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Entry version 57 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

TANC2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013237, Expressed in forelimb bud and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013093

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini937 – 1305ANK_REP_REGIONInterPro annotationAdd BLAST369
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati992 – 1024ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1108 – 1140ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1141 – 1173ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1174 – 1206ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1207 – 1239ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1240 – 1272ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1329 – 1443TPR_REGIONInterPro annotationAdd BLAST115
Repeati1329 – 1362TPRPROSITE-ProRule annotationAdd BLAST34
Repeati1376 – 1409TPRPROSITE-ProRule annotationAdd BLAST34
Repeati1410 – 1443TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 55DisorderedSequence analysisAdd BLAST55
Regioni189 – 228DisorderedSequence analysisAdd BLAST40
Regioni492 – 516DisorderedSequence analysisAdd BLAST25
Regioni1506 – 1657DisorderedSequence analysisAdd BLAST152
Regioni1901 – 1921DisorderedSequence analysisAdd BLAST21
Regioni2045 – 2069DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1443 – 1463Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 34Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi35 – 53Polar residuesSequence analysisAdd BLAST19
Compositional biasi492 – 506Polar residuesSequence analysisAdd BLAST15
Compositional biasi1506 – 1589Polar residuesSequence analysisAdd BLAST84
Compositional biasi1627 – 1657Polar residuesSequence analysisAdd BLAST31
Compositional biasi1902 – 1916Polar residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001464_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KNK8

