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Entry version 57 (07 Oct 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

NBR1 autophagy cargo receptor

Gene

NBR1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NBR1 autophagy cargo receptorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NBR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleARBA annotation, LysosomeARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013331, Expressed in hemipenis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013162

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 85PB1InterPro annotationAdd BLAST82
Domaini208 – 254ZZ-typeInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 638DisorderedSequence analysisAdd BLAST66
Regioni680 – 702DisorderedSequence analysisAdd BLAST23
Regioni833 – 858DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 81Sequence analysisAdd BLAST21
Coiled coili283 – 324Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi573 – 598PolarSequence analysisAdd BLAST26
Compositional biasi680 – 700PolarSequence analysisAdd BLAST21
Compositional biasi833 – 851PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4351, Eukaryota
KOG4582, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014175_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNQ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSENTTW

TreeFam database of animal gene trees

More...
TreeFami
TF328428

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14947, NBR1_like, 1 hit
cd06396, PB1_NBR1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR033513, NBR1
IPR000270, PB1_dom
IPR034852, PB1_NBR1
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR20930:SF2, PTHR20930:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745, PB1, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPQVKLNVT FQNDTQSFLV SDSASTTWAD VEAMVKVSFE LNEIQIKYLD
60 70 80 90 100
EDHDEVSVNT AEEYEEALKI AVKQGNQLQM NVYELSTAPD MLPQQAPETS
110 120 130 140 150
VVHKDGRKPL SHYSSLARTL AQGKVMEKER EQPLITDRCE SGPHLSEAPP
160 170 180 190 200
EWFTSYLEKF REQVVQETVE MLEQKLNEKL LLSSQPPSSL SSSTHQAPVS
210 220 230 240 250
PPVQSNPFDW LLSCSNCQAP IVGIRYQCSV CPSYSICELC EAGAYAHDPN
260 270 280 290 300
HVLLKLRRPI LCISESYNLG QFSPRLATLE QVRLQKQMDK RFLKAEKQRL
310 320 330 340 350
RAEKKQRKAE VRELKKQLKL HRKIHLWNSS HALENTSLTV TKTENLQSST
360 370 380 390 400
LLPLQGCPVI VPTLSAAFVD ENLPDGTCLK PRTTFIKHWR MRNTGNMEWS
410 420 430 440 450
SDTKLKFMWG NLTLLSSEKK DVIVPFLLPG QVGVVSVQFV SPAVEGTYTS
460 470 480 490 500
HWRLSHRGEQ FGPRIWCSIV VDPNSSNTGC TDSCKLVSTF CQKGRSLCKE
510 520 530 540 550
EERLSKFKAE ALQAVDSAMQ GGLVSRAAPT NVKSILSARE FYIPSVDLLT
560 570 580 590 600
AQDLLSFELL DINIVQELEQ VPRNTPVDTT PDMSVLPHDS SPLDNTSLDQ
610 620 630 640 650
KQEEMEENTC KQLPADALMG KGKTENSANQ EEAEEDMSGR QFVCETVIRS
660 670 680 690 700
LTLDAAPDHR PPQRKKSLQG SLQTLQDTIL YSPKSKDPIS PVSTPKEPES
710 720 730 740 750
SNRGMEIAKE LDFGLWVITE LAWLMHSNIY INHRIVLEDY RHILTDLFLK
760 770 780 790 800
ASFICGFSTF HETLCRPLET PVQCCTLSAR LEKAAETSAH PEGVSHLPVQ
810 820 830 840 850
NINDMLTTSQ TLDEVPLIPQ IVELQPTRIG KSSFSCQRKS HNNSSPASNA
860 870 880 890 900
PNREEAPLIP EQMRGMKRSR KHAQNSPAFS FQHLYRHTQG NSIAGGLVKG
910 920 930 940 950
ALSVAASAYK ALFAGPPSLD QALPVTTEDH MATFLANLSE MGFRDRHLNL
960 970 980
RLLRKHNCDM AQVVTELLQL SHSDWYESQY
Length:980
Mass (Da):110,001
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAE79096616AF7AC
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013424; ENSACAP00000013162; ENSACAG00000013331

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013162

Genome annotation databases

EnsembliENSACAT00000013424; ENSACAP00000013162; ENSACAG00000013331

Phylogenomic databases

eggNOGiKOG4351, Eukaryota
KOG4582, Eukaryota
GeneTreeiENSGT00390000016335
HOGENOMiCLU_014175_0_0_1
InParanoidiG1KNQ0
OMAiDSENTTW
TreeFamiTF328428

Gene expression databases

BgeeiENSACAG00000013331, Expressed in hemipenis and 14 other tissues

Family and domain databases

CDDicd14947, NBR1_like, 1 hit
cd06396, PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR033513, NBR1
IPR000270, PB1_dom
IPR034852, PB1_NBR1
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PANTHERiPTHR20930:SF2, PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745, PB1, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNQ0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 7, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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