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Entry version 39 (31 Jul 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Castor zinc finger 1

Gene

CASZ1

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Castor zinc finger 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASZ1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000007180

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini542 – 571C2H2-typeInterPro annotationAdd BLAST30
Domaini659 – 688C2H2-typeInterPro annotationAdd BLAST30
Domaini1448 – 1472C2H2-typeInterPro annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni51 – 73DisorderedSequence analysisAdd BLAST23
Regioni111 – 166DisorderedSequence analysisAdd BLAST56
Regioni369 – 416DisorderedSequence analysisAdd BLAST48
Regioni677 – 714DisorderedSequence analysisAdd BLAST38
Regioni880 – 921DisorderedSequence analysisAdd BLAST42
Regioni1065 – 1095DisorderedSequence analysisAdd BLAST31
Regioni1354 – 1383DisorderedSequence analysisAdd BLAST30
Regioni1580 – 1657DisorderedSequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 147PolyampholyteSequence analysisAdd BLAST28
Compositional biasi375 – 412Pro-richSequence analysisAdd BLAST38

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4377 Eukaryota
ENOG410XRBA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008187

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1LJS3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLHKVHF

TreeFam database of animal gene trees

More...
TreeFami
TF324787

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040373 CASZ1
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR12451 PTHR12451, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1LJS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SDLSVRPAAE STRCTDPPAG KPAMAAKRKG GLKLNAICAK LSRQVVVEKG
60 70 80 90 100
AEAGPPAQGS LGVARGARSE EDKRRAVIEK WVNGEYSEEP APVPSLGRIG
110 120 130 140 150
REGLELPPEG VYMVQPQGCS DEEDHGDEPP KDGSGVAEEK EPDGTASKDD
160 170 180 190 200
SGPGAKQASG EASSLRDYAA STMTEFLGMF GYDDQNTRDE LARKISFEKL
210 220 230 240 250
HPGSTPEVAT SSMLPASEDA LSKRARFSKY EEYIRKLKAG EQLSWPAHST
260 270 280 290 300
KAEERAGKEV AGPLPGLRLP SSTAHLETKA TILPLPSHSS VPMQGLVARA
310 320 330 340 350
SKYDFFIQKL KTGENLRPQN GSTYKKPSKY DLENVKYLHL FKPGEGSPDM
360 370 380 390 400
GGAIAFKTGK VGRPSKYDVR AIQKPGPPKV PPTPSLAPAP LPSVPSAPSA
410 420 430 440 450
PGPGPEPPAS LPFNTPEYLK STFSKTDSIT TGTVSTVKNG LPTDKPAVTE
460 470 480 490 500
DVNIYQKYIA RFSGSQHCGH IHCAYQYREH YHCLDPECNY QRFTSKQDVI
510 520 530 540 550
RHYNMHKKRD NSLQHGFMRF SPLDDCSVYY HGCHLNGKST HYHCMQVGCN
560 570 580 590 600
KVYTSTSDVM THENFHKKNT QLINDGFQRF RATEDCGTAD CQFYGQKTTH
610 620 630 640 650
FHCRRPGCTF TFKNKCDIEK HKSYHIKDDA YAKDGFKKFY KYEECRYEGC
660 670 680 690 700
VYSKATNHFH CIRAGCGFTF TSTSQMTSHK RKHERRHVRS SGALGLPSSL
710 720 730 740 750
LGAKDTEHEE SSNDDLVDFS ALSSKNSSLS ASPTSQQSSA SLAATTATAE
760 770 780 790 800
AMPCASKPPN SKISGLLSQG LPASIPLALA LSNSGLPTAA PYFPILPGRS
810 820 830 840 850
GASLPVGTPG LLGAMSSGAA ATAAADTPAL AASGAGDSAP AAATSVPVPP
860 870 880 890 900
ASIMERISAS KGLISPMMAR LAAAALKPSA TFDPGNGQQA TPTRFPPAPV
910 920 930 940 950
KQEPGENAGA PVPHEVSQDR SLDLTVKEPS NESNGHAVPA NSSLLSSLMN
960 970 980 990 1000
KMSQGNPNLG SLLNIKTEAE GSAAVESSPF LGKAVKALVQ EKLSEPWKVY
1010 1020 1030 1040 1050
LRRFGTKDFC DAQCDFLHKA HFHCVVEECG ALFSTLDGAI KHANFHFRTE
1060 1070 1080 1090 1100
GGAVKGNAEA SFPASAAETK PALAPSSPPA PPVTTATVSS LEGPTPSLAA
1110 1120 1130 1140 1150
VPSTPTLLAW KQLASTIPQL PQIPASVPHL PTSPLATTSL ENAKPQVKPG
1160 1170 1180 1190 1200
FLQFQENDPC LATDCKYANK FHFHCLFGNC KYVCKTSGKA ESHCLDHINP
1210 1220 1230 1240 1250
NNNLVNVRDQ FAYYSLQCLC PNQHCEFRMR GHYHCLRTGC CFVTNITTKL
1260 1270 1280 1290 1300
PWHIKKHEKA ERRAANGFKY FTKREECGRL GCKYNQVNSH FHCIREGCQF
1310 1320 1330 1340 1350
SFLLKHQMTS HARKHMRRML GKNFDRVPPS QGPPSLMDTE TDEYMDYTGC
1360 1370 1380 1390 1400
SPGAVSSESS TMDRSCSSTP VGNESTAAGN TISMPTASGA KKRFWIIEDM
1410 1420 1430 1440 1450
SPFGKRRKTA SSRKMLDEGM MLEGFRRFDL YEDCKDAACQ FSLKVTHYHC
1460 1470 1480 1490 1500
TRENCGYKFC GRTHMYKHAQ HHDRVDNLVL DDFKRFKASL SCHFADCPFS
1510 1520 1530 1540 1550
GTSTHFHCLR CRFRCTDSTK VTAHRKHHGK QDVISAAGFC QFSSSADCAV
1560 1570 1580 1590 1600
PDCKYKLKCS HFHCTYPGCR HTVVGMSQMD SHKRKHEKQE RGEPPGPGVG
1610 1620 1630 1640 1650
AGAGQRRQRR RHCRDRGGNL AELASREAGA LRPTAGPGPA VCSRGLEPGG

GAPRPAA
Length:1,657
Mass (Da):179,948
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65C99D8FCBCEA2F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01004271 Genomic DNA No translation available.
ACTA01012271 Genomic DNA No translation available.
ACTA01020271 Genomic DNA No translation available.
ACTA01188260 Genomic DNA No translation available.
ACTA01196258 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000007485; ENSAMEP00000007180; ENSAMEG00000006796

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01004271 Genomic DNA No translation available.
ACTA01012271 Genomic DNA No translation available.
ACTA01020271 Genomic DNA No translation available.
ACTA01188260 Genomic DNA No translation available.
ACTA01196258 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000007180

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000007485; ENSAMEP00000007180; ENSAMEG00000006796

Phylogenomic databases

eggNOGiKOG4377 Eukaryota
ENOG410XRBA LUCA
GeneTreeiENSGT00390000008187
InParanoidiG1LJS3
OMAiFLHKVHF
TreeFamiTF324787

Family and domain databases

InterProiView protein in InterPro
IPR040373 CASZ1
IPR013087 Znf_C2H2_type
PANTHERiPTHR12451 PTHR12451, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1LJS3_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1LJS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 31, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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