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Protein
Submitted name:

Estrogen receptor 2

Gene

ESR2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi174 – 249Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor 2Imported
Gene namesi
Name:ESR2Imported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSACAG00000015814

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000015597

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 249Nuclear receptorInterPro annotationAdd BLAST76
Domaini292 – 526NR LBDInterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
InParanoidiG1KRR5
KOiK08551
OrthoDBiEOG091G03V4
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028355 ER-beta/gamma
IPR021064 Estrogen_rcpt_beta_N
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12497 ERbeta_N, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500102 ER-b, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

G1KRR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCASSHKE CSHLLPSLQD HGCSKTEVKS SLSELGSPAI PFSCSPSALT
60 70 80 90 100
VEHSPIYIPS SYMENRHDYS AMAFYTPAAM MNYNIPGNFS DSESTALRQT
110 120 130 140 150
ASPSMLWSGP GHISPLTLHC QSSVLYAEQP KSPWCEARPM DHVLPMHREV
160 170 180 190 200
LKRKASGSDC TSPTTNSPSS KRDAHFCAVC SDYASGYHYG VWSCEGCKAF
210 220 230 240 250
FKRSIQGHND YICPATNQCT IDKNRRKSCQ ACRLRKCYEV GMMKCGSRRE
260 270 280 290 300
RCGYRIIRRH RNSEDSLHCV SKVKKTNETI IQMKEVLVNT LTPEQFVSIL
310 320 330 340 350
LEAEPPNVLV SRPNKPFTEA SMMMSLTKLA DKELVHMIGW AKKIPGFIEL
360 370 380 390 400
SLYDQVRLLE SCWLEVLMVG LMWRSIDHPG KLIFAPDLVL DRDEGKCVEG
410 420 430 440 450
ILEIFDMLLA TTSRLRELKL QHKEYLCVKA MILLNSSMFP LPSTTEEPES
460 470 480 490 500
HRKLNHLLNS VTDALVWVIA KSGIPLPQQT TRLANLLMLL SHVRHASNKG
510 520 530 540 550
MEHLLSMKCK NVVPVYDLLL EMLNAHTVRN HRKTPISNLE ISPSEQTETT

DGMQL
Length:555
Mass (Da):62,459
Last modified:June 26, 2013 - v2
Checksum:i40D8107BAC8C96F3
GO

Sequence databases

RefSeqiXP_016846689.1, XM_016991200.1

Genome annotation databases

EnsembliENSACAT00000015911; ENSACAP00000015597; ENSACAG00000015814
GeneIDi100554143
KEGGiacs:100554143

Similar proteinsi

Entry informationi

Entry nameiG1KRR5_ANOCA
AccessioniPrimary (citable) accession number: G1KRR5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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