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Protein
Submitted name:

Uncharacterized protein

Gene

GABRA2

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GABRA2Imported
OrganismiAiluropoda melanoleuca (Giant panda)Imported
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
Proteomesi
  • UP000008912 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei250 – 274HelicalSequence analysisAdd BLAST25
Transmembranei281 – 300HelicalSequence analysisAdd BLAST20
Transmembranei315 – 337HelicalSequence analysisAdd BLAST23
Transmembranei423 – 441HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500341434329 – 451Sequence analysisAdd BLAST423

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000003629

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 249Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini257 – 340Neur_chan_membInterPro annotationAdd BLAST84

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
InParanoidiG1L9Q6
KOiK05175
OMAiQRWKDER
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005432 GABBAa2_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF218 PTHR18945:SF218, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01615 GABAARALPHA2
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

G1L9Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKLNTYNM QLLFLVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL
60 70 80 90 100
DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE
110 120 130 140 150
RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD
160 170 180 190 200
DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY
210 220 230 240 250
NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI
260 270 280 290 300
GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA
310 320 330 340 350
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV
360 370 380 390 400
NDKKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP
410 420 430 440 450
ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY LNREPVLGVS

P
Length:451
Mass (Da):51,280
Last modified:October 19, 2011 - v1
Checksum:i83552C33F517673A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01042675 Genomic DNA No translation available.
ACTA01050675 Genomic DNA No translation available.
ACTA01058675 Genomic DNA No translation available.
RefSeqiXP_002917061.1, XM_002917015.3

Genome annotation databases

EnsembliENSAMET00000003774; ENSAMEP00000003629; ENSAMEG00000003435
GeneIDi100466319
KEGGiaml:100466319

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01042675 Genomic DNA No translation available.
ACTA01050675 Genomic DNA No translation available.
ACTA01058675 Genomic DNA No translation available.
RefSeqiXP_002917061.1, XM_002917015.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000003629

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000003774; ENSAMEP00000003629; ENSAMEG00000003435
GeneIDi100466319
KEGGiaml:100466319

Organism-specific databases

CTDi2555

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
InParanoidiG1L9Q6
KOiK05175
OMAiQRWKDER
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005432 GABBAa2_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF218 PTHR18945:SF218, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01615 GABAARALPHA2
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG1L9Q6_AILME
AccessioniPrimary (citable) accession number: G1L9Q6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 10, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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