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Entry version 72 (07 Apr 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Immunoglobulin mu DNA binding protein 2

Gene

IGHMBP2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri901 – 947AN1-typePROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Immunoglobulin mu DNA binding protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGHMBP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013702, Expressed in female gonad and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini717 – 780R3HInterPro annotationAdd BLAST64
Domaini901 – 947AN1-typeInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni659 – 703DisorderedSequence analysisAdd BLAST45
Regioni847 – 885DisorderedSequence analysisAdd BLAST39
Regioni954 – 1002DisorderedSequence analysisAdd BLAST49

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili14 – 34Sequence analysisAdd BLAST21
Coiled coili322 – 346Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi675 – 695PolyampholyteSequence analysisAdd BLAST21
Compositional biasi868 – 885PolyampholyteSequence analysisAdd BLAST18
Compositional biasi966 – 993PolyampholyteSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.ARBA annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri901 – 947AN1-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1803, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001666_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KP53

Identification of Orthologs from Complete Genome Data

More...
OMAi
RERRCVS

TreeFam database of animal gene trees

More...
TreeFami
TF105388

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18808, SF1_C_Upf1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.50, 1 hit
4.10.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035896, AN1-like_Znf
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR027417, P-loop_NTPase
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR004483, SMUBP-2/Hcs1-like
IPR000058, Znf_AN1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086, AAA_11, 1 hit
PF13087, AAA_12, 1 hit
PF01424, R3H, 1 hit
PF01428, zf-AN1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00393, R3H, 1 hit
SM00154, ZnF_AN1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118310, SSF118310, 1 hit
SSF52540, SSF52540, 1 hit
SSF82708, SSF82708, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00376, TIGR00376, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51061, R3H, 1 hit
PS51039, ZF_AN1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KP53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AMATAVEPFV SRQLELLQEE REAEIAEARV WQESISLKEL ERKGVCLLKL
60 70 80 90 100
EIASQRTGLY GRFLVTLQPR KCGLQAELPS NSFGPGDIVG LYETAGQGDQ
110 120 130 140 150
LSTGIVTRIT AKSVTVAIDE PQSSLLSLDQ GNTYRLLKLA NDVTYKRLKR
160 170 180 190 200
ALNTLSQYRS GPASGLIDVL FCASEPSDAN NTSFSLISPY YPTYSLIQRS
210 220 230 240 250
AGPFTLDKRY STYVRSPLGP LEEIGRNTNR IIIIIIIIRV GFKVLCCAPS
260 270 280 290 300
NIAVDNLVER LASHKARILR LGHPARLLES IQQHSLDAIL AHGDNAQIVA
310 320 330 340 350
DIRKDIDQAF VKNRKTQDKG ERSHFLNEIK TLRKELKERE EMAMTEILTH
360 370 380 390 400
ADVILATNTG ASSDGPLKLL PENHFDMVVI DECSQALEAS CWIPLLKAKK
410 420 430 440 450
CVLAGDHKQL PPTIISHKAA SKGLSLSLME RLIEKYGDRV VKMLTVQYRM
460 470 480 490 500
HQDIMQWAST EMYDGRLLAH HSVAQHLLKD LPGVASTEET SIPLLLIDTA
510 520 530 540 550
GCGLFELDVE DEQSKGNQGE VRLVGLHIQA LVDAGVKARD IAVITPYNLQ
560 570 580 590 600
VDMLRELLCQ NYPELEIKSV DGFQGREKEA VVLSFVRSNR KGEVGFLAED
610 620 630 640 650
RRINVAITRA RRHVAVICDS RTTGNHSFLK RLVDYMNEHG EVRTAFEYLD
660 670 680 690 700
DIVPENYAPK NSQSLSGQGQ KHKCNKAAPK ADGEKPQRKP TKQPEQRPTE
710 720 730 740 750
GLVSNTVRIT TAGPEVKERL CKHKAKILEF LDSSESQLEF PPSLNAHDRL
760 770 780 790 800
LIHQLAEEYG LQHLSLGEGK ERYISIRRKT TATNPTLPKT VATHVSLRDV
810 820 830 840 850
KVCEQELSPK TPSPPREISG HNKERVSSIS MGEIDLKTLH MERIEREKAR
860 870 880 890 900
KKEKAKQSQQ QNVNLQEPGK KHKGKPVVKT RTESAAEEDF DAMISAAVKA
910 920 930 940 950
DNTCGFSKCK ASVTTLGQLC LYCNKRYCLS HHIPEIHGCG EKAKAHARQR
960 970 980 990 1000
ISKEGVLYPG SGSKDKSLDP AKRAHLQRRL DKKLNELTSQ RKSKKKEKYK

GS
Length:1,002
Mass (Da):111,849
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC63662A652876EF4
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013767; ENSACAP00000013489; ENSACAG00000013702

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013489

Genome annotation databases

EnsembliENSACAT00000013767; ENSACAP00000013489; ENSACAG00000013702

Phylogenomic databases

eggNOGiKOG1803, Eukaryota
GeneTreeiENSGT00930000151035
HOGENOMiCLU_001666_5_0_1
InParanoidiG1KP53
OMAiRERRCVS
TreeFamiTF105388

Gene expression databases

BgeeiENSACAG00000013702, Expressed in female gonad and 13 other tissues

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
Gene3Di3.30.1370.50, 1 hit
4.10.1110.10, 1 hit
InterProiView protein in InterPro
IPR035896, AN1-like_Znf
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR027417, P-loop_NTPase
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR004483, SMUBP-2/Hcs1-like
IPR000058, Znf_AN1
PfamiView protein in Pfam
PF13086, AAA_11, 1 hit
PF13087, AAA_12, 1 hit
PF01424, R3H, 1 hit
PF01428, zf-AN1, 1 hit
SMARTiView protein in SMART
SM00393, R3H, 1 hit
SM00154, ZnF_AN1, 1 hit
SUPFAMiSSF118310, SSF118310, 1 hit
SSF52540, SSF52540, 1 hit
SSF82708, SSF82708, 1 hit
TIGRFAMsiTIGR00376, TIGR00376, 1 hit
PROSITEiView protein in PROSITE
PS51061, R3H, 1 hit
PS51039, ZF_AN1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KP53_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KP53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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