TreeFam database of animal gene trees

More...
TreeFami
TF323159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027417, P-loop_NTPase
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 3 hits
PF13181, TPR_8, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 11 hits
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KNK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRNSLKMLL TGGKSNRKNR SSDGGSEEQA DRRQTSIDYC QSHSGQGGSS
60 70 80 90 100
TENDCAFEPE YAIPALPVPE GMQHIRIMEG MSRSLPSSPL LTHQSISVRL
110 120 130 140 150
QPMKKLTAPL RKAKFVESPR IPESELGSPT LTSAPKLDLD AYCPGEAEPE
160 170 180 190 200
LGPPPSVDEA ANTLMTRLGF LLGEKVNEVQ AGHQYSMEVQ EDNQTSAASQ
210 220 230 240 250
RISPCSTLTS STASPPASSP CSTLPQSSTK DVIAKDGTYG AVTSPTSTLE
260 270 280 290 300
SRDSGIIATL TSYSENMDRA KYGGESSKEL GSGGNLKPWQ SQKSSIDSCL
310 320 330 340 350
YRVDENMTAS TYSLNKIPER NLETVLSQSV QSIPLYLMPR PNSVAATSSA
360 370 380 390 400
HLEDLAYLDE QRHAPLRTSL RMPRQSMAGA RTQQDLRVRF APYRPPDISL
410 420 430 440 450
KPLLFEVPSI TTESVFVGRD WVFQEIDVQL QSADASVNRG VVIVGNIGFG
460 470 480 490 500
KTAIISRLVA LSCHGTRMRQ IASDSPHASP KHVDANRELP LTQQPSAHSS
510 520 530 540 550
IASGSCPGTP EMRRRQEEAM RRLAAQVVAY HYCQADNAYT CLVPEFVHNV
560 570 580 590 600
AALLCRSPQL VAYREQLLRE PHLQSMLSLR SCVQDPLASF RRGVLEPLEN
610 620 630 640 650
LHKERKIPNE DFIILIDGLN EAEFHKPDYG DTIVSFLSKT IGKFPSWLKL
660 670 680 690 700
IVTVRTSLQE IIKLLPFHRI FLDRLEENEA IDQDLQAYIL HRIHSSSEIQ
710 720 730 740 750
NNISLNGKMD NTTFGKLSSH LKTLSQGSYL YLKLTFDLIE KGYLVLKSSS
760 770 780 790 800
YKVVPVSLSE VYLLQCNMKF PTQSSFDRVM PLLNVAVASL HPLTDEHIFQ
810 820 830 840 850
AINAGSIEGT LEWEDFQQRM ENLSMFLIKR RDMTRMFVHP SFREWLIWRE
860 870 880 890 900
EGEKTKFLCD PRSGHTLLAF WFSRQEGKLN RQQTIELGHH ILKAHIFKGL
910 920 930 940 950
SKKVGVSSSI LQGLWISYSS EGLSMALASL RNLYTPNIKV SRLLILGGAN
960 970 980 990 1000
INYRTEVLNN APILCVQSHL GYTEMVALLL EFGANVDASS ESGLTSLGYA
1010 1020 1030 1040 1050
AAAGYLSIVA LLCKKRAKVD HLDKNGQCAL VHAALRGHLE VVKFLIQCDW
1060 1070 1080 1090 1100
TMAGQQQGVF KKSQAIQQAL IAAASMGYTE IVSYLLDLPE KDEEEVERAQ
1110 1120 1130 1140 1150
INSFDSLWGE TALTAAAGRG KLEVCRLLLE QGAAVAQPNR RGVVPLFSAV
1160 1170 1180 1190 1200
RQGHWQIVDL LLTHGADVNM ADKQGRTPLM MAASEGHLST VEFLLSQGSS
1210 1220 1230 1240 1250
ISLMDKEGLT ALSWACLKGH LSVVRALVES GAATDHADKN GRTPLDLAAF
1260 1270 1280 1290 1300
YGDAEVVQFL VDHGAMIEHV DYSGMRPLDR AVGCRNTSVV VTLLKKGAKI
1310 1320 1330 1340 1350
GCQTLPSRPR GPATWAMATS KPDIMVILLS KLMEEGDMFY KKGKVKEAAQ
1360 1370 1380 1390 1400
RYQYALKKFP REGFGEDLKT FRELKVSLLL NLSRCRRKMN DFGMAEEFAT
1410 1420 1430 1440 1450
KALELKPKSY EAYYARARAK RSSRQFSAAL EDLNEAIKLC PNNREIQRLL
1460 1470 1480 1490 1500
MRVEEECRQS QAQLQQQPLV VSEPETQHEE LYEVQDILEE EYIEQDVENI
1510 1520 1530 1540 1550
SVGLQTESRP SQTLPIIQSP PSSPAHRDSA YISSSPLGSH QVFDFRSNSS
1560 1570 1580 1590 1600
VGSPTRQGYQ PTSPALSPTH QNSHYRPSPP HTSPAHQASY RFSPPPVGSQ
1610 1620 1630 1640 1650
GKEYQSPPPS PLRRGPQYRA SPPAESMSVY RAQSGSPVRY PQEPSISQLP
1660 1670 1680 1690 1700
SRPKSPLSKM TQRSFQMLPL PVAVPQQGLR LQPAKAQIVR SNQQSSAVHC
1710 1720 1730 1740 1750
STVIPTGTYG QVSHSVASKY QSPSAEMAVS QSRLVYQSSV GGIVGDGRPV
1760 1770 1780 1790 1800
QHVQASLSAG AICQHGGLAK EDLPQRPSSA YRGGMRYSQT PQIGRSQSAS
1810 1820 1830 1840 1850
YYPVCHAKLD LERSSLPSTQ LGSPDISHLI RRQMTVNPNE IKPHPPTPRP
1860 1870 1880 1890 1900
LLHSQSVGLR FSPSSNSISS TPNLNPPFRP SASIQQMEIP LKPAYDRSCD
1910 1920 1930 1940 1950
ELSPVSPTQG GYPSEPARSR TTPFMGIIDK TARTQQYPHL HQQNRTWAVS
1960 1970 1980 1990 2000
SVDTVISPTS PGNLPQQETF SPPSSISSIA FYNKTNNAQN GHLLEDDYYS
2010 2020 2030 2040 2050
PHGMLANGSR GDLLERVTQT SSYPDVKVAR TLPVAQAYQD NLYRQLSRDS
2060
RQGQTSPIKP KRPFVESNV
Length:2,069
Mass (Da):228,582
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB86986E189116914
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013353; ENSACAP00000013093; ENSACAG00000013237

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013093

Genome annotation databases

EnsembliENSACAT00000013353; ENSACAP00000013093; ENSACAG00000013237

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000156447
HOGENOMiCLU_001464_0_1_1
InParanoidiG1KNK8
TreeFamiTF323159

Gene expression databases

BgeeiENSACAG00000013237, Expressed in forelimb bud and 11 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027417, P-loop_NTPase
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 3 hits
PF13181, TPR_8, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 11 hits
SM00028, TPR, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KNK8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KNK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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