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UniProtKB - G1L0A3 (G1L0A3_AILME)

Entry version 54 (02 Dec 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

CBFA2/RUNX1 partner transcriptional co-repressor 3

Gene

CBFA2T3

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressorARBA annotation
Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CBFA2/RUNX1 partner transcriptional co-repressor 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CBFA2T3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Ursidae › Ailuropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9646.ENSAMEP00000000305

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 250TAFHInterPro annotationAdd BLAST96
Domaini540 – 576MYND-typeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96DisorderedSequence analysisAdd BLAST96
Regioni117 – 149DisorderedSequence analysisAdd BLAST33
Regioni265 – 327DisorderedSequence analysisAdd BLAST63
Regioni426 – 449DisorderedSequence analysisAdd BLAST24
Regioni583 – 636DisorderedSequence analysisAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili479 – 521Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27PolarSequence analysisAdd BLAST27
Compositional biasi33 – 47PolyampholyteSequence analysisAdd BLAST15
Compositional biasi59 – 73Pro-richSequence analysisAdd BLAST15
Compositional biasi75 – 89PolarSequence analysisAdd BLAST15
Compositional biasi270 – 298PolyampholyteSequence analysisAdd BLAST29
Compositional biasi305 – 319PolarSequence analysisAdd BLAST15
Compositional biasi621 – 636Pro-richSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBFA2T family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTD6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022077_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1L0A3

TreeFam database of animal gene trees

More...TreeFami		TF106303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.1110, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013289, CBFA2T1/2/3
IPR014896, NHR2
IPR037249, TAFH/NHR1_dom_sf
IPR003894, TAFH_NHR1
IPR002893, Znf_MYND

The PANTHER Classification System

More...PANTHERi		PTHR10379, PTHR10379, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08788, NHR2, 1 hit
PF07531, TAFH, 1 hit
PF01753, zf-MYND, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01875, ETOFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00549, TAFH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF158553, SSF158553, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51119, TAFH, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1L0A3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
STSRPMSRAS PLLDSRLPAS TSCSVPRGPR KSGPAAVDRK DKTATMPDSP 
        60         70         80         90        100
TEVKTQPRST PPGMPPPPPA VSQGATRLPS FTPHTNREDG PTMSLPHGRF 
       110        120        130        140        150
HGCLKWSMVC LLMNGSHSPT AVNGAPSTPS GFSNGPATSS TASLSTQHLP 
       160        170        180        190        200
PACGARQLSK LKRFLTTLQQ FGSDISPEIG ERVRTLVLGL VNSTLTIEEF 
       210        220        230        240        250
HSKLQEATNF PLRPFVIPFL KANLPLLQRE LLHCARLAKQ TPAQYLAQHE 
       260        270        280        290        300
QLLLDASASS PIDSSELLLE VNENGKRRTP DRTKENGSDR DPLHPDHLSK 
       310        320        330        340        350
RPCTLSPAQR YSPSNGLPHA TQPPHYRLED MAMAHHFRDS YRHPDPRELR 
       360        370        380        390        400
ERHRQLAVHG SRQEEVIDHR LTEREWAEEW KHLNNLLNCI TDMAEKTRRS 
       410        420        430        440        450
LTVLRQCQEA DREELNHWIR RYSDTEDAKK GPMPATARPL NSSTGTEGSQ 
       460        470        480        490        500
LDAHREFMPR TLSGYMPEEI WRKAEEAVNE VKRQAMSELQ KAVSDAERKA 
       510        520        530        540        550
HELISTERAK MERALAEARR QASEDALTVV NQQEDSSESC WNCGRKASET 
       560        570        580        590        600
CSGCNAARYC GSFCQHRDWE KHHXXXXXXX XXPAAAVADP GPAQPDTAAS 
       610        620        630 
LGPCLPTGXX TLGVACGASP GPAPSPAPPG KAERAP
Length:636
Mass (Da):70,000
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54D6857D794C5B6F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1L0A6G1L0A6_AILME
CBFA2/RUNX1 partner transcriptional...
CBFA2T3
596Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
ACTA01100423 Genomic DNA No translation available.
ACTA01108423 Genomic DNA No translation available.
ACTA01116423 Genomic DNA No translation available.
ACTA01124423 Genomic DNA No translation available.
ACTA01132423 Genomic DNA No translation available.
ACTA01140423 Genomic DNA No translation available.
ACTA01148422 Genomic DNA No translation available.
ACTA01156421 Genomic DNA No translation available.
ACTA01164420 Genomic DNA No translation available.
ACTA01172418 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSAMET00000000315; ENSAMEP00000000305; ENSAMEG00000000272

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01100423 Genomic DNA No translation available.
ACTA01108423 Genomic DNA No translation available.
ACTA01116423 Genomic DNA No translation available.
ACTA01124423 Genomic DNA No translation available.
ACTA01132423 Genomic DNA No translation available.
ACTA01140423 Genomic DNA No translation available.
ACTA01148422 Genomic DNA No translation available.
ACTA01156421 Genomic DNA No translation available.
ACTA01164420 Genomic DNA No translation available.
ACTA01172418 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000000305

Genome annotation databases

EnsembliENSAMET00000000315; ENSAMEP00000000305; ENSAMEG00000000272

Phylogenomic databases

eggNOGiENOG502QTD6, Eukaryota
GeneTreeiENSGT00950000183176
HOGENOMiCLU_022077_2_0_1
InParanoidiG1L0A3
TreeFamiTF106303

Family and domain databases

Gene3Di1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR013289, CBFA2T1/2/3
IPR014896, NHR2
IPR037249, TAFH/NHR1_dom_sf
IPR003894, TAFH_NHR1
IPR002893, Znf_MYND
PANTHERiPTHR10379, PTHR10379, 1 hit
PfamiView protein in Pfam
PF08788, NHR2, 1 hit
PF07531, TAFH, 1 hit
PF01753, zf-MYND, 1 hit
PRINTSiPR01875, ETOFAMILY
SMARTiView protein in SMART
SM00549, TAFH, 1 hit
SUPFAMiSSF158553, SSF158553, 1 hit
PROSITEiView protein in PROSITE
PS51119, TAFH, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1L0A3_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1L0A3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: December 2, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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