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Entry version 56 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein

USP domain-containing protein

Gene

USP53

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
USP domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP53Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013366, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013171

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 351USPInterPro annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni376 – 666DisorderedSequence analysisAdd BLAST291
Regioni798 – 817DisorderedSequence analysisAdd BLAST20
Regioni1084 – 1105DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi385 – 403PolyampholyteSequence analysisAdd BLAST19
Compositional biasi404 – 424PolarSequence analysisAdd BLAST21
Compositional biasi433 – 452PolyampholyteSequence analysisAdd BLAST20
Compositional biasi460 – 482PolyampholyteSequence analysisAdd BLAST23
Compositional biasi486 – 508PolarSequence analysisAdd BLAST23
Compositional biasi559 – 582PolyampholyteSequence analysisAdd BLAST24
Compositional biasi590 – 621PolyampholyteSequence analysisAdd BLAST32
Compositional biasi622 – 651PolarSequence analysisAdd BLAST30
Compositional biasi652 – 666PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1887, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_287278_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNQ7

Database of Orthologous Groups

More...
OrthoDBi
101145at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323194

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR040143, USP53
IPR028889, USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22975:SF6, PTHR22975:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWVKFLRKP GGNLGKVYQP GSVMSLAPTK GLLNEPGQNS CFLNSAVQVL
60 70 80 90 100
WQLDIFRRSL RGLTGHVCQG DACIFCALKT IFTQFQHSRE KALPSNNMRH
110 120 130 140 150
ALAESFKDEQ RFQLGFMDDA AECFENILER IHYHIVPSSE TDMCTSKSCI
160 170 180 190 200
THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVDRMFERH
210 220 230 240 250
ERLKPEMFAE LLQAANTTDD FRNCPSNCGQ KIKIRRVLMN CPEIVTIGLV
260 270 280 290 300
WDSEHSDLTE DVIRNLATQL YLPGLFYRVT DERAKNSELF LVGMICYASK
310 320 330 340 350
HYCAFAFHTK SCKWVLFDDA NVKEVGTKWK DVVSKCIRCH FQPLLLFYAN
360 370 380 390 400
PDGTPVSTED APRQIIHWSH YKASAGNGEE SGFEKTTFPK SDHTKENGFE
410 420 430 440 450
ESVIQKNTKK IQPEHSSLNR NHVQYGGVRG SGKLGHSEHR EKAKDISREC
460 470 480 490 500
AQKVAEMKNI SSSFRKDVDR GSKRESGKQK DVQTHFKPGS PPSGNGFRPH
510 520 530 540 550
SNERLYNSQG RGPYKHEKVH NQIRPTAQVL GSSKTDGFTD GEKMSRMKSD
560 570 580 590 600
SVTGYETDSS QDSKDKGSVS SSKSRSRGWK PMRETLNVDS IFSESEKKEH
610 620 630 640 650
SSKTKLNANS RPKHEKEISS NNWPKENVSQ KALMTIYEDE TKQTGNRNSF
660 670 680 690 700
DSEGKENAEK SKGFTDRKVH IDSWQIQRTE SGYESSDHIS NASANLDSPI
710 720 730 740 750
IEGTSPVDNA VPKENTSYSD QNLSVRYSGC VLQSTSQQNK NSLDGLKKDQ
760 770 780 790 800
ANTHINYRPH NASSLSHLQM HSPPLKRTGI PDCNKKFFPL TLQSTLKDHS
810 820 830 840 850
EKGTKNSVLS EQNNGRWPKD HVLDETTMPV HSVESLASSY NGENPTMAER
860 870 880 890 900
ILNKESLSSQ SQLSQTRTMR SKPALAFFLQ QNISKPSYSE SVPSVEHKIP
910 920 930 940 950
LYGSKTDDTA EAIYQNLPPP LPPKKYTLTS LHGLEQDSTV DPKVTEVPCT
960 970 980 990 1000
NPSNIERHLA SVPSKATPEA NSFADEERVK ASFHGNESSK TDFPTSLSGN
1010 1020 1030 1040 1050
DLWALSSHPT NKGTCLMGTR ASSLDANAND IVSLTTYFSV DNCMTDTYRL
1060 1070 1080 1090 1100
KYHQRPKLYF VDSSVLSKET SAVHLNPSYH STCESDYPTP EQRHKPSIGN

VYCNR
Length:1,105
Mass (Da):124,104
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i375A0344EFCEF0F5
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003221824.1, XM_003221776.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013434; ENSACAP00000013171; ENSACAG00000013366

Database of genes from NCBI RefSeq genomes

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GeneIDi
100560654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100560654

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003221824.1, XM_003221776.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013171

Protein family/group databases

MEROPSiC19.081

Genome annotation databases

EnsembliENSACAT00000013434; ENSACAP00000013171; ENSACAG00000013366
GeneIDi100560654
KEGGiacs:100560654

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54532

Phylogenomic databases

eggNOGiKOG1887, Eukaryota
GeneTreeiENSGT00940000156337
HOGENOMiCLU_287278_0_0_1
InParanoidiG1KNQ7
OrthoDBi101145at2759
TreeFamiTF323194

Gene expression databases

BgeeiENSACAG00000013366, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR040143, USP53
IPR028889, USP_dom
PANTHERiPTHR22975:SF6, PTHR22975:SF6, 1 hit
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNQ7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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