UniProtKB - G1LE11 (G1LE11_AILME)
Protein
Fork-head domain-containing protein
Gene
FOXM1
Organism
Ailuropoda melanoleuca (Giant panda)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 236 – 329 | Fork-headPROSITE-ProRule annotationAdd BLAST | 94 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- protein kinase binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
- G2/M transition of mitotic cell cycle Source: Ensembl
- negative regulation of cell aging Source: Ensembl
- negative regulation of stress-activated MAPK cascade Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of double-strand break repair Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of cell cycle arrest Source: Ensembl
- regulation of Ras protein signal transduction Source: Ensembl
- regulation of reactive oxygen species metabolic process Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Fork-head domain-containing proteinInterPro annotation |
Gene namesi | Name:FOXM1Imported |
Organismi | Ailuropoda melanoleuca (Giant panda)Imported |
Taxonomic identifieri | 9646 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Ursidae › Ailuropoda |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationInteractioni
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9646.ENSAMEP00000005145 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 236 – 329 | Fork-headInterPro annotationAdd BLAST | 94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 108 – 159 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 192 – 232 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 328 – 354 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 463 – 524 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 584 – 660 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 680 – 718 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 200 – 217 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 339 – 353 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 496 – 514 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 606 – 622 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 687 – 702 | PolarSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000158804 |
HOGENOMi | CLU_027498_0_0_1 |
InParanoidi | G1LE11 |
OMAi | EELSHSW |
TreeFami | TF333250 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR042839, FOXM1 IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR46878, PTHR46878, 1 hit |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
G1LE11-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTSPRRPLI LKRRRLPLPV QNAPGETSGE EPKRPPAQQE PGQAQAPKEA
60 70 80 90 100
AEFNSCKFPA GIKIINHPTM PNTQVVAVPN NANIQSIITA LTAKGKESGS
110 120 130 140 150
SGPNKFILIS CGGAPTHPPG PQPQAQTSND PKRTEVVTET PGPKSAARDV
160 170 180 190 200
NLPRPPGALP GQRWESCAGG EAAGCTLDNS LTNIQWLGKM SSDGLGSSSI
210 220 230 240 250
KQEMEEKENR HLEQGQVKVD EPPGASASWQ DSVSERPPYS YMAMIQFAIN
260 270 280 290 300
STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS
310 320 330 340 350
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQSPEHLES KQQQKRPNPE
360 370 380 390 400
LRRNVTIKSE LPLGARRKMK PLLPRVSSYL VPIQFPVNQS LVLQPSVKVP
410 420 430 440 450
LPLAASLMSS ELARHSKRVR IAPKVLLAEE GVAPLPATGP MQEDKVLLGE
460 470 480 490 500
GLSPLLPVQS IKEEEPQPGE ETPPLGRPIK VESPPLEEWP SPCPSVKEES
510 520 530 540 550
SHSWGGSSHS PTPRPKKSYG GLKSPARCVS EMLVIKRREG REMSRSRRKQ
560 570 580 590 600
HLLPPCLDEP ELLFSEGPGT SQRAAELPLL AESSEPASQL GYSQEEGGPF
610 620 630 640 650
KTPIKETLPI SSTPSKSVLP MTPESWRLTP PAKVGGLDFS PVQPPQAAFG
660 670 680 690 700
PLPDSLGLTD FSTTPLKSIR LFDSPRELLN SEPFDLTSDP DPFSTSSPSD
710 720 730 740 750
MEVPKPDSPG PEVASLSANR SLTEGLVLDT MNDSLSKILL DISFPGLEED
760
PLGPDSINWA QFIPELR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ACTA01017261 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSAMET00000005357; ENSAMEP00000005145; ENSAMEG00000004869 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ACTA01017261 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9646.ENSAMEP00000005145 |
Genome annotation databases
Ensembli | ENSAMET00000005357; ENSAMEP00000005145; ENSAMEG00000004869 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000158804 |
HOGENOMi | CLU_027498_0_0_1 |
InParanoidi | G1LE11 |
OMAi | EELSHSW |
TreeFami | TF333250 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR042839, FOXM1 IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR46878, PTHR46878, 1 hit |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1LE11_AILME | |
Accessioni | G1LE11Primary (citable) accession number: G1LE11 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | August 12, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |