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Entry version 54 (12 Aug 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Lipoxygenase homology domains 1

Gene

LOXHD1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lipoxygenase homology domains 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOXHD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000012527, Expressed in brain and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012338

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 159PLATInterPro annotationAdd BLAST118
Domaini171 – 286PLATInterPro annotationAdd BLAST116
Domaini295 – 411PLATInterPro annotationAdd BLAST117
Domaini426 – 541PLATInterPro annotationAdd BLAST116
Domaini554 – 674PLATInterPro annotationAdd BLAST121
Domaini685 – 804PLATInterPro annotationAdd BLAST120
Domaini815 – 935PLATInterPro annotationAdd BLAST121
Domaini964 – 1082PLATInterPro annotationAdd BLAST119
Domaini1095 – 1220PLATInterPro annotationAdd BLAST126
Domaini1249 – 1367PLATInterPro annotationAdd BLAST119
Domaini1421 – 1539PLATInterPro annotationAdd BLAST119
Domaini1552 – 1667PLATInterPro annotationAdd BLAST116
Domaini1680 – 1798PLATInterPro annotationAdd BLAST119
Domaini1811 – 1935PLATInterPro annotationAdd BLAST125
Domaini1952 – 2068PLATInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018830

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000717_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KMH5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRIRTHN

TreeFam database of animal gene trees

More...
TreeFami
TF350466

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.180.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037060, Catalase_core_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01477, PLAT, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00308, LH2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723, SSF49723, 15 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50095, PLAT, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KMH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SKSKDKKKNK NDENFAQMYE QELQDYHSDS AHESEDEYNK KKVYEVVTVT
60 70 80 90 100
GDIRGAGTDA NVFVILFGEF GITPKVHLTS KSCSAFERSK TDVFRVRTNN
110 120 130 140 150
VGTIKKIRIE HDNTSMSPSW YLDRVIVTDM SRPHLRFYFP CNNWLSKDDG
160 170 180 190 200
DGLYVRDLIG SLNPMDVPKV NKYVVRVFTG DMNGSGTDAD VFINIFGQNG
210 220 230 240 250
DTGERRLDND NDNFERGAED KFTLDAPNMG KLRKIAIGHN NKGGSAGWFL
260 270 280 290 300
SKVIIEDIGN KCVYEFPCER WFALDEDDGK IQRDILVGGT EATGIVYNVA
310 320 330 340 350
VVTGDIRGAG TNSKIHIVMH GSKGLKNSGK VFLEGGEFER ARSDLFNVEI
360 370 380 390 400
AALLSPLSRV SIGHDNAGLS CGWYCEKVVA YCPFTGIEQT FPCGKWLDED
410 420 430 440 450
EGDGLFEREL YEMISLPQKK PEKEEYPWSL WIWTSDIKGA GTDAPIFLQI
460 470 480 490 500
YGDKGKSDEM KLDNKSDNFE AGQTDKFMIE LPDFGILYKI RIWHEKRSPF
510 520 530 540 550
AGWHLDKVTL LKTLTKEKYT FHCGRWLDSS EDDFEIGREL TAEGPLVTEV
560 570 580 590 600
MPVIKYRVTV HTGNVSGSGT DAHVFACLIG DQGDTGDRVL QNSVNTVNKF
610 620 630 640 650
EKGSADEFII EAVNLKQVRR VRIGHDGKGG SSGWYLGKVI VREDGQPESE
660 670 680 690 700
AQEFPCYRWL DKNEDDGQII RELVPAGRSS LLENVGYHIS IKTGDVPGAS
710 720 730 740 750
SDSRVFIKLY GEKSDTKKEF LLVSDNDLGN YFERGRIDVF SLDTMDIGKI
760 770 780 790 800
KRLLIGHDNI GFNCGWHLGS VQIIIPVHGK VYNFPCNRWL DKNEYDGRVE
810 820 830 840 850
IEVYPSEIIP IERLINYEVC VATGDVRNAG TNANVFMQIY GELGKTELLI
860 870 880 890 900
LKNRSNNYER GASETFRVDK FSVPAIELGE LTKVRIRQDN TGSNPAWFLE
910 920 930 940 950
RIVIIDTKEE NIYYFPCQRW LAMEEEDGQI ARELVPVDEA FVLKASSDDD
960 970 980 990 1000
SLETLGLEQK AQSTTFTVTV KTGDKKYGGT DSNVFIVLYG MKDDTGTIYL
1010 1020 1030 1040 1050
KASKTNKNKF ERGKIDVFTV ECVDLGDLKK IKMGHDDSGR GKGWFLEWVE
1060 1070 1080 1090 1100
VDAPCLGLCL VFPCGRWLDK SEDDGAIERV LFPADLQTRT YVPFVPYEVT
1110 1120 1130 1140 1150
IYTSDLFAAG TDADVYIVLY GADGVCTQQK PLCQNMRERR MFFERNSVNQ
1160 1170 1180 1190 1200
FIVELEDVGD ILEKIRIGHD GSGINPGWHL KKVEIRRLLR NGKGSEKTTF
1210 1220 1230 1240 1250
PCDKWLASSE DDGEIMRELV PSKVFTEKLM KDGTLKQIEE EIEDSLEIQT
1260 1270 1280 1290 1300
YRITVYTGDI FGAGTDASVF IIIYGDLGDT GEKQLSSSET FTNKFERGQD
1310 1320 1330 1340 1350
DIFTIQAVDL GSVYKIKIRH DNSFPRPDWY LEKVEILNED TDELFLFQCE
1360 1370 1380 1390 1400
RWLSLKKEDN KIERILWEKQ LYIQRKSGIK SDIISWDLTV AFQNADRDRK
1410 1420 1430 1440 1450
SVSALSLKKT SEESAPDGPM IPYHIIITTG SELGSDTDSR VYLIIMGPQK
1460 1470 1480 1490 1500
LRTDRLWLDL PEGQDEFADA SVEKFSVMGR DVEELKKIEI GHDGATPESS
1510 1520 1530 1540 1550
WLLEEITIVV PTKGLMYTFV CKCWLARDMG DGLTSRIFNI LDADSVNIGV
1560 1570 1580 1590 1600
KILYEVTVVT GDISHAGTDA GIFITLSGSN GCSEEMQLDK NGDRFEIGQR
1610 1620 1630 1640 1650
DTFIMEIPDI APLKKMRIRT DGEGCRPDWF LEEIIMKNLT TQDVTTFNYN
1660 1670 1680 1690 1700
DWLSKQWGDN LTLEWEMPAI VDDEVMMEYT TYNVQVKTSD ISGAGTDANV
1710 1720 1730 1740 1750
FLMIFGEYGD TGILPLKQSN RSNKFERDRL DVFDFPDVLC LGDLCKVRVW
1760 1770 1780 1790 1800
HDNKGIAPGW HLEYIDVEDY VLDKIFRFQC DRWLATGEDD KQTIRELACA
1810 1820 1830 1840 1850
NNDILELKEK TSYEILTITS DRDDAETKEN VIVIFEGKNG RSKEFLLENS
1860 1870 1880 1890 1900
SKKRRFLRGA TDVFEFSSKN VGDIAAICVG HCPKDGKKSS IKADVYWHVQ
1910 1920 1930 1940 1950
EIIVTEMELD NKYFFRCNTK IPLRAKRGDQ KVIDCSKVNE SFASKARSLV
1960 1970 1980 1990 2000
PVKYEVIVVT GFEKGSGTDA NVLITIFGLN GDSGKRALKQ KFRNLFERGQ
2010 2020 2030 2040 2050
TDRFYLEILE LGELTKVRIE HDNTGFYPEW LVERVEITNS ATGVTTNFPC
2060 2070
GKWLALNKGD GLLWRALYPR N
Length:2,071
Mass (Da):234,503
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i712FE3F0A693845C
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000012591; ENSACAP00000012338; ENSACAG00000012527

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012338

Genome annotation databases

EnsembliENSACAT00000012591; ENSACAP00000012338; ENSACAG00000012527

Phylogenomic databases

eggNOGiKOG3599, Eukaryota
GeneTreeiENSGT00390000018830
HOGENOMiCLU_000717_0_0_1
InParanoidiG1KMH5
OMAiFRIRTHN
TreeFamiTF350466

Gene expression databases

BgeeiENSACAG00000012527, Expressed in brain and 3 other tissues

Family and domain databases

Gene3Di2.40.180.10, 12 hits
InterProiView protein in InterPro
IPR037060, Catalase_core_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
PfamiView protein in Pfam
PF01477, PLAT, 15 hits
SMARTiView protein in SMART
SM00308, LH2, 13 hits
SUPFAMiSSF49723, SSF49723, 15 hits
PROSITEiView protein in PROSITE
PS50095, PLAT, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KMH5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KMH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: August 12, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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