UniProtKB - G1KM87 (G1KM87_ANOCA)
Protein
Decorin
Gene
DCN
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
May affect the rate of fibrils formation.UniRule annotation
GO - Molecular functioni
- collagen binding Source: InterPro
- extracellular matrix binding Source: Ensembl
- extracellular matrix structural constituent conferring compression resistance Source: InterPro
- glycosaminoglycan binding Source: Ensembl
GO - Biological processi
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of endothelial cell migration Source: Ensembl
- negative regulation of vascular endothelial growth factor signaling pathway Source: Ensembl
- peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
- positive regulation of macroautophagy Source: Ensembl
- positive regulation of mitochondrial depolarization Source: Ensembl
- positive regulation of mitochondrial fission Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: DecorinUniRule annotation |
Gene namesi | Name:DCNImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular matrix UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
Extracellular matrixUniRule annotationARBA annotation, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | UniRule annotationAdd BLAST | 16 | |
ChainiPRO_5011020416 | 17 – 357 | DecorinUniRule annotationAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 52 ↔ 58 | UniRule annotation | ||
Disulfide bondi | 56 ↔ 65 | UniRule annotation | ||
Disulfide bondi | 311 ↔ 344 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, Glycoprotein, ProteoglycanARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000012367, Expressed in lung and 14 other tissues |
Interactioni
Subunit structurei
Binds to type I and type II collagen, fibronectin and TGF-beta.
Forms a ternary complex with MFAP2 and ELN.
UniRule annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000012156 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 83 | LRRNTInterPro annotationAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 146 – 166 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.UniRule annotationARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalUniRule annotationPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158382 |
HOGENOMi | CLU_000288_186_0_1 |
InParanoidi | G1KM87 |
OMAi | MCPFRCQ |
OrthoDBi | 826997at2759 |
TreeFami | TF334562 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR028549, Decorin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR016352, SLRP_I_decor/aspor/byglycan |
PANTHERi | PTHR45712:SF14, PTHR45712:SF14, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF01462, LRRNT, 1 hit |
PIRSFi | PIRSF002490, SLRP_I, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 7 hits |
i Sequence
Sequence statusi: Complete.
G1KM87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLAVFFLLL LPLCLAKPFH QRGLFDFMLE DEAGSGTPEP TVPPGYPGMA
60 70 80 90 100
VCPFRCQCHL RVVQCSDLGL TQVPKDLPPD TTLLDLQNNK ITEIKDGDFK
110 120 130 140 150
NLKELHALIL VNNKISKISP RAFAPLKKLE RLYLSKNNLK ELPENMPKSL
160 170 180 190 200
QELRAHENDI NKLRKAVFSG LNNMIVVELG TNPIKSSGIE NGAFQGMKRL
210 220 230 240 250
SYIRISDTNI TNIPKGLPSS LTELHLDGNK INKVDADSLN GLDNLAKLGL
260 270 280 290 300
SFNDIASVDN GTLTNVPHLR ELHLDNNDLS KVPPGLGEHK YIQVVYLHNN
310 320 330 340 350
KIAAVGPNDF CPPGYNTKKA SYSGVSLFSN PVQYWEIQPS SFRCIYERSV
IQLGNYK
Sequence databases
RefSeqi | XP_003221092.1, XM_003221044.3 |
Genome annotation databases
Ensembli | ENSACAT00000012403; ENSACAP00000012156; ENSACAG00000012367 |
GeneIDi | 100561696 |
KEGGi | acs:100561696 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003221092.1, XM_003221044.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012156 |
Genome annotation databases
Ensembli | ENSACAT00000012403; ENSACAP00000012156; ENSACAG00000012367 |
GeneIDi | 100561696 |
KEGGi | acs:100561696 |
Organism-specific databases
CTDi | 1634 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158382 |
HOGENOMi | CLU_000288_186_0_1 |
InParanoidi | G1KM87 |
OMAi | MCPFRCQ |
OrthoDBi | 826997at2759 |
TreeFami | TF334562 |
Gene expression databases
Bgeei | ENSACAG00000012367, Expressed in lung and 14 other tissues |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR028549, Decorin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR016352, SLRP_I_decor/aspor/byglycan |
PANTHERi | PTHR45712:SF14, PTHR45712:SF14, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF01462, LRRNT, 1 hit |
PIRSFi | PIRSF002490, SLRP_I, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KM87_ANOCA | |
Accessioni | G1KM87Primary (citable) accession number: G1KM87 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |