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Entry version 52 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC100563069

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100563069Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi339 ↔ 348PROSITE-ProRule annotation
Disulfide bondi404 ↔ 413PROSITE-ProRule annotation
Disulfide bondi467 ↔ 476PROSITE-ProRule annotation
Disulfide bondi520 ↔ 529PROSITE-ProRule annotation
Disulfide bondi532 ↔ 546PROSITE-ProRule annotation
Disulfide bondi549 ↔ 561PROSITE-ProRule annotation
Disulfide bondi551 ↔ 568PROSITE-ProRule annotation
Disulfide bondi570 ↔ 579PROSITE-ProRule annotation
Disulfide bondi863 ↔ 875PROSITE-ProRule annotation
Disulfide bondi865 ↔ 882PROSITE-ProRule annotation
Disulfide bondi884 ↔ 893PROSITE-ProRule annotation
Disulfide bondi911 ↔ 923PROSITE-ProRule annotation
Disulfide bondi913 ↔ 930PROSITE-ProRule annotation
Disulfide bondi932 ↔ 941PROSITE-ProRule annotation
Disulfide bondi976 ↔ 985PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi1090 ↔ 1099PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1155PROSITE-ProRule annotation
Disulfide bondi1174 ↔ 1186PROSITE-ProRule annotation
Disulfide bondi1176 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1195 ↔ 1204PROSITE-ProRule annotation
Disulfide bondi1222 ↔ 1234PROSITE-ProRule annotation
Disulfide bondi1224 ↔ 1241PROSITE-ProRule annotation
Disulfide bondi1243 ↔ 1252PROSITE-ProRule annotation
Disulfide bondi1255 ↔ 1269PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000014991, Expressed in embryo and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000014707

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 309Laminin N-terminalInterPro annotationAdd BLAST236
Domaini310 – 373Laminin EGF-likeInterPro annotationAdd BLAST64
Domaini374 – 436Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini437 – 496Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini497 – 548Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini549 – 590Laminin EGF-likeInterPro annotationAdd BLAST42
Domaini588 – 857Laminin IV type BInterPro annotationAdd BLAST270
Domaini863 – 910Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini911 – 956Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini957 – 1006Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1007 – 1065Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini1066 – 1117Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1118 – 1173Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini1174 – 1221Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1222 – 1271Laminin EGF-likeInterPro annotationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1378 – 1398Sequence analysisAdd BLAST21
Coiled coili1548 – 1568Sequence analysisAdd BLAST21
Coiled coili1648 – 1734Sequence analysisAdd BLAST87
Coiled coili1756 – 1790Sequence analysisAdd BLAST35
Coiled coili1799 – 1850Sequence analysisAdd BLAST52

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001560_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KQI2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTGACPC

