UniProtKB - G1KL86 (G1KL86_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
SOCS6
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of signal transduction Source: UniProtKB-KW
- negative regulation of T cell activation Source: Ensembl
- phosphatidylinositol phosphorylation Source: GO_Central
- proteasomal protein catabolic process Source: Ensembl
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Signal transduction inhibitorARBA annotation |
Biological process | Growth regulationARBA annotation, Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:SOCS6Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- immunological synapse Source: Ensembl
Other locations
- phosphatidylinositol 3-kinase complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000011568, Expressed in embryo and 15 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 382 – 489 | SH2InterPro annotationAdd BLAST | 108 | |
Domaini | 484 – 533 | SOCS boxInterPro annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 79 – 143 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 86 – 142 | PolarSequence analysisAdd BLAST | 57 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000154847 |
HOGENOMi | CLU_038160_0_0_1 |
InParanoidi | G1KL86 |
OMAi | HSFCLDS |
OrthoDBi | 924518at2759 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10387, SH2_SOCS6, 1 hit cd03740, SOCS_SOCS6, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028421, SOCS6 IPR035865, SOCS6_SH2 IPR037345, SOCS6_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF17, PTHR10155:SF17, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KL86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKISLKTIR KSFNLNKSKD ESDFVVVTQP SLNDFGKDDS LFGGCYGKDL
60 70 80 90 100
ASCDINSEDE KSGKNRSKSE SLMGTLKRRL SAKQKQKGSK GSTPSVSSAD
110 120 130 140 150
DDTFSSSSAP ITFKDARTQR PLRSTSLRNH HYSPTPWPLR PTNSEETCIK
160 170 180 190 200
MEVKVKALVH SSNPSPALNG VRKDFHDLQP DGMFQEQNNT LKSTESQNGD
210 220 230 240 250
LHLHIDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY CLDSSSPMEV
260 270 280 290 300
STVSSQLGGG AFHEEEAPVS QDVVVAPDIF VDQSGLLIGT TGVMLQSPRV
310 320 330 340 350
NHSDVPPLSP LLPPIQNNQI QRNFNGLNGT DVHVAESMHC HLNFDPNSAP
360 370 380 390 400
GVGRVYDSVQ SSGPMVVTSL TEELKKLAKQ GWYWGPITRW EAEGKLANVP
410 420 430 440 450
DGSFLVRDSS DDRYLLSLSF RSHGKTLHTR IEHSNGRFSF YEQPDVEGHT
460 470 480 490 500
SIVDLIEHSI RDSENGAFCY SRSRLPGSTT YPVRLTNPVS RFMQVRSLQY
510 520 530
LCRFVIRQYT RIDLIQKLPL PNKMKDYLQE KHY
Sequence databases
RefSeqi | XP_003219773.1, XM_003219725.3 XP_008106936.1, XM_008108729.2 |
Genome annotation databases
Ensembli | ENSACAT00000011543; ENSACAP00000011306; ENSACAG00000011568 |
GeneIDi | 100557492 |
KEGGi | acs:100557492 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003219773.1, XM_003219725.3 XP_008106936.1, XM_008108729.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011306 |
Genome annotation databases
Ensembli | ENSACAT00000011543; ENSACAP00000011306; ENSACAG00000011568 |
GeneIDi | 100557492 |
KEGGi | acs:100557492 |
Organism-specific databases
CTDi | 9306 |
Phylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000154847 |
HOGENOMi | CLU_038160_0_0_1 |
InParanoidi | G1KL86 |
OMAi | HSFCLDS |
OrthoDBi | 924518at2759 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Gene expression databases
Bgeei | ENSACAG00000011568, Expressed in embryo and 15 other tissues |
Family and domain databases
CDDi | cd10387, SH2_SOCS6, 1 hit cd03740, SOCS_SOCS6, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028421, SOCS6 IPR035865, SOCS6_SH2 IPR037345, SOCS6_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF17, PTHR10155:SF17, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KL86_ANOCA | |
Accessioni | G1KL86Primary (citable) accession number: G1KL86 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |