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Entry version 60 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

MRC2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation
LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341335424 – 1396Sequence analysisAdd BLAST1373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi176 ↔ 202PROSITE-ProRule annotation
Disulfide bondi190 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013359, Expressed in hemipenis and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013258

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 189Ricin B-type lectinInterPro annotationAdd BLAST149
Domaini171 – 219Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini233 – 349C-type lectinInterPro annotationAdd BLAST117
Domaini376 – 492C-type lectinInterPro annotationAdd BLAST117
Domaini515 – 622C-type lectinInterPro annotationAdd BLAST108
Domaini665 – 796C-type lectinInterPro annotationAdd BLAST132
Domaini819 – 938C-type lectinInterPro annotationAdd BLAST120
Domaini963 – 1079C-type lectinInterPro annotationAdd BLAST117
Domaini1113 – 1219C-type lectinInterPro annotationAdd BLAST107
Domaini1254 – 1366C-type lectinInterPro annotationAdd BLAST113

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002069_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNV4

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590, CLECT_DC-SIGN_like, 1 hit
cd00062, FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 3 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPATFFRLA LGILVALEVG LCALPSDPGV FLIYSSGLQG CLEAKDSLVK
60 70 80 90 100
IARICNTSLP AQKWKWVSRN RLFNIGTMQC LGVSWKSANT STAAHALATY
110 120 130 140 150
ECDRESITMR WNCRTLGDQL SQYLSSRLGN WTLTPAERGD QARGGQWKIY
160 170 180 190 200
NHDEDLCSRP YSEIYTIQGN SHGKPCTIPF KYDNQWFYDC TSMGRGDGHL
210 220 230 240 250
WCATTQDYGK DERWGFCPIK SNDCDTFWDR DQLTSSCYQF NFQSTLSWQE
260 270 280 290 300
AGKSCEQQGA NLLSITEIHE QTYINGLLTG YGSTLWIGLN DLDLNGGWQW
310 320 330 340 350
SDNSPLKYLN WESDQPDNPN EENCGVIRTE SSGGWQNRDC SMALPYICKK
360 370 380 390 400
KPNATLNTYS VETELKVDCD PSWQPFQTNC YRLISEKKSW LDAKKTCLRS
410 420 430 440 450
EGDLVSIHTL SELEFVTKQI KQDVEELWIG LNDLRLQMNF EWSDGTPVQF
460 470 480 490 500
TFWHPFEPNN FRDSLEDCVT IWGPEGRWND SPCNQTLPSV CKKRGRVSQG
510 520 530 540 550
REDEDHGCRK GWKWHSPSCY WLGVDHVVYS EARKMCMDYG STLVTITNRF
560 570 580 590 600
EQAYVSSLIY GWEDEYFWTA LQDINETGSF HWLSGDEVTY THWNRNQPGY
610 620 630 640 650
NKGGCVALAT GSAMGLWEVK NCINFKAKYI CRQTLGTPVN PELPPPLPTP
660 670 680 690 700
SLTATCPAGW SSNPKLRHCY KVFSYDKLQE KKSWVMAQLY CKDLKAQLLS
710 720 730 740 750
LGSYEEEHFV ANTLNKIFGE SEPEIHEQHW FWIGLNRRDP GSERSWRWSD
760 770 780 790 800
GLGFSYHNFD RSNHDDDDIR NCVALDLASL QWMPLQCEVQ LDWICKLPKG
810 820 830 840 850
TEIKEPETTI QGSNEWVKYQ DAEYKFFDHH STWVQAQRIC TWFQAELVSV
860 870 880 890 900
HSQAELNFLG QNLKKFSRGQ EQHWWIGLNT YENDGRFRWS DDSPLNFILW
910 920 930 940 950
APGKPRPTSK EKKCVYMTAS REDWGDQKCL TDLPYICKRS NRTTLPSVPV
960 970 980 990 1000
PTPGSCAQGW HELSNKCFRI HSQEQVIWPE AKRKCEIQGG MLATVSNHLE
1010 1020 1030 1040 1050
QAFITTLLPN ITCDLWIGFH DAKKEFQWVE SELVQYVNWA PGEPSGYKTS
1060 1070 1080 1090 1100
TASDNPTNCA IVWHGYPSLF TGRWDDRNCL EEKHGFICQR SKDPTLSPSP
1110 1120 1130 1140 1150
ATFSPAPNAT LSYLNCTYRI LKKPLKWHDA VLLCESLNAS LVNVMEPYTQ
1160 1170 1180 1190 1200
AYLTQAISSV RAPLWIGLSK EEARRSYVWF TEESLSYTNW QDGEPQQLIG
1210 1220 1230 1240 1250
CTYMDVDGTW RTASCDSKLQ GAICKMNAGP VSSHKWSYNG SCPKSVEDSS
1260 1270 1280 1290 1300
WIPFRNHCYA FHMEAVIGQK EAMKRCQKVG GSVLSILDEI ENVFIWEHLE
1310 1320 1330 1340 1350
YSGGQSKGAW LGMAFNPKGG TLVWHDNMAV NYSNWGQHDT GPSMLSPNSC
1360 1370 1380 1390
YWIQKSNGVW HLGSCSNVTM GVICKTARGK QGAKQQDWPS LSCSGV
Length:1,396
Mass (Da):159,367
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5361B039DBC0A3A2
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013525; ENSACAP00000013258; ENSACAG00000013359

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013258

Genome annotation databases

EnsembliENSACAT00000013525; ENSACAP00000013258; ENSACAG00000013359

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00990000203637
HOGENOMiCLU_002069_2_0_1
InParanoidiG1KNV4
TreeFamiTF316663

Gene expression databases

BgeeiENSACAG00000013359, Expressed in hemipenis and 11 other tissues

Family and domain databases

CDDicd03590, CLECT_DC-SIGN_like, 1 hit
cd00062, FN2, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit
SUPFAMiSSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 3 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNV4_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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