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Entry version 48 (07 Oct 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi93 – 152HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi415 – 474HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013315, Expressed in forelimb bud and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 151HomeoboxInterPro annotationAdd BLAST61
Domaini163 – 191C2H2-typeInterPro annotationAdd BLAST29
Domaini413 – 473HomeoboxInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 98DisorderedSequence analysisAdd BLAST52
Regioni294 – 346DisorderedSequence analysisAdd BLAST53
Regioni362 – 409DisorderedSequence analysisAdd BLAST48
Regioni604 – 702DisorderedSequence analysisAdd BLAST99
Regioni810 – 868DisorderedSequence analysisAdd BLAST59
Regioni972 – 991DisorderedSequence analysisAdd BLAST20
Regioni1041 – 1063DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 62PolarSequence analysisAdd BLAST16
Compositional biasi64 – 98PolyampholyteSequence analysisAdd BLAST35
Compositional biasi389 – 406PolarSequence analysisAdd BLAST18
Compositional biasi604 – 642PolarSequence analysisAdd BLAST39
Compositional biasi680 – 702PolyampholyteSequence analysisAdd BLAST23
Compositional biasi810 – 841PolarSequence analysisAdd BLAST32
Compositional biasi842 – 867PolyampholyteSequence analysisAdd BLAST26
Compositional biasi974 – 991PolarSequence analysisAdd BLAST18
Compositional biasi1041 – 1056PolarSequence analysisAdd BLAST16

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1146, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003133_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNL6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMASHES

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 2 hits
SM00355, ZnF_C2H2, 4 hits
SM00451, ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 2 hits
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHFLAAQNQF LHSQFLERPM DMPYMIFDPN SPLMTGQLLN SSLAQMTPQV
60 70 80 90 100
GSGHSAHHTA SISGSLKRKL DDKDDNNCSE KEGGNSGEDQ HRDKRLRTTI
110 120 130 140 150
TPEQLEILYE KYLLDSNPTR KMLDHIAREV GLKKRVVQVW FQNTRARERK
160 170 180 190 200
GQFRAVGPAQ SHKRCPFCRA LFKAKSALES HIRSRHWNEG KQAGYSLPPS
210 220 230 240 250
PLIANEEEGE SPQKYTFFDY SSLTLTKIDL SSENELASTV STPVSKTAEM
260 270 280 290 300
SPKHLLSPSF KAECNEDIEN LSITPVDAGF DQNKTDFDET SSINTAISDA
310 320 330 340 350
TTDEGNNEME NMTSSSGDVK SSSSLKEPKN ILNDNLPKNT NMPNVESSDD
360 370 380 390 400
KFLFSLTSPS IQFSDKDGDQ DQSFYITDDP DDNADRSETS SIADPSSPNP
410 420 430 440 450
FGANFKSKST DRLGHKRFRT QMSNLQLKVL KACFSDYRTP TMQECEMLGN
460 470 480 490 500
EIGLPKRVVQ VWFQNARAKE KKFKINIGKP FMINQNATDG SRPECSLCGV
510 520 530 540 550
KYSARLSIRD HIFSKQHITK VRETLGSQLD REKDYLAPTT VRQLMAQQEL
560 570 580 590 600
DRIKKATDVL GLTVQQPGMM DSSSLHGISL PAAYPGLPGL PPVLLPGMNG
610 620 630 640 650
PSSLTGFPQS SNTLTSPSAS MLGFPSSATS SPALSLSSAP SKPLLQTPPP
660 670 680 690 700
PPPTSSLSGQ QTEQQNKESE KKHTNKSHKV KKIKEEELEG NKPEKHHKKE
710 720 730 740 750
EKISSALSVL GKVVGESHVD PNQLQALQNA IAGDPASFIG GQFLPYFIPG
760 770 780 790 800
FASYFTPQLP GTVQGGYLPP VCGMESLFPY GPAVPQTIAG LSPGTLLQQY
810 820 830 840 850
QQYQQNLQDS LQKQQKQQEQ QQKQGQAKSS KVENDQPQNS SDASETKEDR
860 870 880 890 900
SSATESTKEE PQLDSKSADF SDSHIVPFVK YEFICRKCQM MFTDEDAAVN
910 920 930 940 950
HQKSFCYFGQ PMIDPQETVL RVPVSKYQCL ACDVAISGNE ALSQHLQSSL
960 970 980 990 1000
HKEKTIKQAM RNAKEHVRLL PHSVCSPNPN TTSTSQSAAS SNNTYPHLSC
1010 1020 1030 1040 1050
FSMKSWPNIL FQASARKAAS SPSSPPSLSL PSTVTSSLCS TSGVQTSLPT
1060 1070 1080 1090
ESCSDESDSE LSQKLEDLDN SLEVKAKPAS GLDGNFNSIR MDMFSV
Length:1,096
Mass (Da):120,749
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A6B9A83C80396D1
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013365; ENSACAP00000013105; ENSACAG00000013315

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013105

Genome annotation databases

EnsembliENSACAT00000013365; ENSACAP00000013105; ENSACAG00000013315

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
GeneTreeiENSGT00940000159542
HOGENOMiCLU_003133_0_0_1
InParanoidiG1KNL6
OMAiFMASHES

Gene expression databases

BgeeiENSACAG00000013315, Expressed in forelimb bud and 13 other tissues

Family and domain databases

CDDicd00086, homeodomain, 2 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 2 hits
SM00355, ZnF_C2H2, 4 hits
SM00451, ZnF_U1, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 2 hits
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNL6_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 7, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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