UniProtKB - G1KKD1 (G1KKD1_ANOCA)
Protein
DNA mismatch repair protein
Gene
MSH3
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- dinucleotide repeat insertion binding Source: Ensembl
- DNA-dependent ATPase activity Source: GO_Central
- DNA insertion or deletion binding Source: GO_Central
- enzyme binding Source: Ensembl
- single guanine insertion binding Source: Ensembl
- single-stranded DNA binding Source: Ensembl
GO - Biological processi
- maintenance of DNA repeat elements Source: GO_Central
- meiotic mismatch repair Source: GO_Central
- mismatch repair Source: GO_Central
- mitotic recombination Source: GO_Central
- negative regulation of DNA recombination Source: Ensembl
- positive regulation of helicase activity Source: GO_Central
- reciprocal meiotic recombination Source: GO_Central
- removal of nonhomologous ends Source: GO_Central
- replication fork arrest Source: GO_Central
- somatic recombination of immunoglobulin gene segments Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairUniRule annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: DNA mismatch repair proteinUniRule annotation |
Gene namesi | Name:MSH3Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- MutSbeta complex Source: GO_Central
Other locations
- mismatch repair complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000010533, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000010450 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 932 – 948 | DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST | 17 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the DNA mismatch repair MutS family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0218, Eukaryota |
GeneTreei | ENSGT00550000074949 |
HOGENOMi | CLU_002472_0_1_1 |
InParanoidi | G1KKD1 |
OrthoDBi | 138168at2759 |
TreeFami | TF300525 |
Family and domain databases
Gene3Di | 3.30.420.110, 1 hit 3.40.1170.10, 1 hit |
InterProi | View protein in InterPro IPR007695, DNA_mismatch_repair_MutS-lik_N IPR017261, DNA_mismatch_repair_MutS/MSH IPR000432, DNA_mismatch_repair_MutS_C IPR007696, DNA_mismatch_repair_MutS_core IPR016151, DNA_mismatch_repair_MutS_N IPR036187, DNA_mismatch_repair_MutS_sf IPR007860, DNA_mmatch_repair_MutS_con_dom IPR036678, MutS_con_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01624, MutS_I, 1 hit PF05188, MutS_II, 1 hit PF05192, MutS_III, 1 hit PF00488, MutS_V, 1 hit |
PIRSFi | PIRSF037677, DNA_mis_repair_Msh6, 1 hit |
SMARTi | View protein in SMART SM00534, MUTSac, 1 hit SM00533, MUTSd, 1 hit |
SUPFAMi | SSF48334, SSF48334, 1 hit SSF52540, SSF52540, 1 hit SSF53150, SSF53150, 1 hit SSF55271, SSF55271, 1 hit |
PROSITEi | View protein in PROSITE PS00486, DNA_MISMATCH_REPAIR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KKD1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRGRRRPEP GGGARGQPVL SKFFPPIPRV PSGAAERSDG PAVAPHTPHE
60 70 80 90 100
PERKKRRSIK NKVHVDKYSG PLQNIEKEDD ETVNTAEPKT YTRPQICSAT
110 120 130 140 150
LDRLREFSSS MEHPSKRIHA EAFHETQSLE FKKCNHSVTG NEKISETAHP
160 170 180 190 200
ENIDKEKMCF NINQFSASST SFENNQNSSI TSINKSTKGG YTPLELQFLE
210 220 230 240 250
MKNQYKDAIL CVECGYKYRF FGEDAEIAAK ELNIYCHKNH NFMSASIPTH