TreeFam database of animal gene trees

More...
TreeFami
TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR033112, PLipase_A2_Asp_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit
PS00119, PA2_ASP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KQI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRSHTLSLR NPTCLMSQLE EGNEAAPDKT RGASTWMLKT LTLPMPLLLY
60 70 80 90 100
LLLWVQVADA QGPEEPDLLY HGCLEGSCYP ATGNLLIGRA QSLSATSTCG
110 120 130 140 150
LEGPQDYCIV SHLQDSEKCF LCDSHSASLR ENHHIENVIY LSGQDGEQTW
160 170 180 190 200
WQSENGVEEV SIRLDLEAEF HFTHLIMKFK TFRPAAMLIE RSSDFGRSWK
210 220 230 240 250
VYRYFAFNCS KLFPGIPTQI PAHVNQAVCD QRYSEIEPSS HGEVIFKVLD
260 270 280 290 300
PAIKVEDPYS QEIQDLLRVT NLRVNFTKLH TLGDNLLDSR LQVLQKYYYA
310 320 330 340 350
VYELVLRGSC FCYGHASECA PLAGVTNLVE GMIHGRCVCK HHTKGLNCEL
360 370 380 390 400
CKDFYQELPW RPAEAHDSHA CKECNCNEHS HRCHFDMAVY LATGNTSGGV
410 420 430 440 450
CDECLHNTMG RHCQLCKPFY YRNPMADIRA STACIPCDCD PVGSLDGGVC
460 470 480 490 500
DSHTDVSLGM IAGQCRCKDN VKGVRCDSCK EAFYGLSQND PLGCQPCRCD
510 520 530 540 550
PRGIIAGNSP CDHISGDCYC KRFVTGRYCN QCLPEYWGLS YDMTGCRGCA
560 570 580 590 600
CDFGGAYSNR CSMDDGQCPC RPHFMGRQCD DVQPGFFCMP LDYYMYEAEH
610 620 630 640 650
ATGLPPTHQS LPGALRPEAP VDCVEYYNGV QNGRKVRLRR QHSTIRVLQQ
660 670 680 690 700
RGALRRARQL QQKPDVEVIQ REHTGHMITW TGPGFARVRD GAGLSFHISN
710 720 730 740 750
IPYPMDYDIL LRYEPESTED WEAVVSVSSQ ALPMSPRCGN VLPSEQMYRE
760 770 780 790 800
SLPHSSRYVL LPRPFCFEPR NHYEITVRFQ RTGVAQRHPA AFLLVDSLVL
810 820 830 840 850
LPRVTELPGL HGNDPASVER REALERYTCL EAFRMATMPD LAETCAQLLC
860 870 880 890 900
SISALMHDGA LPCQCDPQGS TSSVCHKLGG QCQCKPNVIG RRCDECVPGT
910 920 930 940 950
YGFGPYGCIP CACSHEGSAS KICEPTSGQC RCQHGTVGRQ CDQCPPGHWG
960 970 980 990 1000
FPSCRPCHCN GHSEECDLHT GACHDCRDYT AGRHCERCLD GYYGDPILGS
1010 1020 1030 1040 1050
GQQCRPCPCP GYPGSRHYHG ISCDTDRETN QISCLCAPGY TGLRCDRCSP
1060 1070 1080 1090 1100
GYFGAPEQEG GACRPCQCNN NIDTSDPEAC DPHTGQCLRC LYYTSGPHCA
1110 1120 1130 1140 1150
ECQPGYYGSA FQRSCRRCTC NEQGTLPMHC SKGICHCDRT TGNCPCRANV
1160 1170 1180 1190 1200
VDKNCDRCAQ NFWGFGSDLG CQPCDCDPAH SLRSDCNMFT GQCHCQPGFG
1210 1220 1230 1240 1250
GRVCSQCQED HWGDPEQECL PCECDPAGSE SPQCDRLSGH CLCREGFTGR
1260 1270 1280 1290 1300
RCHQCQRGFH KNFPRCSPCH PCFGQWDKVL GQLWEQVQRL QDAVKALKEG
1310 1320 1330 1340 1350
GPIPEASSNR MRNLENSLDH VEQLLGDGSS PNAPLLHEIS TVLADIRADM
1360 1370 1380 1390 1400
DELWQQLQTT NSHLDETDQT DTGQRSHLNK LNRELRELNH TVNHLRKMSN
1410 1420 1430 1440 1450
GSFNESFHSI LESFQQSELA QQRANASVQG PQSPVGQAKH TRRVTVELLR
1460 1470 1480 1490 1500
RRGDAFRQSA AVHRKSLQNI QEQIDSLGLS TINEKICGAS GEEECEPCGG
1510 1520 1530 1540 1550
ASCRDSLGQR HCGGPGCTGA LPVSAKALDT AQNISLQLET TLKQLGTISS
1560 1570 1580 1590 1600
KVQEIQELAQ DARNHAQETL GQAQGARSRV EKSTAKLREF IQKIKDFLAE
1610 1620 1630 1640 1650
EGADPESIEL VAQQVLNISL PGSPGQISSL IKEIHDRIGE LDGVDIILNN
1660 1670 1680 1690 1700
TVHNLTRARE LLAEAEEAKE RAEGVEAIIA ETRAELSGVR EQVSAAERAM
1710 1720 1730 1740 1750
KSAKEAIRSV EGRIRQAERQ LQTLVSKESQ VESRLGDLAQ DVADLQKKSQ
1760 1770 1780 1790 1800
ANQQLAQEAK GKAEHATAAA GRLENDVEKV MQGYQKLQDK LGELPQDVLF
1810 1820 1830 1840 1850
KLKNLRDEAQ NLLNKANDSK RKLEELEERF QTNEKEMKDK ANTLQSLEKQ
1860
VTDLLEFIRN KATAYATC
Length:1,868
Mass (Da):207,462
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7831643BD251C80
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000015008; ENSACAP00000014707; ENSACAG00000014991

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000014707

Genome annotation databases

EnsembliENSACAT00000015008; ENSACAP00000014707; ENSACAG00000014991

Phylogenomic databases

eggNOGiKOG0994, Eukaryota
GeneTreeiENSGT00940000156060
HOGENOMiCLU_001560_1_0_1
InParanoidiG1KQI2
OMAiQTGACPC
TreeFamiTF312903

Gene expression databases

BgeeiENSACAG00000014991, Expressed in embryo and 7 other tissues

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR033112, PLipase_A2_Asp_AS
PfamiView protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit
PS00119, PA2_ASP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KQI2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KQI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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