UniProtKB - G1KLT6 (G1KLT6_ANOCA)
Protein
Katanin p60 ATPase-containing subunit A-like 2
Gene
KATNAL2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.UniRule annotation
Catalytic activityi
- n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.UniRule annotation EC:5.6.1.1
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 296 – 303 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- isomerase activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB-UniRule
- microtubule-severing ATPase activity Source: GO_Central
GO - Biological processi
- cytoplasmic microtubule organization Source: GO_Central
Keywordsi
Molecular function | IsomeraseUniRule annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:5.6.1.1UniRule annotation)Short name: Katanin p60 subunit A-like 2UniRule annotation Alternative name(s): p60 katanin-like 2UniRule annotation |
Gene namesi | Name:KATNAL2UniRule annotationImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
- spindle UniRule annotation
- spindle pole UniRule annotation
Other locations
- Cytoplasm UniRule annotation
Note: Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.UniRule annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
- spindle pole Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000012057, Expressed in embryonic post-anal tail and 12 other tissues |
Interactioni
GO - Molecular functioni
- microtubule binding Source: UniProtKB-UniRule
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011813 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 57 | LisHInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 157 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 106 – 143 | PolarSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
HOGENOMi | CLU_000688_21_1_1 |
InParanoidi | G1KLT6 |
OMAi | MKTQGKY |
OrthoDBi | 787710at2759 |
TreeFami | TF329610 |
Family and domain databases
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KLT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELTYHALKK THEVREAEEM RIEARRKNLL ILILHYLTEE GYVDTANTLE
60 70 80 90 100
QETKMNLRRF EVCDNVDLET IMMEYESYYY VKFQKYPKIT KKTLDSTDNK
110 120 130 140 150
SRSGGKLKRA GSSTYRNLPK ISQHQTTQRP TSKANASRTA DSKCCSKESP
160 170 180 190 200
RQDSEDALTR MSSDFGLNVS AIHKGGGGEG THPRRGQIID FRGMIHDAIK
210 220 230 240 250
GASSEIALHS LNCNPDPSER LLKPLGAFGG MSAEMRELAT VVSRDIYLHN
260 270 280 290 300
PNVKWSDIIG LDAAKRLVKE AVVYPIRYPQ LFTGILSPWK GLLLYGPPGT
310 320 330 340 350
GKTLLAKAVA TECNTTFFNI SASTIVSKWR GDSEKLVRVL FELARYHAPS
360 370 380 390 400
TIFLDELESV MSQRGTVPGG EHEGSRRMKT ELLVQMDGLA RSDDLVFVLA
410 420 430 440 450
ASNLPWELDC AMLRRLEKRI LVDLPSQEAR QAMIQHWLPP VSNSGGVTLR
460 470 480 490 500
TELDYALLSQ EMDGYSGSDI KLGCKEAAMR PVRKIFSALE NHQPDTGSLP
510 520 530 540
VIQLDTVTTK DFLEVLMHTK PSAKNLTQKY TSWQREFESV
Sequence databases
RefSeqi | XP_008101682.1, XM_008103475.2 |
Genome annotation databases
Ensembli | ENSACAT00000012057; ENSACAP00000011813; ENSACAG00000012057 |
GeneIDi | 100565087 |
KEGGi | acs:100565087 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008101682.1, XM_008103475.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011813 |
Genome annotation databases
Ensembli | ENSACAT00000012057; ENSACAP00000011813; ENSACAG00000012057 |
GeneIDi | 100565087 |
KEGGi | acs:100565087 |
Organism-specific databases
CTDi | 83473 |
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
HOGENOMi | CLU_000688_21_1_1 |
InParanoidi | G1KLT6 |
OMAi | MKTQGKY |
OrthoDBi | 787710at2759 |
TreeFami | TF329610 |
Gene expression databases
Bgeei | ENSACAG00000012057, Expressed in embryonic post-anal tail and 12 other tissues |
Family and domain databases
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KLT6_ANOCA | |
Accessioni | G1KLT6Primary (citable) accession number: G1KLT6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |