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Entry version 66 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

TDRD9

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation, HelicaseARBA annotation, Hydrolase
Biological processDifferentiation, MeiosisARBA annotation, RNA-mediated gene silencingARBA annotation, SpermatogenesisARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000010862, Expressed in dewlap and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000010726

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 277Helicase ATP-bindingInterPro annotationAdd BLAST167
Domaini343 – 511Helicase C-terminalInterPro annotationAdd BLAST169
Domaini912 – 972TudorInterPro annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0920, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002601_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KKN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPCRTVY

Database of Orthologous Groups

More...
OrthoDBi
278674at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324869

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF00567, TUDOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SM00333, TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50304, TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KKN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKKLTLDQI NDWFTIGKKV TQVEFLGRFA SAPLASEESS DTHEIPKKNN
60 70 80 90 100
TDTEYVAKYR QLETEELIET DSSWPPCKPE SQHDASPVTC VPVGNYKYPD
110 120 130 140 150
LPISGYKEQL LSLIENNSVV IIHGSTGSGK STLLPQFVLD HFEQRSTYCN
160 170 180 190 200
IIVTQPRKIG ASSIARWITK QRSWPLGERV GYQVGLEKVA SEKTRLLYAT
210 220 230 240 250
TGILLQKLVG SKTLSEFTHI FIDEVHERTE VMDFLLLVVR KLLRTNSRFV
260 270 280 290 300
KVILMSATIN CQEFAEYFAI PVRNKLYPAY VFEVEGKPHA IEEYYLDDLT
310 320 330 340 350
HVISHIMTCF QAAEDPQIYT EMYNAAVALI MWFDKLEIQE SGAENPNLEY
360 370 380 390 400
MSERGSVLVF LPGLEEINYM HELLTDMAYR RLQVYPLHSS ITLEEQTNVF
410 420 430 440 450
LAPVPGYRKI LLSTNIAESS VTVPDVKYVI DFCLTRTLVC DEDTNYQSLR
460 470 480 490 500
LCWASKSSCN QRKGRAGRVS KGYCYRLVYK DFWTRCIPET SIPEMMRCPL
510 520 530 540 550
ETTILKVKQL DMGEPRALLA TALSPPSICD IEQTILRLKE IGALAVDVPS
560 570 580 590 600
EEQNPYDGEL TFLGRVLADL PVDQHLGKLI VLGHVFGCLD ECLIIAAALS
610 620 630 640 650
LNNFFSVPFR QHFDSYRNKM HFAGNSRSDC IALVDAFKEW QESRKNGKLR
660 670 680 690 700
HPKDELDWGR SNYIHIKRIR EVAELYEELK KRVGKFNIHV YTQPPAMDRE
710 720 730 740 750
HVYKQRFILQ VVMAGAFYPN YFNVGEYDDE IAVRELLGEN PKTTVVLKNI
760 770 780 790 800
PPFGYLYHEQ LQSLFRQCGQ VKSISYDGTK AFIEFSRNPT QTFKVLPAVY
810 820 830 840 850
LALKMTQLRM QLELNIHSPE EIESKMGRGT VAAVRSSRVN MHFQKHTVTT
860 870 880 890 900
VNFTNELEKL PTINSLDLSI SVTEVVEVGH FWGYRIDDKS MKILKGLCAE
910 920 930 940 950
INELKLTPLP VRPHPDLVCL APFTDWEDER YYRAQILYVS GENAEIFYVD
960 970 980 990 1000
YGNRSKVALN LLREIPSHLR ELPFQALEFK VRRMRPSAHS LVCGEQWSYA
1010 1020 1030 1040 1050
ASQRFAALVN GCALMVKVFS IVHSILHVDV LRYSGTMEIV NIRDVLIQEH
1060 1070 1080 1090 1100
HAELADDSYE SVQSNENLKL VFSNPEANSK NGSSFIRNSS KEETRIIKML
1110 1120 1130 1140 1150
LESCSGNQFG TPKCKARLIG PFNPYNLKFS SMTRVSRFRT VLVMRESVNS
1160 1170 1180 1190 1200
VVVADDPENS FQQILVASSV SINATGTTML LRETSLMPHI PGLPALLAML
1210 1220 1230 1240 1250
FAPVIELRID EKQTRYTGVL CGLGWNRSLG TPVFQDHDME LTFDVEIDTE
1260 1270 1280 1290 1300
DMTQINILRM AINKLVSDGP NGLLNFGQVR ISQLQQSARD KLLSLICKSK
1310 1320 1330 1340 1350
PRNVIPPKWY ANVHEWNQLK PSLLIDQSDL RSARGMNSCL YQLHNLVLLN

A
Length:1,351
Mass (Da):153,947
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i255F89BE98A705CC
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008103656.1, XM_008105449.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000010948; ENSACAP00000010726; ENSACAG00000010862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100559430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100559430

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008103656.1, XM_008105449.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000010726

Genome annotation databases

EnsembliENSACAT00000010948; ENSACAP00000010726; ENSACAG00000010862
GeneIDi100559430
KEGGiacs:100559430

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
122402

Phylogenomic databases

eggNOGiKOG0920, Eukaryota
GeneTreeiENSGT00940000157035
HOGENOMiCLU_002601_1_0_1
InParanoidiG1KKN5
OMAiDPCRTVY
OrthoDBi278674at2759
TreeFamiTF324869

Gene expression databases

BgeeiENSACAG00000010862, Expressed in dewlap and 2 other tissues

Family and domain databases

CDDicd04508, TUDOR, 1 hit
Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF00567, TUDOR, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SM00333, TUDOR, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50304, TUDOR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KKN5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KKN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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