UniProtKB - G1KLY3 (G1KLY3_ANOCA)
Protein
Exo-alpha-sialidase
Gene
NEU1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.ARBA annotation EC:3.2.1.18
GO - Molecular functioni
- exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
- exo-alpha-sialidase activity Source: GO_Central
GO - Biological processi
- ganglioside catabolic process Source: GO_Central
- oligosaccharide catabolic process Source: GO_Central
Keywordsi
Biological process | Lipid degradationARBA annotation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:NEU1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Lysosome
- lysosome Source: GO_Central
Other locations
- cell junction Source: Ensembl
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000012147, Expressed in kidney and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 370 | SialidaseInterPro annotationAdd BLAST | 289 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 33 family.ARBA annotation
Phylogenomic databases
eggNOGi | ENOG502QSIT, Eukaryota |
GeneTreei | ENSGT00950000182944 |
HOGENOMi | CLU_024620_3_0_1 |
InParanoidi | G1KLY3 |
OrthoDBi | 652179at2759 |
TreeFami | TF331063 |
Family and domain databases
InterProi | View protein in InterPro IPR011040, Sialidase IPR026856, Sialidase_fam IPR036278, Sialidase_sf |
PANTHERi | PTHR10628, PTHR10628, 1 hit |
Pfami | View protein in Pfam PF13088, BNR_2, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KLY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAGRDPKRR SETWNSLVLS RRGFCLGGLL VLGLCCWDVL GVATPDQVKP
60 70 80 90 100
IIAMEQLLWV SGSVIGEVNT FRIPLIAATP RGTLLAFSEA RKHSSSDIGA
110 120 130 140 150
KFIALRRSQD KGATWSPTSF IVDDGSLADG LNLGAVAVDW EKDIVFLVYT
160 170 180 190 200
LCAHYHQCTT ASTMIIRSRD DGVTWSVPRN LSEDIGTTMF APGPGYGIQK
210 220 230 240 250
RYAPKKGRLI VCGHGTLTRD GISCLLSDDH GLTWRYGRQP LHGIPYGETK
260 270 280 290 300
LLSDFNPDEC QPYELPDGSV VINARNQNFY HCSCRIVIRS YDACETLPLE
310 320 330 340 350
NVTFDMTLVD PAVAAGALVK SGLVFFSNPA HERERINMTL RWSFTNGSSW
360 370 380 390 400
WKEPLQIWSG ASGYSSMTAL DGSAPEDAQS LFIIYEKGRL TSTDSVSVAK
ISIDGKL
Sequence databases
RefSeqi | XP_003218036.1, XM_003217988.3 |
Genome annotation databases
Ensembli | ENSACAT00000012192; ENSACAP00000011948; ENSACAG00000012147 |
GeneIDi | 100553632 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003218036.1, XM_003217988.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011948 |
Genome annotation databases
Ensembli | ENSACAT00000012192; ENSACAP00000011948; ENSACAG00000012147 |
GeneIDi | 100553632 |
Organism-specific databases
CTDi | 4758 |
Phylogenomic databases
eggNOGi | ENOG502QSIT, Eukaryota |
GeneTreei | ENSGT00950000182944 |
HOGENOMi | CLU_024620_3_0_1 |
InParanoidi | G1KLY3 |
OrthoDBi | 652179at2759 |
TreeFami | TF331063 |
Gene expression databases
Bgeei | ENSACAG00000012147, Expressed in kidney and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011040, Sialidase IPR026856, Sialidase_fam IPR036278, Sialidase_sf |
PANTHERi | PTHR10628, PTHR10628, 1 hit |
Pfami | View protein in Pfam PF13088, BNR_2, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KLY3_ANOCA | |
Accessioni | G1KLY3Primary (citable) accession number: G1KLY3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 55 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |