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Entry version 66 (29 Sep 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

CECR2 histone acetyl-lysine reader

Gene

CECR2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CECR2 histone acetyl-lysine readerImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CECR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000012297, Expressed in embryonic post-anal tail and 9 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012062

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini457 – 527BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni562 – 662DisorderedSequence analysisAdd BLAST101
Regioni677 – 701DisorderedSequence analysisAdd BLAST25
Regioni855 – 908DisorderedSequence analysisAdd BLAST54
Regioni923 – 942DisorderedSequence analysisAdd BLAST20
Regioni956 – 991DisorderedSequence analysisAdd BLAST36
Regioni1021 – 1050DisorderedSequence analysisAdd BLAST30
Regioni1068 – 1088DisorderedSequence analysisAdd BLAST21
Regioni1170 – 1189DisorderedSequence analysisAdd BLAST20
Regioni1230 – 1266DisorderedSequence analysisAdd BLAST37
Regioni1281 – 1333DisorderedSequence analysisAdd BLAST53
Regioni1453 – 1484DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili357 – 404Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi616 – 638Polar residuesSequence analysisAdd BLAST23
Compositional biasi877 – 891Polar residuesSequence analysisAdd BLAST15
Compositional biasi928 – 942Pro residuesSequence analysisAdd BLAST15
Compositional biasi956 – 977Polar residuesSequence analysisAdd BLAST22
Compositional biasi1022 – 1036Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1171 – 1189Polar residuesSequence analysisAdd BLAST19
Compositional biasi1238 – 1252Pro residuesSequence analysisAdd BLAST15
Compositional biasi1281 – 1295Polar residuesSequence analysisAdd BLAST15
Compositional biasi1300 – 1327Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1457 – 1484Pro residuesSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

BromodomainPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1472, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160360

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006327_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KM42

Database of Orthologous Groups

More...
OrthoDBi
103411at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324727

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR029614, CECR2

The PANTHER Classification System

More...
PANTHERi
PTHR47092, PTHR47092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1KM42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPEEDGGCG GASAAAAAVI STSSAGSGGP EGTLTATGLL SELRSWWEVP
60 70 80 90 100
AIAHFCSLFR TAFRLPDFEI EELEAALYSD DVEFISDLIA CLLQGCYQRS
110 120 130 140 150
DITSQTFHGY LEDIINYRWE LEEGKPNPLR ETAFQELPLR TRVEILHRLC
160 170 180 190 200
DYRLDADDVF DLLKGLDADS LRVEPLGEDS NGALYWYFYG TRMYKEEPVK
210 220 230 240 250
SNGELSSNRG CEAQTDTPMV PEKIVKRRGR PPKRKKLLEE NILRKKTEEN
260 270 280 290 300
VPVHDSQLRN GSKGPGHGTW WLLCQTEEEW RQVTESFRER TSLRERQLYK
310 320 330 340 350
LLSEDFLPEI CNMIAQKEKR LQQMEYSPRW MSDHQHIKPV RQEVTPMMFG
360 370 380 390 400
RTEKQKRKEE EEERQILLAV QKREQEQMLK EERRREMEEK VKAVEERAKR
410 420 430 440 450
RKLREERAWL LAQGKELPPE LSHLDPSSPT RDERKTKDLF ELDDEFTAMY
460 470 480 490 500
KVLDVVKAHK DSWPFLEPVD ESYAPNYYQI IKAPMDICSM EKKLNAGQYY
510 520 530 540 550
TKEEFMGDMK IMFRNCLKYN GENSEYTKMA YNLERCFHRA MMKHFPGEDG
560 570 580 590 600
DTDDEFWIRE DGKREKRSRR TIRSSTGNVW TRSRESEGSG KKQQHIQNGG
610 620 630 640 650
KLPPHKAKHR VSASSSPPFL LFTEDPSSSS SQPSGEAVSP NGRGFLRSHH
660 670 680 690 700
YGGMPSRISH PGQVRAAVPG TFSVLRVSNS TKPYGSPRVP EPHPGDPGHQ
710 720 730 740 750
QQHFAIQPTG GLNDPRGHQL TVSEKQVCAG PMHISTIGPP GSLQFGRMNG
760 770 780 790 800
PPSEASMYSP SQFQQGFISP RHNGPPLRQP ETSEPHPGHM YRPYKYFNHT
810 820 830 840 850
HPAVWNGSHD AANQMALGID KKSAMGPCSP LPPHALSHMM EPRALRPPLP
860 870 880 890 900
SNQWTEQANF LPHGAPPSGY IRQPGKSPGQ RMQQQLPPSL FGPAPQMQRG
910 920 930 940 950
AQGGDSMMDS PEMIAMQQLS SRVCPPGVPY HPRQPPPPHL PGPFPQLAHV
960 970 980 990 1000
ATTNVQHPKP ILGNGNSQDT TQTAEPEDNG VEPPPGVEKK TQCIGLSEGT
1010 1020 1030 1040 1050
YPKLLPHSKP LLQMNYSRQN LKQEGEGDDS ETKNDPKATQ SKSMWPSESS
1060 1070 1080 1090 1100
YTSALAQGCV RDVVTATERG PVPENGAVSE GPSSGAEGKT VATNIMDNPR
1110 1120 1130 1140 1150
CTMGKNHLET TVPCMGQGTS VPVGIDGSPV GGSSGQFAPF YMPNVEYPNS
1160 1170 1180 1190 1200
ATHYHINPGL QGFRPMVGGK STPMSHSQHF SARGLQPNNN NHGVFPRYRP
1210 1220 1230 1240 1250
HQGMPYPYQT QPSPSYHHYQ QPPYYTCPQG YSEWQRPFPP QSNPPGHPHT
1260 1270 1280 1290 1300
QSPLARPPFS DRGTTDMQGC EVLSTALASP NLIDTTATKD IPNSGQELPS
1310 1320 1330 1340 1350
EAEKPEESQE RPESPKEFLD LDNHNAATKR QRSVATGEYL YGSPPPPINS
1360 1370 1380 1390 1400
SGLGFGPSAF PHHGVMLQTG PSYSSRHPAS HFQPRAYGSS VNTCLSSHPP
1410 1420 1430 1440 1450
TSHPNGLVHE GSLYRCQEDN VGHFQALVME QTGRGGGMGG LSTDLYRTAG
1460 1470 1480
MQMHHPPVPF PKVPAPARDE LPPQKPPVLP LDQS
Length:1,484
Mass (Da):165,494
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF55B651DA1C0CF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SSL0A0A803SSL0_ANOCA
CECR2 histone acetyl-lysine reader
CECR2
1,505Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008108682.1, XM_008110475.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000012307; ENSACAP00000012062; ENSACAG00000012297

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100554039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100554039

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008108682.1, XM_008110475.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012062

Genome annotation databases

EnsembliENSACAT00000012307; ENSACAP00000012062; ENSACAG00000012297
GeneIDi100554039
KEGGiacs:100554039

Phylogenomic databases

eggNOGiKOG1472, Eukaryota
GeneTreeiENSGT00940000160360
HOGENOMiCLU_006327_0_0_1
InParanoidiG1KM42
OrthoDBi103411at2759
TreeFamiTF324727

Gene expression databases

BgeeiENSACAG00000012297, Expressed in embryonic post-anal tail and 9 other tissues

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR029614, CECR2
PANTHERiPTHR47092, PTHR47092, 1 hit
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KM42_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KM42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: September 29, 2021
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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