Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 55 (07 Apr 2021)
Sequence version 1 (19 Oct 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Microtubule-associated protein

Gene

MAP2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000010914, Expressed in testis and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000010845

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini350 – 1461MAP2_projctnInterPro annotationAdd BLAST1112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 89DisorderedSequence analysisAdd BLAST89
Regioni109 – 145DisorderedSequence analysisAdd BLAST37
Regioni172 – 312DisorderedSequence analysisAdd BLAST141
Regioni380 – 453DisorderedSequence analysisAdd BLAST74
Regioni474 – 509DisorderedSequence analysisAdd BLAST36
Regioni703 – 727DisorderedSequence analysisAdd BLAST25
Regioni790 – 830DisorderedSequence analysisAdd BLAST41
Regioni922 – 961DisorderedSequence analysisAdd BLAST40
Regioni1018 – 1044DisorderedSequence analysisAdd BLAST27
Regioni1067 – 1125DisorderedSequence analysisAdd BLAST59
Regioni1137 – 1165DisorderedSequence analysisAdd BLAST29
Regioni1183 – 1229DisorderedSequence analysisAdd BLAST47
Regioni1297 – 1328DisorderedSequence analysisAdd BLAST32
Regioni1357 – 1594DisorderedSequence analysisAdd BLAST238
Regioni1740 – 1759DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili355 – 375Sequence analysisAdd BLAST21
Coiled coili732 – 752Sequence analysisAdd BLAST21
Coiled coili881 – 901Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 43PolarSequence analysisAdd BLAST28
Compositional biasi61 – 75PolarSequence analysisAdd BLAST15
Compositional biasi129 – 143Pro-richSequence analysisAdd BLAST15
Compositional biasi206 – 220PolyampholyteSequence analysisAdd BLAST15
Compositional biasi229 – 259PolyampholyteSequence analysisAdd BLAST31
Compositional biasi260 – 287PolarSequence analysisAdd BLAST28
Compositional biasi413 – 429PolyampholyteSequence analysisAdd BLAST17
Compositional biasi489 – 506PolyampholyteSequence analysisAdd BLAST18
Compositional biasi790 – 816PolarSequence analysisAdd BLAST27
Compositional biasi1067 – 1091PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1183 – 1223PolyampholyteSequence analysisAdd BLAST41
Compositional biasi1357 – 1435PolyampholyteSequence analysisAdd BLAST79
Compositional biasi1442 – 1458BasicSequence analysisAdd BLAST17
Compositional biasi1463 – 1477PolarSequence analysisAdd BLAST15
Compositional biasi1521 – 1588PolarSequence analysisAdd BLAST68

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2418, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002538_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KKT3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIEMPME

