UniProtKB - G1KLN0 (G1KLN0_ANOCA)
Protein
MICOS complex subunit MIC60
Gene
IMMT
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation
GO - Biological processi
- cristae formation Source: GO_Central
- mitochondrial calcium ion homeostasis Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: MICOS complex subunit MIC60UniRule annotationAlternative name(s): MitofilinUniRule annotation |
Gene namesi | Name:IMMTImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotationARBA annotation; Single-pass membrane protein UniRule annotationARBA annotation
Mitochondrion
- MICOS complex Source: GO_Central
- mitochondrial intermembrane space Source: Ensembl
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011776, Expressed in heart and 14 other tissues |
Interactioni
Subunit structurei
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
UniRule annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000011667 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 145 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 157 – 186 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 289 – 316 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 399 – 433 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 501 – 531 | Sequence analysisAdd BLAST | 31 | |
Coiled coili | 550 – 570 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 170 – 186 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, TransmembraneUniRule annotationPhylogenomic databases
eggNOGi | KOG1854, Eukaryota |
GeneTreei | ENSGT00390000002313 |
HOGENOMi | CLU_021851_0_0_1 |
InParanoidi | G1KLN0 |
OMAi | LLMIPPG |
OrthoDBi | 1073064at2759 |
TreeFami | TF312832 |
Family and domain databases
InterProi | View protein in InterPro IPR019133, Mt-IM_prot_Mitofilin |
PANTHERi | PTHR15415, PTHR15415, 1 hit |
Pfami | View protein in Pfam PF09731, Mitofilin, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KLN0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRACQRAGS TAAQNCLCGK SSLRPLRLYR GYSTSGESGV SAGKIIGASV
60 70 80 90 100
LFVGGGVGGT ILYANYDPRF RENVEKTIPY SNNVFEMVLG PPPYSIPTPK
110 120 130 140 150
KPIQPGPLKI SSVAEVMKES KQPAVKSQKS KTEVTSAASE DKEAHSEVAQ
160 170 180 190 200
IISATGEAVS VPAPGIQEKD QSKSRAHPEE KHKPPVLGKE HMPVVKERPP
210 220 230 240 250
EEVAARLAQQ DKEEQAKISA LASTLESALN NTARVTLQAI TLQEAAVQAV
260 270 280 290 300
NLHAQKLKDA MDESEVPSDR KATQWRTLEE ALKDRRKAVD EAADVLLKAK
310 320 330 340 350
EELEKMKGVI DDAKKSLISG AKPHILAAEE SLHHMIVDLD SVVKKVQAAQ
360 370 380 390 400
SEAKIVTQYH ELVAKARDEF QKELDSITPE VQPGWKGLKI TDLAGKLTAD
410 420 430 440 450
DLNSLIAHAH RRIDQLNKEL VELRVREKQH IEVALEKQKL EDKKAFESAV
460 470 480 490 500
AKALEHHKNE IQIEQEKKVE EAQAVMESEM RTQLRRQAAA HSDHLRDVLR
510 520 530 540 550
IQEQELKLEF EQGLSEKLSE QEMQYKRLSQ EQLDNFTLDI NTAYARLRGI
560 570 580 590 600
EQAVESHSDA EEEARKAHQL WLSVEALKQS MKTASGDSPT EPLEGAVEAI
610 620 630 640 650
QASCSDNTFT KALTAALPKE SLNRGVYTEE TLRARFHTVQ KLAKRVALID
660 670 680 690 700
ETRNSLYQYF LSYLQSVLLF HPQQLKPPAE LGPEDLDTFK LLSYASYCIE
710 720 730 740 750
HGDLELAAKF VNQLRGESRR VSQDWLNEAR MTLETKQVVE ILTAYASAVG
LGTTQVD
Sequence databases
RefSeqi | XP_003222422.1, XM_003222374.3 |
Genome annotation databases
Ensembli | ENSACAT00000011907; ENSACAP00000011667; ENSACAG00000011776 |
GeneIDi | 100563025 |
KEGGi | acs:100563025 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003222422.1, XM_003222374.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011667 |
Genome annotation databases
Ensembli | ENSACAT00000011907; ENSACAP00000011667; ENSACAG00000011776 |
GeneIDi | 100563025 |
KEGGi | acs:100563025 |
Organism-specific databases
CTDi | 10989 |
Phylogenomic databases
eggNOGi | KOG1854, Eukaryota |
GeneTreei | ENSGT00390000002313 |
HOGENOMi | CLU_021851_0_0_1 |
InParanoidi | G1KLN0 |
OMAi | LLMIPPG |
OrthoDBi | 1073064at2759 |
TreeFami | TF312832 |
Gene expression databases
Bgeei | ENSACAG00000011776, Expressed in heart and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR019133, Mt-IM_prot_Mitofilin |
PANTHERi | PTHR15415, PTHR15415, 1 hit |
Pfami | View protein in Pfam PF09731, Mitofilin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KLN0_ANOCA | |
Accessioni | G1KLN0Primary (citable) accession number: G1KLN0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 55 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |