UniProtKB - G1KMH2 (G1KMH2_ANOCA)
Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
G6PD
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation
Catalytic activityi
- EC:1.1.1.49UniRule annotation
: pentose phosphate pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (G6PD)
- 6-phosphogluconolactonase (pgls)
- 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 238 | SubstratePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
- glucose binding Source: Ensembl
- NADP binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- cellular response to oxidative stress Source: Ensembl
- cholesterol biosynthetic process Source: Ensembl
- erythrocyte maturation Source: Ensembl
- glucose metabolic process Source: UniProtKB-KW
- glutathione metabolic process Source: Ensembl
- negative regulation of protein glutathionylation Source: Ensembl
- pentose biosynthetic process Source: Ensembl
- pentose-phosphate shunt, oxidative branch Source: Ensembl
- ribose phosphate biosynthetic process Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Biological process | Carbohydrate metabolism, Glucose metabolismUniRule annotationARBA annotation |
Ligand | NADPUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00408 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation) |
Gene namesi | Name:G6PDImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centriolar satellite Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- cytoplasmic side of plasma membrane Source: Ensembl
Other locations
- intracellular membrane-bounded organelle Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000012437, Expressed in adrenal gland and 15 other tissues |
Interactioni
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012329 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 243 | G6PD_NInterPro annotationAdd BLAST | 176 | |
Domaini | 245 – 536 | G6PD_CInterPro annotationAdd BLAST | 292 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 39 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0563, Eukaryota |
GeneTreei | ENSGT00530000063435 |
HOGENOMi | CLU_013524_2_3_1 |
InParanoidi | G1KMH2 |
OrthoDBi | 383995at2759 |
TreeFami | TF300584 |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KMH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSRASVRGE RLGERTQGEE AGNNKAANMS RSPRQPQEEL TQADICGMLR
60 70 80 90 100
EELCQGNDFL KSYTHIFIIL GASGDLAKKK IYPTIWWLYR DGLLPDDTYV
110 120 130 140 150
VGYARSQLTV ADIRKQSQPY LKATPEEEQK LNDFFARNSY ISGKYDDQAS
160 170 180 190 200
FERLNAHLNA LHNGDKANRL FYLALPPSVY EHVTANIRHT CMSTVGWNRV
210 220 230 240 250
IVEKPFGKDL ESSNKLSNHI SGLFREDQIY RIDHYLGKEM VQNLMVLRFG
260 270 280 290 300
NRIFGPIWNR DNVACVILTF KEPFGTEGRG GYFDEFGIIR DVMQNHLLQM
310 320 330 340 350
LCLVAMEKPA STNSDDVRDE KVKVLKCISE AKPENVVLGQ YVGDPSGQGE
360 370 380 390 400
AQKGYLDDPT VPAGSTTPTF AAAVLYVDNE RWDGVPFVLR CGKALNERKA
410 420 430 440 450
EVRLQFREVP GDIFQRQCKR NELVIRVQPN EAVYTKMMTK KPGMFFNPEE
460 470 480 490 500
SELDLTYGNR YKGVKLPDAY ERLILDVFCG SQMHFVRSDE LREAWRIFTP
510 520 530 540
LLHKIETEKS KPISYRYGSR GPKEADELMK EVGFQYEGTY RWVNPHKL
Sequence databases
RefSeqi | XP_003216959.2, XM_003216911.2 |
Genome annotation databases
Ensembli | ENSACAT00000012582; ENSACAP00000012329; ENSACAG00000012437 |
GeneIDi | 100555323 |
KEGGi | acs:100555323 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003216959.2, XM_003216911.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012329 |
Genome annotation databases
Ensembli | ENSACAT00000012582; ENSACAP00000012329; ENSACAG00000012437 |
GeneIDi | 100555323 |
KEGGi | acs:100555323 |
Organism-specific databases
CTDi | 2539 |
Phylogenomic databases
eggNOGi | KOG0563, Eukaryota |
GeneTreei | ENSGT00530000063435 |
HOGENOMi | CLU_013524_2_3_1 |
InParanoidi | G1KMH2 |
OrthoDBi | 383995at2759 |
TreeFami | TF300584 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00408 |
Gene expression databases
Bgeei | ENSACAG00000012437, Expressed in adrenal gland and 15 other tissues |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KMH2_ANOCA | |
Accessioni | G1KMH2Primary (citable) accession number: G1KMH2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |