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Entry version 58 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Pleckstrin homology and RhoGEF domain containing G3

Gene

PLEKHG3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pleckstrin homology and RhoGEF domain containing G3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHG3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000009366, Expressed in female gonad and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000018579

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 231DHInterPro annotationAdd BLAST181
Domaini255 – 353PHInterPro annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni390 – 421DisorderedSequence analysisAdd BLAST32
Regioni460 – 657DisorderedSequence analysisAdd BLAST198
Regioni683 – 723DisorderedSequence analysisAdd BLAST41
Regioni737 – 766DisorderedSequence analysisAdd BLAST30
Regioni811 – 844DisorderedSequence analysisAdd BLAST34
Regioni856 – 876DisorderedSequence analysisAdd BLAST21
Regioni1020 – 1039DisorderedSequence analysisAdd BLAST20
Regioni1073 – 1098DisorderedSequence analysisAdd BLAST26
Regioni1119 – 1168DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 421PolarSequence analysisAdd BLAST29
Compositional biasi511 – 530AcidicSequence analysisAdd BLAST20
Compositional biasi547 – 570PolarSequence analysisAdd BLAST24
Compositional biasi583 – 598PolyampholyteSequence analysisAdd BLAST16
Compositional biasi827 – 844PolarSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3518, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007600_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KVI5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEIVKMW

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13243, PH_PLEKHG1_G2_G3, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043324, PH_PLEKHG1_G2_G3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KVI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDWSDLAQT PVDAASLRTG LLHNANNNAS MGPWRTLKSP SLSSSASKLS
60 70 80 90 100
YLERVVLEIV ESERMYVRDL RSIVENYLGK IIDMQELLLR PEQVSALFGN
110 120 130 140 150
IEDIYELNSE LLQDLDSCHN DPVAVARCFV DRSQDFDIYT QYCNNYPNSV
160 170 180 190 200
AALTDCMRNK QLAKFFRERQ EQIRHSLPLG SYLLKPVQRI LKYHLLLQEI
210 220 230 240 250
AKHFDIEEDG YEVVEEAIDT MTCVAWYIND MKRKHEHAVR LQEIQSLLIN
260 270 280 290 300
WKGPDLTTYG ELVLEGTFRV HRVKNERTFF LFDKMLLITK KRGDHYIYKS
310 320 330 340 350
HIPCSSLMLI ESTRDSLCFT VTHYKHRKQQ YNIQAKSGEE KRVWTHHIKR
360 370 380 390 400
LILENHHAII PQKAKQAILE MDSYYPARYK YSPERLKKSW SCQPTEDIPQ
410 420 430 440 450
QARQGRRQSE PFHGKNSSQK FLEGFHSFAM TRLKSRRRSE PTKQILKQLS
460 470 480 490 500
SKVLGQLSCG MGQKHADSDG ALLEFGEPPQ PPNSQEEEEA NLQALPQEFP
510 520 530 540 550
EELAESDGSE KETGPEEEEE EEEEEEEEEA ALAVQGKQHK AHEGPKQCQS
560 570 580 590 600
PASSEKNRVM ETSSSMPKVP QARSAMELNR MLEISSCKDE HPEESNLDPE
610 620 630 640 650
AGALDSLLAG QHENQDQGLD GLEPMDNVEE LKPLSSEEEE EEEEDDRPAQ
660 670 680 690 700
PKSILPFSVL DQASIIAERF ASSLSRRSSL ALEEGKGYLT PTQASRSNSV
710 720 730 740 750
LSLEEGEKAP CRHNSSSTAA IDSQGCLPMQ EASVELSNSC SGRASPGLTE
760 770 780 790 800
PDRASSCRRK ESMLSQQDRQ LLDKIKNYYV YAEHQDAGFS VRRRESLSYI
810 820 830 840 850
PKGVVRNSVF RINSLPQPES DQETLKRKQP GPSSSSNGTG RTAAWVLSNR
860 870 880 890 900
PAVGPQALRS ERSCDERPAP ITEAEFKPST EMIKVWEEME KQKREDHWNR
910 920 930 940 950
RLRRQENGLD LHEPLFILED EDLGAITEES AVPSPESKSP VEHAPPSKLP
960 970 980 990 1000
WKLMQELGGF EQDQGLARLH PRIMQLAHLT EAELAEKVKN KVYQLARQYS
1010 1020 1030 1040 1050
LRIKGHKPTA HRRLAEVEEE MKGNALAGQR DTDKKAKGKR KPDLILLNYE
1060 1070 1080 1090 1100
QVVLQEASPL TLLCSSASSH EKSPKRFSYS PCSSSPHLTS PTSTLSRSPL
1110 1120 1130 1140 1150
SPIVAEKFNW PDVRELRSKY SPQAGVEKNR PPPVNRSRSA PEKMMDTGRV
1160 1170 1180 1190 1200
QRNHQCSKKN VKAGVKSPRG EIQSYRVEPS HCFIPKYQAC DAQKELCVTA
1210 1220 1230 1240 1250
ETSLENSQRV IVMEKLPDMT VEPDESYVQI RSPTSREKIS LKAVVERCKA
1260 1270 1280 1290 1300
YQESEEYRRR EEDAQEVAPR KALPQVWWDK TDSSQHSLVK NLREKFQTLN

SNS
Length:1,303
Mass (Da):148,360
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9819ADEA4CE2673
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000026649; ENSACAP00000018579; ENSACAG00000009366

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000018579

Genome annotation databases

EnsembliENSACAT00000026649; ENSACAP00000018579; ENSACAG00000009366

Phylogenomic databases

eggNOGiKOG3518, Eukaryota
GeneTreeiENSGT00940000156521
HOGENOMiCLU_007600_0_0_1
InParanoidiG1KVI5
OMAiSEIVKMW

Gene expression databases

BgeeiENSACAG00000009366, Expressed in female gonad and 13 other tissues

Family and domain databases

CDDicd13243, PH_PLEKHG1_G2_G3, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043324, PH_PLEKHG1_G2_G3
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KVI5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KVI5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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