UniProtKB - G1KKW5 (G1KKW5_ANOCA)
Protein
Eukaryotic translation initiation factor 3 subunit H
Gene
EIF3H
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation
GO - Molecular functioni
- isopeptidase activity Source: InterPro
- metallopeptidase activity Source: GO_Central
- translation initiation factor activity Source: UniProtKB-UniRule
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Keywordsi
Molecular function | Initiation factorUniRule annotationARBA annotation |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit HUniRule annotationShort name: eIF3hUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 3UniRule annotation eIF-3 gammaUniRule annotation eIF3 p40 subunitUniRule annotation |
Gene namesi | Name:EIF3HUniRule annotationImported Synonyms:EIF3S3UniRule annotation |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Cytoplasm UniRule annotation
Cytosol
- cytosol Source: GO_Central
Other locations
- eukaryotic 43S preinitiation complex Source: GO_Central
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: GO_Central
- eukaryotic translation initiation factor 3 complex, eIF3m Source: Ensembl
- polysomal ribosome Source: GO_Central
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011074, Expressed in forelimb bud and 14 other tissues |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
UniRule annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000010921 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 129 | MPNInterPro annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 224 – 271 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 224 – 246 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the eIF-3 subunit H family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1560, Eukaryota |
GeneTreei | ENSGT00730000111042 |
HOGENOMi | CLU_044094_0_0_1 |
InParanoidi | G1KKW5 |
OMAi | KFNRYQQ |
TreeFami | TF101504 |
Family and domain databases
CDDi | cd08065, MPN_eIF3h, 1 hit |
HAMAPi | MF_03007, eIF3h, 1 hit |
InterProi | View protein in InterPro IPR027524, eIF3h IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF3, PTHR10410:SF3, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KKW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VVLKIIKHYQ EEGQGNEVVQ GVLLGLVVDD RLEITNCFPF PQHTEDDADF
60 70 80 90 100
DEVQYQMEMM RSLRHVNIDH LHVGWYQSTY YGSFVTRALL DSQFSYQHAI
110 120 130 140 150
EESVVLIYDP IKTGQGYLSL KAYRLTPKLM EVCKEKDFSP EALKKASITF
160 170 180 190 200
ESMFEEVPII IKNSYLINVL LWELEKKSAV AARHELLSLA SNNHLGKSLQ
210 220 230 240 250
LLMDRVDEMS QDIVKYNTYL RNTSKQQQQK HQYQQRRQQE NLQRQSRGEP
260 270 280 290 300
PLPEEDMNKL FKPPQPPPRM ESLLIAGQIN TYSQNVKEFT AQNLGKLFMS
QALQEHSN
Genome annotation databases
Ensembli | ENSACAT00000011149; ENSACAP00000010921; ENSACAG00000011074 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000010921 |
Genome annotation databases
Ensembli | ENSACAT00000011149; ENSACAP00000010921; ENSACAG00000011074 |
Phylogenomic databases
eggNOGi | KOG1560, Eukaryota |
GeneTreei | ENSGT00730000111042 |
HOGENOMi | CLU_044094_0_0_1 |
InParanoidi | G1KKW5 |
OMAi | KFNRYQQ |
TreeFami | TF101504 |
Gene expression databases
Bgeei | ENSACAG00000011074, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
CDDi | cd08065, MPN_eIF3h, 1 hit |
HAMAPi | MF_03007, eIF3h, 1 hit |
InterProi | View protein in InterPro IPR027524, eIF3h IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF3, PTHR10410:SF3, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KKW5_ANOCA | |
Accessioni | G1KKW5Primary (citable) accession number: G1KKW5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | October 7, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |