UniProtKB - G1KMD9 (G1KMD9_ANOCA)
Protein
Protein kinase domain-containing protein
Gene
IRAK1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- activation of NF-kappaB-inducing kinase activity Source: Ensembl
- cellular response to lipopolysaccharide Source: GO_Central
- cytokine-mediated signaling pathway Source: GO_Central
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: GO_Central
- intracellular signal transduction Source: GO_Central
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: Ensembl
- positive regulation of MAP kinase activity Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: GO_Central
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of type I interferon production Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of cytokine-mediated signaling pathway Source: Ensembl
- toll-like receptor 2 signaling pathway Source: GO_Central
- toll-like receptor 4 signaling pathway Source: GO_Central
- type I interferon signaling pathway Source: Ensembl
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase domain-containing proteinInterPro annotation |
Gene namesi | Name:IRAK1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000012475, Expressed in lung and 13 other tissues |
ExpressionAtlasi | G1KMD9, baseline |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012253 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 517 | Protein kinaseInterPro annotationAdd BLAST | 300 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 108 – 150 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 657 – 679 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 123 – 150 | PolarSequence analysisAdd BLAST | 28 |
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
InParanoidi | G1KMD9 |
OMAi | TEDQYNF |
TreeFami | TF328924 |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G1KMD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IRQGKGPRGM AGSRSPRFLY ELPASVMCHF YEIMDALGRE EWQRFASRIV
60 70 80 90 100
RDQVELRLYE RMEAPTSKVM WAWMNRNARV SDLLQILDDL QLYRAHNVIA
110 120 130 140 150
SWNPPSRPVE SRAVPCPQSH RQGLGGASHS PPSTTASTSP SSAPPPVVAQ
160 170 180 190 200
EHSQSGLTRV YFPLEIKNPL PTAASAAWTR TACGHLPQSP TSRGLSSLSL
210 220 230 240 250
TCPFEWRLEE LRQATSDFSE NLKIGEGGFG CVYQARLRNT IYAVKRLKEE
260 270 280 290 300
AELDWSVIKN SFVTEVEKLY RFRHPNIVEL AGYCAEQGNF CLVYVFLPKG
310 320 330 340 350
SLDDHLHRQV GPCLTWSQRL HVAVGTSRAI QFLHSDSPSL IHGDVKSSNI
360 370 380 390 400
LLDAALNPRL ADFGLARFSR RPKQGTMSSS LGRTQTVQGT LAYLPPEYVR
410 420 430 440 450
TGTLSTAIDV FSFGVVLLEL LTGRRPMEVD SCGHSKYLKD LLSEEEEAQH
460 470 480 490 500
TPTTMTSSSS QAAQLGTSLY QKHMDLQAGP CPELLGIMIG RLACQCLHPR
510 520 530 540 550
AKRRPPMAEV YQELERLQLS LYGESSDSLL PSRQLHTTQE NLFPARHLNQ
560 570 580 590 600
PQEIDERQVA GFDLSLEVWD MTQGLFPSQF ALPRISSTLS VTSCLQYLYD
610 620 630 640 650
EQMYMAFQKG SSLGHHSLLF NASAPQIIIN PARRRMMERL ALYRDGMLDS
660 670
LAVLASAPSV SELSPEPSRE PEESDEFES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GCA5 | R4GCA5_ANOCA | Protein kinase domain-containing pr... | IRAK1 | 634 | Annotation score: |
Genome annotation databases
Ensembli | ENSACAT00000012504; ENSACAP00000012253; ENSACAG00000012475 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012253 |
Genome annotation databases
Ensembli | ENSACAT00000012504; ENSACAP00000012253; ENSACAG00000012475 |
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
InParanoidi | G1KMD9 |
OMAi | TEDQYNF |
TreeFami | TF328924 |
Gene expression databases
Bgeei | ENSACAG00000012475, Expressed in lung and 13 other tissues |
ExpressionAtlasi | G1KMD9, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KMD9_ANOCA | |
Accessioni | G1KMD9Primary (citable) accession number: G1KMD9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | February 10, 2021 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |