UniProtKB - G1KXT7 (G1KXT7_ANOCA)
Protein
Procollagen-proline 4-dioxygenase
Gene
P4HA2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.ARBA annotation
Catalytic activityi
- 2-oxoglutarate + L-prolyl-[procollagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[procollagen]ARBA annotationEC:1.14.11.2ARBA annotation
Cofactori
L-ascorbateARBA annotation
GO - Molecular functioni
- iron ion binding Source: InterPro
- L-ascorbic acid binding Source: InterPro
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: InterPro
- procollagen-proline 4-dioxygenase activity Source: UniProtKB-EC
GO - Biological processi
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: GO_Central
Keywordsi
Molecular function | DioxygenaseARBA annotation, Oxidoreductase |
Ligand | IronARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:P4HA2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen ARBA annotation
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003413750 | 22 – 557 | Procollagen-proline 4-dioxygenaseSequence analysisAdd BLAST | 536 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000012415, Expressed in heart and 11 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 207 – 240 | TPR_REGIONInterPro annotationAdd BLAST | 34 | |
Repeati | 207 – 240 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 414 – 542 | Fe2OG dioxygenaseInterPro annotationAdd BLAST | 129 |
Sequence similaritiesi
Belongs to the P4HA family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1591, Eukaryota |
GeneTreei | ENSGT00940000157695 |
HOGENOMi | CLU_024155_1_0_1 |
InParanoidi | G1KXT7 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR013547, Pro_4_hyd_alph_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13640, 2OG-FeII_Oxy_3, 1 hit PF08336, P4Ha_N, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KXT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPWIKQLLF TCLLCIGQTQ AEFFTSIGQM TDLIYAEKDL VQSLKAYIQE
60 70 80 90 100
EESKLIKIKS WAEKMESLTT KSTSDPEGYL SHPVNAYKLV KRLNTEWLEL
110 120 130 140 150
ENLVLEDATK GFIANLTVQR QFFPNEEDET GAAKALMRLQ DTYKLDPETI
160 170 180 190 200
SKGEFPGTKY RSLLTVDDCF GMGKTAYNDG DYYHTVLWME QALKQHDRGE
210 220 230 240 250
EATITKATIL DYLSYAIFQL GDIHRAMELT RRLISLDPSH ERAGSNMQYF
260 270 280 290 300
EKLLENEQNE KALDDAPNAT EPSTYNGIYE RPPDYLPERE IYEALCRGEG
310 320 330 340 350
VKMTPRRQKR LFCRYHNGNQ NPHLLIAPFK EEDEWDSPHI VRYYNVLSDE
360 370 380 390 400
EIEKIKELAK PKLARATVRD PKTGVLTVAN YRVSKSSWLE EEDDLVVAKV
410 420 430 440 450
NQRMEHITGL TVKTAELLQV ANYGMGGQYE PHFDFSRRPF DSTLKTEGNR
460 470 480 490 500
LATFLNYKEE PDAFKRLGTG NRVATFLNYM SDVEAGGATV FPDFGAAIWP
510 520 530 540 550
KKGTAVFWYN LFRSGEGDYR TRHAACPVLV GCKWVSNKWF HERGNEFLRP
CGTTEVD
Genome annotation databases
Ensembli | ENSACAT00000024664; ENSACAP00000020359; ENSACAG00000012415 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000020359 |
Genome annotation databases
Ensembli | ENSACAT00000024664; ENSACAP00000020359; ENSACAG00000012415 |
Phylogenomic databases
eggNOGi | KOG1591, Eukaryota |
GeneTreei | ENSGT00940000157695 |
HOGENOMi | CLU_024155_1_0_1 |
InParanoidi | G1KXT7 |
Gene expression databases
Bgeei | ENSACAG00000012415, Expressed in heart and 11 other tissues |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR005123, Oxoglu/Fe-dep_dioxygenase IPR006620, Pro_4_hyd_alph IPR013547, Pro_4_hyd_alph_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13640, 2OG-FeII_Oxy_3, 1 hit PF08336, P4Ha_N, 1 hit |
SMARTi | View protein in SMART SM00702, P4Hc, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KXT7_ANOCA | |
Accessioni | G1KXT7Primary (citable) accession number: G1KXT7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |