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Entry version 52 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Glutamate receptor interacting protein 2

Gene

GRIP2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glutamate receptor interacting protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013280, Expressed in hindlimb bud and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013176

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 54PDZInterPro annotationAdd BLAST46
Domaini99 – 185PDZInterPro annotationAdd BLAST87
Domaini199 – 283PDZInterPro annotationAdd BLAST85
Domaini412 – 487PDZInterPro annotationAdd BLAST76
Domaini513 – 599PDZInterPro annotationAdd BLAST87
Domaini614 – 696PDZInterPro annotationAdd BLAST83
Domaini947 – 1029PDZInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni699 – 727DisorderedSequence analysisAdd BLAST29
Regioni774 – 817DisorderedSequence analysisAdd BLAST44
Regioni891 – 922DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi906 – 920PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004313_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNR0

TreeFam database of animal gene trees

More...
TreeFami
TF326909

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043545, GRIP1/2
IPR030029, GRIP2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46227, PTHR46227, 1 hit
PTHR46227:SF4, PTHR46227:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 5 hits
PF17820, PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PEEFRGVTIV ELIKKEGSTL GLTISGGTDK DGPRVSNLRP GGLAASQETL
60 70 80 90 100
SPGEFWVDLS VFSILSLNLG LQKKADINSP FSLSLAPDNS AGIIPKTIDV
110 120 130 140 150
TLYKEGNSFG FVLRGGAHED WHKSRPLVLT YVRPGGPADR EGSLKVGDRL
160 170 180 190 200
LSVDGIPLHS VSHADALNIL RQCNQEALFQ IEYDVTIMDT VANASGPLLV
210 220 230 240 250
EIAKTPGSAL GITLALNSHR NKQVIIIDKI KPASVVDRCG ALHIGDHILS
260 270 280 290 300
IDGTSTEHCS LLEATQLLAA TSENVKLEIL PAHQSRLPLK PPDTVKVQKS
310 320 330 340 350
DHHHCWDPCV NYCHTHHPGH CKTPTWNQTT SQHPSVHLPA TSLPPDSNLS
360 370 380 390 400
FFLFSVSSLN NSNTLPRSNH TMSPRATMLR RRQRKKEHKS SLSLASSTIG
410 420 430 440 450
PGGQIVHTEI TEVILRGDPL NGFGLQLQGG IFATETLSSP PLIRFIEPDS
460 470 480 490 500
PAERCGLLQV GDRVLSINSI ATEDGTMEEA NQLLRDAALT NKVVLEIEFD
510 520 530 540 550
VAESVIPSSG TFHVKLPKKR GVELGITISC RTASRKSGEP LIISDIKKGS
560 570 580 590 600
VAHRTGTLEP GDKLLAIDNI RLDNCSMEDA VQILKQCEEL VKLKIRKDED
610 620 630 640 650
NSDEQETTGA IIYTVELKRY GGPLGITISG TEEPFDPIVI SGLTKRGLAE
660 670 680 690 700
RTGAIHVGDR ILAINNVSLK GKPLSEAIHL LQMAGETVTL KIKKQTEMNQ
710 720 730 740 750
GTYPKKSGSM NEVSDPEDDL TDSQKTSKLS EIYSTTIPSV DSAMESWDGS
760 770 780 790 800
GIDAGYGSQD ITFQAVGIAL HPHEWRSSRQ KSSTPPGDPR KSYPFMDGSF
810 820 830 840 850
SEDDWEKPSR YPNRQNGLET AHEDNFWRVF GEALEDLETC GQSELLREIE
860 870 880 890 900
AFEKHSRPGS LLELLIYASI MTGSVHNLGL DGGKLLLNSV NQTGLSPPRK
910 920 930 940 950
GNTKSPGDGQ GISNGTPTKK NDRNLEIKMM KEEIQEIMSP TPLELHKMTI
960 970 980 990 1000
YKDPETEDFG FSVSDGLLEK GVYVNMIRPD GPADQCGLKP YDRVLQVNRI
1010 1020 1030 1040 1050
RTRDLDCCLA VPLISEAGDK LDLVISRNPL AFMANTQLDD HRDLLGVEGK

ANTQTL
Length:1,056
Mass (Da):115,151
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7433B787F664B1EC
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013439; ENSACAP00000013176; ENSACAG00000013280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013176

Genome annotation databases

EnsembliENSACAT00000013439; ENSACAP00000013176; ENSACAG00000013280

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00940000155615
HOGENOMiCLU_004313_0_0_1
InParanoidiG1KNR0
TreeFamiTF326909

Gene expression databases

BgeeiENSACAG00000013280, Expressed in hindlimb bud and 12 other tissues

Family and domain databases

Gene3Di2.30.42.10, 7 hits
InterProiView protein in InterPro
IPR043545, GRIP1/2
IPR030029, GRIP2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
PANTHERiPTHR46227, PTHR46227, 1 hit
PTHR46227:SF4, PTHR46227:SF4, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 5 hits
PF17820, PDZ_6, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 6 hits
SUPFAMiSSF50156, SSF50156, 7 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNR0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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