BHLHE40

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
E-box binding Source: Ensembl
MRF binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RepressorARBA annotation

Molecular function

RepressorARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:BHLHE40Imported
Organismⁱ	Anolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifierⁱ	28377 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
Proteomesⁱ	UP000001646 Componentⁱ: Chromosome 2

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSACAG00000012577, Expressed in skeletal muscle tissue and 14 other tissues

Bgeeⁱ

ENSACAG00000012577, Expressed in skeletal muscle tissue and 14 other tissues

Interactionⁱ

GO - Molecular functionⁱ

MRF binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	28377.ENSACAP00000012353

STRINGⁱ

28377.ENSACAP00000012353

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	58 – 113	BHLHInterPro annotationAdd BLAST		56
Domainⁱ	148 – 181	OrangeInterPro annotationAdd BLAST		34

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 21	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	192 – 222	DisorderedSequence analysisAdd BLAST	31
Regionⁱ	234 – 263	DisorderedSequence analysisAdd BLAST	30

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	103 – 130	Sequence analysisAdd BLAST		28

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1 – 20	Pro-richSequence analysisAdd BLAST	20
Compositional biasⁱ	201 – 216	PolyampholyteSequence analysisAdd BLAST	16
Compositional biasⁱ	234 – 248	PolarSequence analysisAdd BLAST	15

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4304, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158384
HOGENOMⁱ	CLU_049895_0_1_1
InParanoidⁱ	G1KMI4
OMAⁱ	MCAKEVL
Database of Orthologous Groups More...OrthoDBⁱ	629563at2759
TreeFamⁱ	TF330859

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083, HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit
SUPFAMⁱ	SSF47459, SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G1KMI4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERIPSAQPP PPPPPAPPCL GKLATLEGSE MPGLDFAHMY QVYKPRRGLK 
        60         70         80         90        100
RGDDSKETYK LPHRLIEKKR RDRINECIAQ LKDLLPEHLK LTTLGHLEKA 
       110        120        130        140        150
VVLELTLKHV KALTNRIEQQ QQQILALQKG LHADELPPRS LDSSQEVFRS 
       160        170        180        190        200
GFQMCAKEVL QYVAKHENAK ELKSSQLISH LHRVASEVLQ VGIGRKPGDT 
       210        220        230        240        250
APRPTDLKEK SGSLTKTTEA HGKNCVPVIQ RTFAHSSGEQ SGSDTDTDSG 
       260        270        280        290        300
YGGELEKNDS KSDAQYFKKD SDLKYGVQER IGSIKQESED PPAKRTRIEM 
       310        320        330        340        350
SEDEDHFSSD MLGSPSSSFL GPHAHQPPLC LPFYLIPPSA TAYLPMLEKC 
       360        370        380        390        400
WYPASVPILY PSLPTSTAAL SGLMSPEKMS SPLLMPQRLP SPVPSHSPMD 
       410        420
STALLQALKQ MAPLNLETKD

Length:420

Mass (Da):46,493

Last modified:October 19, 2011 - v1

Checksum:ⁱ47B01EEDEDCDECA8

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_003217834.1, XM_003217786.3

RefSeqⁱ

XP_003217834.1, XM_003217786.3

Genome annotation databases

Ensemblⁱ	ENSACAT00000012606; ENSACAP00000012353; ENSACAG00000012577
GeneIDⁱ	100563328
KEGGⁱ	acs:100563328

Protein	Similar proteins		Species	Score	Length	Source
G1KMI4	Basic helix-loop-helix domain-containing protein class B2 (Fragment)		ANOCA		255	UniRef90_G1KMI4
+1

Protein	Similar proteins		Species	Score	Length	Source
G1KMI4	Class E basic helix-loop-helix protein 40		BOVIN		412	UniRef50_Q5EA15
Class E basic helix-loop-helix protein 40		SHEEP		412
Class E basic helix-loop-helix protein 40		wild yak		412
Uncharacterized protein		BOBOX		412
class E basic helix-loop-helix protein 40		BOSIN		412
+150

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_003217834.1, XM_003217786.3

RefSeqⁱ

XP_003217834.1, XM_003217786.3

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	28377.ENSACAP00000012353

STRINGⁱ

28377.ENSACAP00000012353

Genome annotation databases

Ensemblⁱ	ENSACAT00000012606; ENSACAP00000012353; ENSACAG00000012577
GeneIDⁱ	100563328
KEGGⁱ	acs:100563328

Organism-specific databases

CTDⁱ	8553

CTDⁱ

8553

Phylogenomic databases

eggNOGⁱ	KOG4304, Eukaryota
GeneTreeⁱ	ENSGT00940000158384
HOGENOMⁱ	CLU_049895_0_1_1
InParanoidⁱ	G1KMI4
OMAⁱ	MCAKEVL
OrthoDBⁱ	629563at2759
TreeFamⁱ	TF330859

Gene expression databases

Bgeeⁱ	ENSACAG00000012577, Expressed in skeletal muscle tissue and 14 other tissues

Bgeeⁱ

ENSACAG00000012577, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

CDDⁱ	cd00083, HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom
Pfamⁱ	View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit
SUPFAMⁱ	SSF47459, SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G1KMI4_ANOCA
Accessionⁱ	G1KMI4Primary (citable) accession number: G1KMI4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 19, 2011
	Last sequence update:	October 19, 2011
	Last modified:	December 2, 2020
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G1KMI4 (G1KMI4_ANOCA)

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Uncharacterized protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