944 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000010037

Genome annotation databases

EnsembliENSAMET00000010474; ENSAMEP00000010037; ENSAMEG00000009544

Phylogenomic databases

eggNOGiKOG2503 Eukaryota
ENOG410YEKG LUCA
GeneTreeiENSGT00940000155913
HOGENOMiCLU_002083_1_0_1
InParanoidiG1LSJ7
OMAiCRNNMNP
TreeFamiTF314076

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496 SOCS_box
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR008983 Tumour_necrosis_fac-like_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167 Tub, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
SSF50978 SSF50978, 1 hit
SSF54518 SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1LSJ7_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1LSJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 17, 2020
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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