260 270 280 290 300
RLFVHVRRLV AKGYKVGVVK QIETAALKAA GENRSSLFAR KLTALYTKST
310 320 330 340 350
ILGEDVNPLL KLNNLVDAEE IPSDVCDNYL LCISESKENI RDKNQDVHIG
360 370 380 390 400
VVAVQPTTGE VIFDSFQDSA ARLELESLIL RLQPVEIILP KDVSDQTENI
410 420 430 440 450
ISAVTSLRLQ DDRIRIERME NKLFENSSAF QLITDFYSNQ VLDSTGSHAL
460 470 480 490 500
SVLVKLDKIV LCSLAAVIVY LKQFNLERIL YNPSNFKMLS SEPEYMTLNG
510 520 530 540 550
ITLKNLEILQ NQSDMKSNGS LFWILDHTKT SFGRRRLKKW VTQPLLKSSE
560 570 580 590 600
INSRLDAVSE VLMSESSVLI QIKTLLHKMP DVERGICSIY HKKCSTQEFF
610 620 630 640 650
LIVSTLSQLE ASITALVPAI QTQVQAALLR KNLLEISDLL SPVKKYLSIL
660 670 680 690 700
NEEAAKSGDK TQLFKDLQDF PLIRSRKDEI QAVLYQIQMH LQDIRKILKC
710 720 730 740 750
SFAGYVTVSG QEFQIEVKNS LVFSVPSDWI QVSSTKAVSR FHTPFIVENY
760 770 780 790 800
RHLNQLREQL VLDCNAEWLR FLDDFSDHYY SISKAVGHLA TVDCIFSLAE
810 820 830 840 850
VAKQGDYCRP VVKDGRSEIM IKNGKHPVID VLLGEQEQYV PNDTHIVCDG
860 870 880 890 900
QRAMIITGPN MGGKSSYIKQ VALITLMAQI GSYVPAEEVR VGIVDGIFTR
910 920 930 940 950
MGATDNIFKG HSTFMEELTD TADIIRKATS HSLVILDELG RGTSTHDGIA
960 970 980 990 1000
IAYATLEYFI RDVGSLTLFV THYPPLCELE RAYPRQVGNY HMAFLVNEDD
1010 1020 1030 1040 1050
SEQKRGMKDE ENPEFVTFLY QIKKEVAARS YGLNVAKLAD VPEEILKKAA
1060 1070 1080 1090
HKSKELERFV DIKRKRLLIF AELWNIHSAG ELQKWKNMCE SDQIQP
Sequence databases
RefSeqi | XP_008101196.1, XM_008102989.2 |
Genome annotation databases
Ensembli | ENSACAT00000010665; ENSACAP00000010450; ENSACAG00000010533 |
GeneIDi | 100554606 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008101196.1, XM_008102989.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000010450 |
Genome annotation databases
Ensembli | ENSACAT00000010665; ENSACAP00000010450; ENSACAG00000010533 |
GeneIDi | 100554606 |
Organism-specific databases
CTDi | 4437 |
Phylogenomic databases
eggNOGi | KOG0218, Eukaryota |
GeneTreei | ENSGT00550000074949 |
HOGENOMi | CLU_002472_0_1_1 |
InParanoidi | G1KKD1 |
OrthoDBi | 138168at2759 |
TreeFami | TF300525 |
Gene expression databases
Bgeei | ENSACAG00000010533, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 3.30.420.110, 1 hit 3.40.1170.10, 1 hit |
InterProi | View protein in InterPro IPR007695, DNA_mismatch_repair_MutS-lik_N IPR017261, DNA_mismatch_repair_MutS/MSH IPR000432, DNA_mismatch_repair_MutS_C IPR007696, DNA_mismatch_repair_MutS_core IPR016151, DNA_mismatch_repair_MutS_N IPR036187, DNA_mismatch_repair_MutS_sf IPR007860, DNA_mmatch_repair_MutS_con_dom IPR036678, MutS_con_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01624, MutS_I, 1 hit PF05188, MutS_II, 1 hit PF05192, MutS_III, 1 hit PF00488, MutS_V, 1 hit |
PIRSFi | PIRSF037677, DNA_mis_repair_Msh6, 1 hit |
SMARTi | View protein in SMART SM00534, MUTSac, 1 hit SM00533, MUTSd, 1 hit |
SUPFAMi | SSF48334, SSF48334, 1 hit SSF52540, SSF52540, 1 hit SSF53150, SSF53150, 1 hit SSF55271, SSF55271, 1 hit |
PROSITEi | View protein in PROSITE PS00486, DNA_MISMATCH_REPAIR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KKD1_ANOCA | |
Accessioni | G1KKD1Primary (citable) accession number: G1KKD1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | August 12, 2020 | |
This is version 60 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |