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Entry version 52 (31 Jul 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Collagen type XI alpha 1 chain

Gene

COL11A1

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XI alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL11A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341392536 – 1818Sequence analysisAdd BLAST1783

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000001601

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1589 – 1817Fibrillar collagen NC1InterPro annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni243 – 296DisorderedSequence analysisAdd BLAST54
Regioni356 – 388DisorderedSequence analysisAdd BLAST33
Regioni400 – 520DisorderedSequence analysisAdd BLAST121
Regioni539 – 1558DisorderedSequence analysisAdd BLAST1020

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi277 – 296PolyampholyteSequence analysisAdd BLAST20
Compositional biasi357 – 388PolyampholyteSequence analysisAdd BLAST32
Compositional biasi470 – 496Pro-richSequence analysisAdd BLAST27
Compositional biasi692 – 726Pro-richSequence analysisAdd BLAST35
Compositional biasi784 – 798PolyampholyteSequence analysisAdd BLAST15
Compositional biasi919 – 955Pro-richSequence analysisAdd BLAST37
Compositional biasi1138 – 1152PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1229 – 1243Pro-richSequence analysisAdd BLAST15
Compositional biasi1303 – 1336Pro-richSequence analysisAdd BLAST34
Compositional biasi1354 – 1375Pro-richSequence analysisAdd BLAST22
Compositional biasi1505 – 1521Pro-richSequence analysisAdd BLAST17
Compositional biasi1541 – 1557Pro-richSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG41112X5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1L3Z1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QQARIAM

