STAT3

Functionⁱ

GO - Molecular functionⁱ

chromatin DNA binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
nuclear receptor activity Source: Ensembl
primary miRNA binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II repressing transcription factor binding Source: Ensembl

GO - Biological processⁱ

Keywordsⁱ

Molecular function	ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal transducer and activator of transcriptionUniRule annotation
Gene namesⁱ	Name:STAT3Imported
Organismⁱ	Anolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifierⁱ	28377 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
Proteomesⁱ	UP000001646 Componentⁱ: Chromosome 6

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation

PTM / Processingⁱ

Keywords - PTMⁱ

PhosphoproteinUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSACAG00000017940, Expressed in lung and 15 other tissues

Bgeeⁱ

ENSACAG00000017940, Expressed in lung and 15 other tissues

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
RNA polymerase II repressing transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	28377.ENSACAP00000017673

STRINGⁱ

28377.ENSACAP00000017673

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	580 – 670	SH2InterPro annotationAdd BLAST		91

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	141 – 168	Sequence analysisAdd BLAST		28
Coiled coilⁱ	270 – 290	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the transcription factor STAT family.UniRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00990000203570
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	G1KUK6
Database of Orthologous Groups More...OrthoDBⁱ	327469at2759
TreeFamⁱ	TF318648

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G1KUK6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EENRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKTLVDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPLLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGEVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGINYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEATDP 
       710        720        730        740        750
GTGTAPYLKT KFICVTPTTC SSTIELPMSP RTLESLIPFC SNGEGAEGNA 
       760        770 
SGQFESLQVF DMEMAGDCAN SPM

Length:773

Mass (Da):88,333

Last modified:June 26, 2013 - v2

Checksum:ⁱEB4437CC8DBCCCA1

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_008111615.1, XM_008113408.2

RefSeqⁱ

XP_008111615.1, XM_008113408.2

Genome annotation databases

Ensemblⁱ	ENSACAT00000018021; ENSACAP00000017673; ENSACAG00000017940
GeneIDⁱ	100566559

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G1KUK6	Signal transducer and activator of transcription		Paroedura picta		828	UniRef90_G1KUK6
Signal transducer and activator of transcription		CALUR		769
Signal transducer and activator of transcription		ZALCA		769
Signal transducer and activator of transcription		ODORO		769
signal transducer and activator of transcription 3 isoform X2		SHEEP		769
+109

Protein	Similar proteins		Species	Score	Length	Source
G1KUK6	Signal transducer and activator of transcription 3	)	HUMAN		770	UniRef50_P40763
Signal transducer and activator of transcription 3		CHICK		771
Signal transducer and activator of transcription 3		PIG		770
Signal transducer and activator of transcription 3		BOVIN		770
Signal transducer and activator of transcription 3		RAT		770
+1168

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_008111615.1, XM_008113408.2

RefSeqⁱ

XP_008111615.1, XM_008113408.2

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	28377.ENSACAP00000017673

STRINGⁱ

28377.ENSACAP00000017673

Genome annotation databases

Ensemblⁱ	ENSACAT00000018021; ENSACAP00000017673; ENSACAG00000017940
GeneIDⁱ	100566559

Organism-specific databases

CTDⁱ	6774

CTDⁱ

6774

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
GeneTreeⁱ	ENSGT00990000203570
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	G1KUK6
OrthoDBⁱ	327469at2759
TreeFamⁱ	TF318648

Gene expression databases

Bgeeⁱ	ENSACAG00000017940, Expressed in lung and 15 other tissues

Bgeeⁱ

ENSACAG00000017940, Expressed in lung and 15 other tissues

Family and domain databases

CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G1KUK6_ANOCA
Accessionⁱ	G1KUK6Primary (citable) accession number: G1KUK6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 19, 2011
	Last sequence update:	June 26, 2013
	Last modified:	December 2, 2020
	This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G1KUK6 (G1KUK6_ANOCA)

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Signal transducer and activator of transcription

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