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Entry version 58 (02 Jun 2021)
Sequence version 1 (19 Oct 2011)
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Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

CTDP1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This promotes the activity of RNA polymerase II.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTDP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000001148, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000018624

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 327FCP1 homologyInterPro annotationAdd BLAST167
Domaini622 – 721BRCTInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni314 – 370DisorderedSequence analysisAdd BLAST57
Regioni402 – 579DisorderedSequence analysisAdd BLAST178
Regioni753 – 792DisorderedSequence analysisAdd BLAST40
Regioni808 – 836DisorderedSequence analysisAdd BLAST29
Regioni856 – 958DisorderedSequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi322 – 350Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi351 – 370Polar residuesSequence analysisAdd BLAST20
Compositional biasi412 – 429Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi430 – 467Polar residuesSequence analysisAdd BLAST38
Compositional biasi468 – 504Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi774 – 788Polar residuesSequence analysisAdd BLAST15
Compositional biasi863 – 892Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi893 – 908Polar residuesSequence analysisAdd BLAST16
Compositional biasi909 – 936Basic and acidic residuesSequence analysisAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0323, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007683_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KVK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYAHMIA

TreeFam database of animal gene trees

More...
TreeFami
TF315104

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR039189, Fcp1
IPR015388, FCP1_C
IPR004274, FCP1_dom
IPR011947, FCP1_euk
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR011053, Single_hybrid_motif

The PANTHER Classification System

More...
PANTHERi
PTHR23081, PTHR23081, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09309, FCP1_C, 1 hit
PF03031, NIF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 1 hit
SM00577, CPDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230, SSF51230, 1 hit
SSF52113, SSF52113, 1 hit
SSF56784, SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02250, FCP1_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 1 hit
PS50969, FCP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KVK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEEDSGAAA AAAAPSEVTE IRVSGPQPLR LLEWKVSAGA AVKIGSVLAV
60 70 80 90 100
CAPISASEAR GPERKVKAEL PGVVRELCVR LGQVIPPGGV LVRLEACSHP
110 120 130 140 150
VVMKGLCAEC GQDLTQLRSK NGKQNMPVST ATVSMVHSVP ELMVSSEQAE
160 170 180 190 200
QLGREDQERL RRNRKLVLMV DLDQTLIHTT EQHCQQMSNR GIFHYQLGRG
210 220 230 240 250
EPMLHTRLRP HCKEFLEKIA KLYELHVFTF GSRLYAHTIA AFLDSEKKLF
260 270 280 290 300
SHRILSRDEC IDPFSKTGNL RNLFPCGDSM VCIIDDREDV WKFAPNLITV
310 320 330 340 350
KKYVYFQGTG DINAPPGSKE AQMRKKANHS SKLNETSDAV TKDSEEVKNA
360 370 380 390 400
TNIEEQSNGV RKTTKEINGN NSVSSEALSW DLNSGDKVKD CLSDPDHIAD
410 420 430 440 450
VTSANDDQMN AKESHVSSDQ DKRTVTEKQQ TADKTANCLD FELSTDSDSD
460 470 480 490 500
SGLDARKSSS SSASDSENEG KRSWRKSKQS LQEERKVPLL ETETNVEKDG
510 520 530 540 550
LENHSGDTLS STSNNPHPKP FDLEAHEESE QDSLCSLGNG CVDKKEAETE
560 570 580 590 600
SQNSEQSGIT VGESLDQSME EEEDDDTDQD DHLIYLEEIL VRVHADYYSK
610 620 630 640 650
YDKYVRKETD EIPDIRKIVP ELKRKVLAGV TILFSGLYPT NFAIERTREN
660 670 680 690 700
YHATALGAKI AKTLILDEND PNKTTHLIAA RAGTEKVRQG QTCKSLHIVN
710 720 730 740 750
PDWLWSCLER WDKVEEQLFP LKDDYLKTQR ENSPAMFPDI HSAFQTALFH
760 770 780 790 800
PTPIHPKCQP SPEVRLYDPN TGKLIRKGSQ NSTPSPPLNL PVHGEHSLFR
810 820 830 840 850
IVQPHQQLFD EDGMPSSENE EPGPSKRKRQ PSMSETMPLY TLCKEDLESM
860 870 880 890 900
DKEVDDILGE GSDDSDSEKK KGRGRKEKAP QNNKKDPINI KTEERPVSTS
910 920 930 940 950
SSERSFTGSI PRGHKRKLVE DDVASESSKG SSNEDEEGSS SEADEMAAAL

EAELNDFM
Length:958
Mass (Da):106,699
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EBDBFA4319FCA8F
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000022260; ENSACAP00000018624; ENSACAG00000001148

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000018624

Genome annotation databases

EnsembliENSACAT00000022260; ENSACAP00000018624; ENSACAG00000001148

Phylogenomic databases

eggNOGiKOG0323, Eukaryota
GeneTreeiENSGT00390000015641
HOGENOMiCLU_007683_1_2_1
InParanoidiG1KVK5
OMAiNYAHMIA
TreeFamiTF315104

Gene expression databases

BgeeiENSACAG00000001148, Expressed in forelimb bud and 14 other tissues

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR039189, Fcp1
IPR015388, FCP1_C
IPR004274, FCP1_dom
IPR011947, FCP1_euk
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR011053, Single_hybrid_motif
PANTHERiPTHR23081, PTHR23081, 2 hits
PfamiView protein in Pfam
PF09309, FCP1_C, 1 hit
PF03031, NIF, 1 hit
SMARTiView protein in SMART
SM00292, BRCT, 1 hit
SM00577, CPDc, 1 hit
SUPFAMiSSF51230, SSF51230, 1 hit
SSF52113, SSF52113, 1 hit
SSF56784, SSF56784, 1 hit
TIGRFAMsiTIGR02250, FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS50969, FCP1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KVK5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KVK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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