TreeFam database of animal gene trees

More...
TreeFami
TF316358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501:SF15, PTHR11501:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KKT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADERKDEAK APHWTSSQLA EASSHSHPPE IKEQSSTSEG LVRSANGFPY
60 70 80 90 100
REDEDGGYGA RGQQSSYSRT KENGINGEVA TGEKETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP APLPLGKEYN CNCPPPPPPP SASVISSQTT
160 170 180 190 200
ADLFAASKME IHVQEGTDLF AAEPLGMKDS EKGSKTSEQS LHDALVLQPA
210 220 230 240 250
KTESIQRAES PDEEEKTPPT LLEQTLDANH QKQELRGSVK TDIDSTRDSD
260 270 280 290 300
QHQEQKDLST QWHQEGQTDE IATTSQKSTS KALPTESKDY QTDLKRYDFP
310 320 330 340 350
SPGSIGSSSL SELTMDTRST VKTIFSSDTL PGAHHKSGSV ETNKRIHIST
360 370 380 390 400
ASDIAKDLMK DHKMDKEKIK KQEEDFAIAT IPSLPPVTEE TSVQNVPLWE
410 420 430 440 450
EEKDMTEDES DEEGYSVSSR QKHRALDDQS FVACADQPTK GAIGKEAEKE
460 470 480 490 500
GKHSMETFAD RFSQELFPEK VEASLNRHAL SEMESPSTEP SDETLHRKDS
510 520 530 540 550
GKNCKDAEFS VGDSVTHKVQ VEEDKSGMST YFETSALKDE SVKSDILLHG
560 570 580 590 600
SDYYELSDTK EQTYDPYHKD FLFAKKDTEE YQPDSYQLPS IPTHEIGYST
610 620 630 640 650
LAQSFPEDEP REPSSPKERI YTIDPNVYGD KRELHNKNKD DLTLSRSLGL
660 670 680 690 700
GGRSAIEQRS MSINLPMSCL DSIALGFNFG RTHDLSPLGS DILDNASGDE
710 720 730 740 750
GDDYLPVTTP AVEKTPTFPT DSREEEEEVV VVEEEEDEKE KIEEPIMKEE
760 770 780 790 800
GEIQVEPSCE SPFLAKDYYK NGNVMAPDLP EMLDLAGTRS RLASASTEAE
810 820 830 840 850
GAQSKSILSE GPEEDSSTTQ HLMKDENHMT LKADSQLEDL GYCVFNKYTV
860 870 880 890 900
PMPSPVQDSE NLTGESCPFD EKIRRGVITD LSLIEVKLAA AERSKEEKEA
910 920 930 940 950
SSDSVLLGKD FEQERKAIDK LDTVLEKSEE PTDSKEAYSS EDAEHTRVKP
960 970 980 990 1000
DSTLETVDDK SLAGVEEKVS LITQKEEDDI HITKTGTPEI SCKPDYDAIK
1010 1020 1030 1040 1050
HDLDSAALQV EQEYQSKLGV HPDESVSGQS TVDRDKIPSV LPEEPIVCAK
1060 1070 1080 1090 1100
LEPCPIKDAT KLSEIEFKEK GAKPDLVHQE AVDKEESYES SGDNDQAQEG
1110 1120 1130 1140 1150
LPGDTSKPYV GKIEPESPSL SEETVSQVLV EQQVVETEVS KATPEEAAEI
1160 1170 1180 1190 1200
QMENIPQSKT DQVESLELAD SVKTEDLVHH LEYEKKDVEG EQQKEVKQPE
1210 1220 1230 1240 1250
EHKEVKQAEE LKEDIKEAEE YEETQAIPGE LPELKGVIES VVTIEDDFIT
1260 1270 1280 1290 1300
IVQTTVDEGD ASSHSVRFAE TQQADIEEEG IHPEEEVDME VVADIKEEKK
1310 1320 1330 1340 1350
DTSLEAPGSP EREEVPLTDY KTETYDDYKD ETTIDDSILD TDSIWVDTQD
1360 1370 1380 1390 1400
DDRSIMTEQL ETVPKEEKAE RELRRPSLDK HKKEKALKTG RGRISTPERK
1410 1420 1430 1440 1450
IAKKEPSTVS RDEVRRKKAV YKKAELSKKA EVQAHSPSRK IILKPAIKHT
1460 1470 1480 1490 1500
RPTHHSCVKR KQTAAAGETN QTPGMFKQAK EKLSDGIIKS PEKRSSLPRP
1510 1520 1530 1540 1550
SSILPTRRGI SADRERDENS SSLNSTISSA RRTTRSEPIR SRTGKSGTST
1560 1570 1580 1590 1600
PTTPGSTAIT PGTPPSYSSR TPGTPGTPSY SRTPHTPGTP RSAILVPTEK
1610 1620 1630 1640 1650
KVAIIRTPPK SPGTPKQLRL INQPLPDLKN VRSKIGSTDN IKYQPKGGQI
1660 1670 1680 1690 1700
QIVTKKIDLS HVTSKCGSLK NIRHRPGGGR VKIESVKLDF KEKAHAKVGS
1710 1720 1730 1740 1750
LENAHHVPGG GHIKIDSQKL NFREHAKARV DHGAEIITQS PGRSSVASPR
1760 1770 1780
RLSNVSSSGS INLLESPQLA TLAEDVTAAL AKQGL
Length:1,785
Mass (Da):197,251
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA30125440272C601
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000011070; ENSACAP00000010845; ENSACAG00000010914

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000010845

Genome annotation databases

EnsembliENSACAT00000011070; ENSACAP00000010845; ENSACAG00000010914

Phylogenomic databases

eggNOGiKOG2418, Eukaryota
GeneTreeiENSGT00940000156597
HOGENOMiCLU_002538_0_0_1
InParanoidiG1KKT3
OMAiFIEMPME
TreeFamiTF316358

Gene expression databases

BgeeiENSACAG00000010914, Expressed in testis and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15, PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KKT3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KKT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again