UniProtKB - G1KLV2 (G1KLV2_ANOCA)
Protein
Decapping nuclease
Gene
DXO
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.UniRule annotation
Catalytic activityi
- a 5'-end NAD+-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H+ + NAD+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
Mg2+UniRule annotationNote: Binds 2 magnesium ions.UniRule annotation
GO - Molecular functioni
- exonuclease activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA pyrophosphohydrolase activity Source: GO_Central
GO - Biological processi
- NAD-cap decapping Source: GO_Central
- nuclear-transcribed mRNA catabolic process Source: GO_Central
- nucleic acid phosphodiester bond hydrolysis Source: GO_Central
Keywordsi
Molecular function | ExonucleaseARBA annotation, Hydrolase, Nuclease, RNA-bindingUniRule annotation |
Ligand | MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DXOImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000012071, Expressed in skeletal muscle tissue and 15 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 252 – 317 | RAI1InterPro annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 35 | PolyampholyteSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1982, Eukaryota |
GeneTreei | ENSGT00390000006425 |
HOGENOMi | CLU_024877_1_2_1 |
InParanoidi | G1KLV2 |
OrthoDBi | 1034620at2759 |
TreeFami | TF322812 |
Family and domain databases
InterProi | View protein in InterPro IPR013961, RAI1 IPR039039, RAI1-like_fam |
PANTHERi | PTHR12395, PTHR12395, 1 hit |
Pfami | View protein in Pfam PF08652, RAI1, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KLV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSEQLSIKM SLNPETCERK EDRDVPKDCS AKRQRTDPKV PPTLPAGPSR
60 70 80 90 100
YDGPFPFYRR PSEMGRFSLD GQRCYHGDAR KLRYYAPPPI EGPSPGFDLR
110 120 130 140 150
DGYHDRYVRR DESIREGLEH LLRWVSQNRK LLQSEDKGRP LNADFITWRG
160 170 180 190 200
HLTKVLTTPY ETQEGWLLAV SLFRGTLYIS EVETEAARKQ REERSELLKE
210 220 230 240 250
LTYMGYKFEQ YMCADTPDGT PDPTGVVNTN EGFCTVIRTR LGTHSLLFSG
260 270 280 290 300
EVDCTDPRSP WPDPPSCYVE LKTSKVMHSP AQRRSFYRHK MIKWWAQSFL
310 320 330 340 350
PGVSRIVAGY RGPDGTIVGL ETFETMKIFQ LIREDPGCWK PAVCMNFCAA
360 370 380 390 400
FLAFVKKVVT EDNSKLVHLF AWEPGQPVSF TVHRDSSYTF LPDWYVDALS
410
TEKPPTPRIP D
Sequence databases
RefSeqi | XP_003218044.1, XM_003217996.3 |
Genome annotation databases
Ensembli | ENSACAT00000012092; ENSACAP00000011848; ENSACAG00000012071 |
GeneIDi | 100555398 |
KEGGi | acs:100555398 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003218044.1, XM_003217996.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011848 |
Genome annotation databases
Ensembli | ENSACAT00000012092; ENSACAP00000011848; ENSACAG00000012071 |
GeneIDi | 100555398 |
KEGGi | acs:100555398 |
Organism-specific databases
CTDi | 1797 |
Phylogenomic databases
eggNOGi | KOG1982, Eukaryota |
GeneTreei | ENSGT00390000006425 |
HOGENOMi | CLU_024877_1_2_1 |
InParanoidi | G1KLV2 |
OrthoDBi | 1034620at2759 |
TreeFami | TF322812 |
Gene expression databases
Bgeei | ENSACAG00000012071, Expressed in skeletal muscle tissue and 15 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013961, RAI1 IPR039039, RAI1-like_fam |
PANTHERi | PTHR12395, PTHR12395, 1 hit |
Pfami | View protein in Pfam PF08652, RAI1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KLV2_ANOCA | |
Accessioni | G1KLV2Primary (citable) accession number: G1KLV2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |