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Entry version 48 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein

AKAP_110 domain-containing protein

Gene

SPHKAP

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase A binding Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AKAP_110 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPHKAPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000014852, Expressed in brain and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000014593

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1588 – 1676AKAP_110InterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni274 – 295DisorderedSequence analysisAdd BLAST22
Regioni800 – 831DisorderedSequence analysisAdd BLAST32
Regioni1451 – 1474DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi274 – 288PolarSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ6Q, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_243215_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KQD8

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVGHFME

Database of Orthologous Groups

More...
OrthoDBi
33853at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105426

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018292, AKAP_110_C
IPR008382, SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226, PTHR10226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05716, AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KQD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPPTLQVP PSNFQSPLMY EASEHQSVGT DSSGSSLGSS VTACKKVLCS
60 70 80 90 100
NSLLESTDYW LQNQKTPCRI GIVEDKLEKN YTSVCFVNLD AHKDDCDNEL
110 120 130 140 150
MKQKLVDISP NLPKLISSMN VQPPKENEII LLSGLTSGNL QSDFEETQCS
160 170 180 190 200
WLADVCLVQC ARGNRKNSTS CIIFEINKFL IGLELVREKQ LHIEAGILKP
210 220 230 240 250
EDDTNCSVSS IEEDFLTASE HFEDENEPGE YENGQDHLSI TETVIESKTY
260 270 280 290 300
RGKEFEHLHC HKSTLEANCI NKDSHTTSAR TSSSSEEECN GEGEIDISKT
310 320 330 340 350
VDKAIEQLHW KVDQPGKSKP SSNTDCLDDF SDLSEDVTLT IMAKEEGISL
360 370 380 390 400
DDATVSQNTN SDTPDCRTDR TPHLFIKNEQ ATAGQFATNL AESVLQDAFI
410 420 430 440 450
RLSQSTFPKE AAISISVGNS LTSPAYATQN IMTPQSWSEL PKIVIVQSPD
460 470 480 490 500
GFDNNLEWPG SSLPSMCPWS EGECSSEDHL QDNSSSGKTQ SALEVALACA
510 520 530 540 550
ATVIGTISSP HATEQLKREQ ESINTPTNLV DNEESEELSS QSVNHCTPVD
560 570 580 590 600
YSFPSALCGM TQVASAVAVC GLGEKKDDKY PVTSGGLLSA AETSAAVTLR
610 620 630 640 650
YSIAIGSSME GLNYNIAQML FKEASVVLMK PETYRNVGDF MESMNEKIVQ
660 670 680 690 700
AATKPSVPHL DEIVIDDLAQ NLSNVILTHS VEEVRKKQLN VCSERNLDLH
710 720 730 740 750
TQDVFISTVN KLLFNVLYFT CKKVSDIVQL SECSSTFPED SLSAQVMENQ
760 770 780 790 800
SKETTNDLLE HPPNCSSNKL FNTVSSTNHG KEIVSARSLV KDARREAGLS
810 820 830 840 850
TLESPALHAD VPTRATAHSS SSGKSSPKKK YLKRNMRECY KPIDPNSINQ
860 870 880 890 900
TRKKLQSFTG KDSTTPASER KYGLQELQSS NGKVNRENQE NHTCNVGWHN
910 920 930 940 950
ETQLTMSLLG NPSFPPPQPL LHMKHPPDRY CIADFAEELA ETVVSMATEI
960 970 980 990 1000
AAICLDNSNG KQPWFCSWKR GDDYFMPQAL ACRPVKRKKE TPVVRKHRPP
1010 1020 1030 1040 1050
RLSEIKRKTD EHPELKERLM NRVVDESINL DDILDSSNSF ASEVAAKIMN
1060 1070 1080 1090 1100
LAELSVADNV WQSPNHPRNR LHCDRWSRVN ASSCESIPEE DSDSKGPANT
1110 1120 1130 1140 1150
LGLLNTLGQP MSRTSSVSKQ SSCESITDEF SRFMVNQMEN EGREFDLLLD
1160 1170 1180 1190 1200
YYAGKNANNI LTSALQQVTK KNGHLNVRSG CPSKQSSTES ITDEFYRYML
1210 1220 1230 1240 1250
KEIEKENKEN VTRNSKDWNS NLLPSSQRSP FCFRQSSMPD SRSSASRLTV
1260 1270 1280 1290 1300
NAPIKANSLD GLSRNGHQDS LSVQPISTVS ASGLCKSDSY LYQRCRTDQV
1310 1320 1330 1340 1350
TDMLIHETWA NSIKALMCKN KIIVDDGEVP ELDQHPHNSP PQVQQYANRL
1360 1370 1380 1390 1400
AANIVESGKT LISIHQDSSE RDHATGSNHI PLGMQNISKL IGNRIDLDVK
1410 1420 1430 1440 1450
KEHTSSPGSF PTNHASCSAY LREVPLIQIE TDQREDLDKD SEPVIELTMA
1460 1470 1480 1490 1500
SEETREHLNK EKPSNNSLTT GRCPEPEASM EARAVEVPLS SSDESTGSSW
1510 1520 1530 1540 1550
CQLATEEENP DDTSSFLQLS ERSMSNGNSS TTSSLGIMDL EIYQENMPSS
1560 1570 1580 1590 1600
HTINELVEEK TFRKKEPEKA EEYTSALCEG AANGQKDLLV INCDLEPGCP
1610 1620 1630 1640 1650
DAELRATLQW IAASELGIPT IYFKKSQENR IEKFLDVVQL VHQKSWKVGD
1660 1670 1680
IFHAVVQFCK LHEESRELTP SLFDWLLELG
Length:1,680
Mass (Da):186,283
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFB804C345EDA351
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008104439.1, XM_008106232.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000014888; ENSACAP00000014593; ENSACAG00000014852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100563720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100563720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008104439.1, XM_008106232.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000014593

Genome annotation databases

EnsembliENSACAT00000014888; ENSACAP00000014593; ENSACAG00000014852
GeneIDi100563720
KEGGiacs:100563720

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80309

Phylogenomic databases

eggNOGiENOG502QQ6Q, Eukaryota
GeneTreeiENSGT00940000153313
HOGENOMiCLU_243215_0_0_1
InParanoidiG1KQD8
OMAiNVGHFME
OrthoDBi33853at2759
TreeFamiTF105426

Gene expression databases

BgeeiENSACAG00000014852, Expressed in brain and 8 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR018292, AKAP_110_C
IPR008382, SPHK1-interactor_AKAP_110
PANTHERiPTHR10226, PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716, AKAP_110, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KQD8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KQD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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