UniProtKB - G1KKV3 (G1KKV3_ANOCA)
Protein
ALX homeobox protein 1
Gene
ALX1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 137 – 196 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: GO_Central
- negative regulation of transcription, DNA-templated Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural crest cell migration Source: InterPro
- neural tube closure Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: Ensembl
Keywordsi
Molecular function | Developmental proteinPROSITE-ProRule annotationARBA annotation, DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ALX homeobox protein 1ARBA annotationAlternative name(s): Cartilage homeoprotein 1ARBA annotation |
Gene namesi | Name:ALX1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nuclear body Source: Ensembl
- nuclear chromatin Source: GO_Central
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011108, Expressed in forelimb bud and 7 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 195 | HomeoboxInterPro annotationAdd BLAST | 61 | |
Domaini | 311 – 324 | OARInterPro annotationAdd BLAST | 14 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 311 – 324 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the paired homeobox family.ARBA annotation
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | G1KKV3 |
OMAi | FYNKSPA |
OrthoDBi | 738339at2759 |
TreeFami | TF350743 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KKV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFLGDKFGL KGPAAGKGGD FYLSPGAPLE HVMEGLEGGG GGGTGGGGEA
60 70 80 90 100
FYGKGGKCVG QAPYNPHARM ERASPAREGS VTYGITKVEG QPLHTELGRP
110 120 130 140 150
LDNCSSLRLS PVKGMQEKGD LDELGDKCDS NVSSSKKRRH RTTFTSLQLE
160 170 180 190 200
ELEKVFQKTH YPDVYVREQL ALRTELTEAR VQVWFQNRRA KWRKRERYGQ
210 220 230 240 250
IQQAKSHFAA TYDISVLPRT DNYPQIQNNL WAGNAASSSV VTSCMLPRDT
260 270 280 290 300
SSCMTPYSHS PRTDSGYSGF SNHQSQFSHV PLNNFFTDSL LSGTTNGHAF
310 320 330
ETKPEFERRS SSIAVLRMKA KEHTANISWA M
Sequence databases
RefSeqi | XP_003221183.1, XM_003221135.3 |
Genome annotation databases
Ensembli | ENSACAT00000011126; ENSACAP00000010899; ENSACAG00000011108 |
GeneIDi | 100562225 |
KEGGi | acs:100562225 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003221183.1, XM_003221135.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000010899 |
Genome annotation databases
Ensembli | ENSACAT00000011126; ENSACAP00000010899; ENSACAG00000011108 |
GeneIDi | 100562225 |
KEGGi | acs:100562225 |
Organism-specific databases
CTDi | 8092 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | G1KKV3 |
OMAi | FYNKSPA |
OrthoDBi | 738339at2759 |
TreeFami | TF350743 |
Gene expression databases
Bgeei | ENSACAG00000011108, Expressed in forelimb bud and 7 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KKV3_ANOCA | |
Accessioni | G1KKV3Primary (citable) accession number: G1KKV3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |