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Entry version 83 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotationARBA annotation EC:5.3.4.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein disulfide-isomerase A4UniRule annotation (EC:5.3.4.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDIA4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22UniRule annotationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500513091423 – 641Protein disulfide-isomerase A4UniRule annotationAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi202 ↔ 205Redox-activeUniRule annotation
Disulfide bondi551 ↔ 554Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000014123, Expressed in adrenal gland and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013905

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 165ThioredoxinInterPro annotationAdd BLAST123
Domaini169 – 328ThioredoxinInterPro annotationAdd BLAST160
Domaini501 – 632ThioredoxinInterPro annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 56DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 55Acidic residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationARBA annotation

Keywords - Domaini

Redox-active centerUniRule annotationARBA annotation, RepeatARBA annotation, SignalUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0190, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025879_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KPJ9

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQFWRNK

Database of Orthologous Groups

More...
OrthoDBi
462118at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106382

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03068, PDI_b_ERp72, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005788, Disulphide_isomerase
IPR041866, PDIA4_PDI_b
IPR005792, Prot_disulphide_isomerase
IPR017068, Protein_diS-isomerase_A4
IPR036249, Thioredoxin-like_sf
IPR017937, Thioredoxin_CS
IPR013766, Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00085, Thioredoxin, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036862, Disulphide_isom_A4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 5 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01130, ER_PDI_fam, 1 hit
TIGR01126, pdi_dom, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00194, THIOREDOXIN_1, 3 hits
PS51352, THIOREDOXIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KPJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMRRACLLT LLLAQLVLVA KCQEEEEEEE EAQGEESVFK DDDDDDDDDD
60 70 80 90 100
DTEIKEENGV LVLNDANFDT FVEGKDTVLL EFYAPWCGHC KQFAPEYEKI
110 120 130 140 150
AKTLSENDPP IPVAKIDATS ASTVSGRFDV SGYPTIKILK KGQPVDYEGS
160 170 180 190 200
RTEAEIVAKV KEVSNPDWVP PPDATLVLTK ENFDETVNEA DIILVEFYAP
210 220 230 240 250
WCGHCKRLAP EYEKAAKELR KHTPPISLAK VDAIAETDLA TRFGVSGYPT
260 270 280 290 300
LKIFRKGKSY EYNGPREKYG IVDYMIEQAG PPSKQIQAIK QVQEFVKDGD
310 320 330 340 350
DVIIIGVFKG NQDPAYQLYQ DAANNLREDY KFYHTFSKEI SSFLKVDPGN
360 370 380 390 400
VVVMQPEKFQ SKYEPKMHVL DIKESTDTEE VKSHVVKHAL PLVGHRKTAN
410 420 430 440 450
DAKKYNKKPL VVVYYAVDFS FDYRVATQYW RNKVLEVAKD FPEYTFAVAD
460 470 480 490 500
EEDYSSELKD LELVDSGEDV NAAIFDEGGK KYAMEPEEFD SDVLRQFVLS
510 520 530 540 550
FKKGKLKPIV KSQPVPKNNK GPVKIVVGKT FESIVMDPKK DVLIEFYAPW
560 570 580 590 600
CGHCKKLEPI YTELGKKYKN QKNLVIAKID ATANDVPSEN YKVEGFPTIY
610 620 630 640
FAPSNNKKNP IKLESGERDL ENLSKFVEEH ATKLSRRKEE L
Length:641
Mass (Da):72,764
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37222F7762CB7E98
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003222269.1, XM_003222221.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000014191; ENSACAP00000013905; ENSACAG00000014123

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100565707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100565707

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003222269.1, XM_003222221.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013905

Genome annotation databases

EnsembliENSACAT00000014191; ENSACAP00000013905; ENSACAG00000014123
GeneIDi100565707
KEGGiacs:100565707

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9601

Phylogenomic databases

eggNOGiKOG0190, Eukaryota
GeneTreeiENSGT00940000157738
HOGENOMiCLU_025879_6_2_1
InParanoidiG1KPJ9
OMAiTQFWRNK
OrthoDBi462118at2759
TreeFamiTF106382

Gene expression databases

BgeeiENSACAG00000014123, Expressed in adrenal gland and 15 other tissues

Family and domain databases

CDDicd03068, PDI_b_ERp72, 1 hit
Gene3Di3.40.30.10, 5 hits
InterProiView protein in InterPro
IPR005788, Disulphide_isomerase
IPR041866, PDIA4_PDI_b
IPR005792, Prot_disulphide_isomerase
IPR017068, Protein_diS-isomerase_A4
IPR036249, Thioredoxin-like_sf
IPR017937, Thioredoxin_CS
IPR013766, Thioredoxin_domain
PfamiView protein in Pfam
PF00085, Thioredoxin, 3 hits
PIRSFiPIRSF036862, Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833, SSF52833, 5 hits
TIGRFAMsiTIGR01130, ER_PDI_fam, 1 hit
TIGR01126, pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194, THIOREDOXIN_1, 3 hits
PS51352, THIOREDOXIN_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KPJ9_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KPJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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