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Entry version 66 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

FGD6

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1212 – 1271FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGD6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000012933, Expressed in heart and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012764

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini861 – 1050DHInterPro annotationAdd BLAST190
Domaini1079 – 1173PHInterPro annotationAdd BLAST95
Domaini1212 – 1271FYVE-typeInterPro annotationAdd BLAST60
Domaini1324 – 1420PHInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni52 – 84DisorderedSequence analysisAdd BLAST33
Regioni263 – 284DisorderedSequence analysisAdd BLAST22
Regioni475 – 507DisorderedSequence analysisAdd BLAST33
Regioni577 – 627DisorderedSequence analysisAdd BLAST51
Regioni652 – 721DisorderedSequence analysisAdd BLAST70
Regioni827 – 852DisorderedSequence analysisAdd BLAST26
Regioni1186 – 1206DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi476 – 498PolyampholyteSequence analysisAdd BLAST23
Compositional biasi580 – 602PolarSequence analysisAdd BLAST23
Compositional biasi605 – 626PolyampholyteSequence analysisAdd BLAST22
Compositional biasi652 – 679PolarSequence analysisAdd BLAST28
Compositional biasi706 – 721PolarSequence analysisAdd BLAST16
Compositional biasi1186 – 1201PolyampholyteSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1212 – 1271FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1729, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156334

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004959_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KN38

Database of Orthologous Groups

More...
OrthoDBi
652460at2759

TreeFam database of animal gene trees

More...
TreeFami
TF343077

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15793, PH1_FGD6, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR037743, FGD6_N_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 2 hits
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KN38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAAEVKKP PVAPKPKFVI GHKVGPPPVA PKPDVVLADV LQATKKTKPA
60 70 80 90 100
IAPKPKVLKC SSDPETKAAP SPLRKNSKSL EEHKRDSSEY LVHLNYKNGA
110 120 130 140 150
PRDNTAYIIS VCSCNFECIH KLGNGGSTCK NPTIFEQLEN LENIDIGEPL
160 170 180 190 200
SSLKPRIIFD SHNEKNINKN RVVLKANLLE EKLKDVLTQS VFPNCSHLRQ
210 220 230 240 250
KPLSKLEKGN IHSHNNDVKI EFTDLIPPSE DVAVNPSNIK LDDVKPEMCQ
260 270 280 290 300
VLPLGENMNG CFSLSDPSTS DTNDLQTSTS SKESNEFLAS FGTSPAPSVK
310 320 330 340 350
SLPVPKPRKL RTPCLVRQDG IDIPGDKIKE TSALENGSEL STCAVKKTPK
360 370 380 390 400
VSVLAQSVSY NNQEPMFSGN KSEIVLGLAG KMLPTSEPDD SKELNPEKLS
410 420 430 440 450
PKILHKTSYP VENVEHSLDL YSTNPSENIM DEDNSMLAAH DENTDFVRCS
460 470 480 490 500
NLSMSLPKQL KLSCNQHLPA FEILGDSAQK KEDKDTHLKG ESSPKTIPKK
510 520 530 540 550
PQRHSIPAAG LLKKAASEEL LERSAYGEGH SETPPEGSRI RHLSAKEQRS
560 570 580 590 600
LLSCDAPKPA LEKPVWKLPH PILPFPSNPE ALKNTKNAKN SERTSAVTKP
610 620 630 640 650
RAKSLSSVDM DRIHKPPKDP QKKNSLKKFL NMKLSISIMK TDFHKFLTKS
660 670 680 690 700
SQPVDNSTVA FSSQEEPGKN QNVTRMTNGR KMKSPKVHSA EMGGLASEKG
710 720 730 740 750
KQKSRGQNDT TSSQRSKSLD EQVIASQGHL NSLANDYMPE YENMSHYEEI
760 770 780 790 800
PEYENLPFVA IDKNPCFKWQ RSNTAEDQDA DLYEAQDLYE PTRNCSEFSR
810 820 830 840 850
SSAEELDGSD LILEDVHSDD DLMLRDVNSS DEDADTNSDS SKGELDTQEN
860 870 880 890 900
KQIKAAGKKT KVYHIAKEIM SSEKVFVDVL KLLHIDFRDA VAHASRQLGK
910 920 930 940 950
PIIEDRILNQ ILTYLPQLYE LNRDLLRELE ERLSHWVDHQ RIADIFMKKG
960 970 980 990 1000
PYLKMYSTYI KEFERNITLL EEQCKKNPGF AAVVRDFETS PRCAHLALKH
1010 1020 1030 1040 1050
YLLKPVQRIP QYRLLLTDYL KNLLEDSADF RDTQGALAIV IEVANHANDI
1060 1070 1080 1090 1100
MKQGDNFQKL MQIQYSLNGH HEIVQPGRVF LKEGTLMKLS RKVMQPRMFF
1110 1120 1130 1140 1150
LFNDALLYTT PVQSGMYKLN NMLSLAGMKV RKPTHEAYQN ELNIESVERS
1160 1170 1180 1190 1200
FILSASSATE RDEWLEAISK AIEDYTKKRI TFNPSKSLEE ADPEKDQEDS
1210 1220 1230 1240 1250
PVGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKV ICQACSSNKH
1260 1270 1280 1290 1300
RLDYMKNHPA RVCDHCFKEL QKQDHFCTSP KNGSPVNHRS PSSALSTVLH
1310 1320 1330 1340 1350
SIPSGRKQKK IPAALKEVSA STEDSSMSGY LYRSKSSKKP WKHLWFVIKN
1360 1370 1380 1390 1400
KVLYTYAASE DVAALESQPL LGFTVAEVKD EHLDSKVFHL MHKNTLFYIF
1410 1420
KADDPQSTQK WIEAFQEATI L
Length:1,421
Mass (Da):159,678
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD107EA21B138F597
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008109059.1, XM_008110852.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013020; ENSACAP00000012764; ENSACAG00000012933

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100567784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100567784

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008109059.1, XM_008110852.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012764

Genome annotation databases

EnsembliENSACAT00000013020; ENSACAP00000012764; ENSACAG00000012933
GeneIDi100567784
KEGGiacs:100567784

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55785

Phylogenomic databases

eggNOGiKOG1729, Eukaryota
GeneTreeiENSGT00940000156334
HOGENOMiCLU_004959_0_0_1
InParanoidiG1KN38
OrthoDBi652460at2759
TreeFamiTF343077

Gene expression databases

BgeeiENSACAG00000012933, Expressed in heart and 13 other tissues

Family and domain databases

CDDicd15793, PH1_FGD6, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR037743, FGD6_N_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 2 hits
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KN38_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KN38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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