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 3 hits
PF02210 Laminin_G_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1L3Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERWSSRWKT KRWLWNFTIT TLALTFLFQA REVRGAAPVD VLKALDFHNS
60 70 80 90 100
PEGISETTGF CTNRKNSQGS DTAYRVSKQA QLSAPTKQLF TGGTFPEDFS
110 120 130 140 150
ILFTIKPKKG IQSFLLSIYN EHGIQQVGVE VGRSPVFLFE DHTGKPAPED
160 170 180 190 200
YPLFRTVNIA DGKWHRVAIS VEKKTVTMIV DCKKKTTKPL DRSERAIVDT
210 220 230 240 250
NGITVFGTRI LDEEVFEGDI QQLLIVGDPK AAYDYCEHYS PDCDSSVPKA
260 270 280 290 300
AQAQEPQIDE KKKSNFKKKT RTVATKSKEK SKKFTPPKSE KFASKKKKSY
310 320 330 340 350
QAAAKAKLGV KANIVDDFQE YNYGTEESYQ TEAPRHVSGP NEPNPVEEVF
360 370 380 390 400
TEEYLTGEDY DSQRKNSEDT LNENKGIDGR DSDLLVDGDL GEYDFYEYKE
410 420 430 440 450
YEDKPTSPTN EEFGPGVPAE TDITETSING HGGYGEKGQK GEPAVVEPGM
460 470 480 490 500
LIEGPPGPAG PAGLMGPPGL QGPTGPPGDP GERGPPGRPG LPGADGLPGP
510 520 530 540 550
PGTMLMLPFR YGGDGSKGPT ISAQEAQAQA ILQQARIALR GPPGPMGLTG
560 570 580 590 600
RPGPVGGPGS SGAKGESGDP GPQGPRGVQG PPGPTGKPGK RGRPGADGGR
610 620 630 640 650
GMPGEPGAKG DRGFDGLPGL PGDKGHRGER GPQGPPGPPG EDGMRGEDGE
660 670 680 690 700
IGPRGLPGEA GPRGLLGPRG TPGPTGQPGI AGVDGPPGPK GNMGPQGEPG
710 720 730 740 750
PPGQQGNPGP QGLPGPQGPI GPPGEKGPQG KPGLAGLPGA DGPPGHPGKE
760 770 780 790 800
GQSGEKGALG PPGPQGPIGY PGPRGVKGAD GVRGLKGSKG EKGEDGFPGF
810 820 830 840 850
KGDMGLKGDR GEVGQIGPRG EDGPEGPKGR AGPTGDPGPS GQAGEKGKLG
860 870 880 890 900
VPGLPGYPGR QGPKGSTGFP GFPGANGEKG ARGVAGKPGP RGQRGPTGPR
910 920 930 940 950
GSRGARGPTG KPGPKGTSGG DGPPGPPGER GPQGPQGPVG FPGPKGPPGP
960 970 980 990 1000
PGKDGLPGHP GQRGETGFQG KTGPPGPGGV VGPQGPTGET GPIGERGHPG
1010 1020 1030 1040 1050
PPGPPGEQGL PGAAGKEGAK GDPGPQGISG KDGPAGLRGF PGERGLPGAQ
1060 1070 1080 1090 1100
GAPGLKGGEG PQGPPGPVGS PGERGSAGTA GPIGLPGRPG PQGPPGPAGE
1110 1120 1130 1140 1150
KGAPGEKGPQ GPAGRDGVQG PVGLPGPAGP AGSPGEDGDK GEIGEPGQKG
1160 1170 1180 1190 1200
SKGDKGENGP PGPPGLQGPV GAPGIAGGDG EPGPRGQQGM FGQKGDEGAR
1210 1220 1230 1240 1250
GFPGPPGPIG LQGLPGPPGE KGENGDVGPM GPPGPPGPRG PQGPNGADGP
1260 1270 1280 1290 1300
QGPPGSIGSV GGVGEKGEPG EAGNPGPPGE AGTGGPKGER GEKGEAGPPG
1310 1320 1330 1340 1350
AAGPPGAKGP PGDDGPKGNP GPVGFPGDPG PPGEPGPSGQ DGVGGDKGED
1360 1370 1380 1390 1400
GDPGQPGPPG PSGEAGPPGP PGKRGPPGAA GSEGRQGEKG AKGEAGAEGP
1410 1420 1430 1440 1450
PGKTGPVGPQ GPAGKPGPEG LRGIPGPVGE QGLPGAAGQD GPPGPMGPPG
1460 1470 1480 1490 1500
LPGLKGDPGS KGEKGHPGLI GLIGPPGEQG EKGDRGLPGT QGSPGAKGDG
1510 1520 1530 1540 1550
GIPGPAGPIG PPGPPGLPGP QGPKGTKGSA GPAGQKGDSG LPGPPGPPGP
1560 1570 1580 1590 1600
PGEVIQPLPI LSPKKTRRHA ENMQADAGDN ILDYSDGMEE IFGSLNSLKQ
1610 1620 1630 1640 1650
DIEHMKFPMG TQTNPARTCK DLQLSHPDFP DGEYWIDPNQ GCSGDSFKVY
1660 1670 1680 1690 1700
CNFTSGGETC IYPDKKSEGV RLSSWPKEKP GSWFSEFKRG KLLSYLDVEG
1710 1720 1730 1740 1750
NSINMVQMTF LKLLTASARQ NFTYTCHQSA AWYDESSGSY DKALRFLGSN
1760 1770 1780 1790 1800
DEEMSYDNNP YIKALYDGCA SRKGYEKTVI EINTPKIDQV PIVDVMINDF
1810
GDQNQKFGFE VGPVCFLG
Length:1,818
Mass (Da):182,306
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A29268329E325FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1L3Y6G1L3Y6_AILME
Collagen type XI alpha 1 chain
COL11A1
1,806Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01001031 Genomic DNA No translation available.
ACTA01009031 Genomic DNA No translation available.
ACTA01017031 Genomic DNA No translation available.
ACTA01025031 Genomic DNA No translation available.
ACTA01033031 Genomic DNA No translation available.
ACTA01041030 Genomic DNA No translation available.
ACTA01049030 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000001662; ENSAMEP00000001601; ENSAMEG00000001303

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01001031 Genomic DNA No translation available.
ACTA01009031 Genomic DNA No translation available.
ACTA01017031 Genomic DNA No translation available.
ACTA01025031 Genomic DNA No translation available.
ACTA01033031 Genomic DNA No translation available.
ACTA01041030 Genomic DNA No translation available.
ACTA01049030 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000001601

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000001662; ENSAMEP00000001601; ENSAMEG00000001303

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG41112X5 LUCA
GeneTreeiENSGT00940000154535
InParanoidiG1L3Z1
OMAiQQARIAM
TreeFamiTF323987

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 3 hits
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1L3Z1_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1L3Z1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 31, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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