UniProtKB - G1KP08 (G1KP08_ANOCA)
Protein
VWFA domain-containing protein
Gene
N/A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- intracellular calcium activated chloride channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ChlorideARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: VWFA domain-containing proteinInterPro annotation |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 886 – 906 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003412817 | 22 – 907 | VWFA domain-containing proteinSequence analysisAdd BLAST | 886 |
Keywords - PTMi
Autocatalytic cleavageARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000013593, Expressed in brain and 1 other tissue |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 304 – 474 | VWFAInterPro annotationAdd BLAST | 171 |
Sequence similaritiesi
Belongs to the CLCR family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QRRD, Eukaryota |
GeneTreei | ENSGT00940000154682 |
HOGENOMi | CLU_005812_0_1_1 |
InParanoidi | G1KP08 |
OMAi | THINMLT |
TreeFami | TF328396 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR004727, CLCA_chordata IPR013642, CLCA_N IPR013783, Ig-like_fold IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF08434, CLCA, 1 hit PF00092, VWA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
TIGRFAMsi | TIGR00868, hCaCC, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KP08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KMEQKWWELF VALLLLLDVK GSLVKLHNGG YEDVVIGIHP KIAENAKIIN
60 70 80 90 100
SIKDMLKEAS SYLFLASQRR FYFRTVKIVI PLTWASKPEY KRASRESYAN
110 120 130 140 150
ADIIVAEPFV KYGDEPYTSQ YGGCGKKGRY IHFTSNFLTN DSLVNIYGSR
160 170 180 190 200
GRILVHEWAH LRWGVFEEYS YDAPFYSTGI NKIEATRCSA SITGQYRFAT
210 220 230 240 250
TGGRTRKCRI ERHTELYEPG CLFIPYKKQT SPASIMFMQS LSSVSQFCDK
260 270 280 290 300
SNHNLMAPNM QNKMCSYKST WEVISGSADF ASSRPLGAPP PDPIIHLMKT
310 320 330 340 350
QYRIVCLVLD ASAQMGKDNR LSRLIQAAKL FLLQIIEEGS WVGIVAFNSK
360 370 380 390 400
GNIQAGLQKV FSDIERESLT SHLPTTAAGD CNICEGVNAA FQVFSQKLTS
410 420 430 440 450
TEGCEIVLLT NGEGSDLSPC LSKIQSQEII IHTIAFGSKA SNELEKLADM
460 470 480 490 500
TGGKTFYATD SLDSNGLIDA FGGISSGSGD ASQQSIQLES KAEKIASMKW
510 520 530 540 550
LQGVVTIDKT VGKDTLFLIA WSSSTSTPEI SLTDPKEKKY LNKDFRIENS
560 570 580 590 600
NIRTARLKIS GTAKTGNWPY SIKNTDSADQ VISLTVTTRA ASATVPPVTV
610 620 630 640 650
KTYISNSNNS FPNPMIIYAD VSQGFLPVIG AKVMATVEST SGKPVELALY
660 670 680 690 700
DEGAGADIIK HDGIYSRYFI AFSDNGRYSI KVNVHGHDKT SRRIHRQNQA
710 720 730 740 750
MYLSGYVDST GGIVLNPPRP VINVTDASFG LGNFDRISSA GSFMVTGVPA
760 770 780 790 800
GGGYKDVFPP NKITDLEVIF NENDEFVLTW TAPGNDYDFG QADRYEIKMS
810 820 830 840 850
GNPLDLTEAN FASATSLDTS ALIPEFSGDK QTFRYEPDEL AKENGTLMYF
860 870 880 890 900
AIRAIDASDN VGEVSNIARA TLLFRAAPPS TSTQPFVVIV LCIAVIGAVL
GLNSVIN
Genome annotation databases
Ensembli | ENSACAT00000013641; ENSACAP00000013369; ENSACAG00000013593 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000013369 |
Genome annotation databases
Ensembli | ENSACAT00000013641; ENSACAP00000013369; ENSACAG00000013593 |
Phylogenomic databases
eggNOGi | ENOG502QRRD, Eukaryota |
GeneTreei | ENSGT00940000154682 |
HOGENOMi | CLU_005812_0_1_1 |
InParanoidi | G1KP08 |
OMAi | THINMLT |
TreeFami | TF328396 |
Gene expression databases
Bgeei | ENSACAG00000013593, Expressed in brain and 1 other tissue |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR004727, CLCA_chordata IPR013642, CLCA_N IPR013783, Ig-like_fold IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF08434, CLCA, 1 hit PF00092, VWA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
TIGRFAMsi | TIGR00868, hCaCC, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KP08_ANOCA | |
Accessioni | G1KP08Primary (citable) accession number: G1KP08 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | October 7, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |