UniProtKB - G1KJV8 (G1KJV8_ANOCA)
Protein
ZnMc domain-containing protein
Gene
MMP16
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 254 | UniRule annotation | 1 |
GO - Molecular functioni
- metalloaminopeptidase activity Source: Ensembl
- metalloendopeptidase activity Source: GO_Central
- zinc ion binding Source: Ensembl
GO - Biological processi
- chondrocyte proliferation Source: Ensembl
- collagen catabolic process Source: GO_Central
- craniofacial suture morphogenesis Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: Ensembl
- endochondral ossification Source: Ensembl
- extracellular matrix organization Source: GO_Central
- protein processing Source: Ensembl
- skeletal system development Source: GO_Central
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | CalciumARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation |
Protein family/group databases
MEROPSi | M10.016 |
Names & Taxonomyi
Protein namesi | Recommended name: ZnMc domain-containing proteinInterPro annotation |
Gene namesi | Name:MMP16Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Source: InterPro
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 572 – 593 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 39 | Sequence analysisAdd BLAST | 39 | |
ChainiPRO_5003412739 | 40 – 615 | ZnMc domain-containing proteinSequence analysisAdd BLAST | 576 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, ZymogenARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000010198, Expressed in hemipenis and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 299 | ZnMcInterPro annotationAdd BLAST | 170 | |
Repeati | 348 – 396 | HemopexinPROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 397 – 442 | HemopexinPROSITE-ProRule annotationAdd BLAST | 46 | |
Repeati | 444 – 492 | HemopexinPROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 493 – 540 | HemopexinPROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 289 – 349 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 302 – 320 | Pro-richSequence analysisAdd BLAST | 19 | |
Compositional biasi | 321 – 335 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the peptidase M10A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000157532 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | G1KJV8 |
TreeFami | TF352396 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028697, MMP16 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF26, PTHR10201:SF26, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
G1KJV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLRAFRTAS RGDFAHQSRV FVLQALLWIL CAAAAGCRAE QYFNVEVWLQ
60 70 80 90 100
KYGYLPPTDP RMSVLRTAET MKSAIAAMQQ FYGINMTGKV DRNTIDDITL
110 120 130 140 150
SWMKKPRCGV PDQTRGNSRF NIRRKRYALT GQKWQHKHIT YSIKNVTPKV
160 170 180 190 200
GDAETRKAIR RAFDVWQNVT PLTFEEVPYI ELENGKRDVD ITIIFASGFH
210 220 230 240 250
GDSSPFDGEG GFLAHAYFPG PGIGGDTHFD SDEPWTLGNP NHDGNDLFLV
260 270 280 290 300
AVHELGHALG LEHSNDPTAI MAPFYQYMET DNFKLPNDDL QGIQKIYGPP
310 320 330 340 350
DKISPPTKPL PTVPPHRSVP PVDPRKNDRP KPPRQPPGDK PPYPGAKPNI
360 370 380 390 400
CDGNFNTLAI LRREMFVFKD QWFWRVRNNR VMDGYPMQIT YFWRGLPPSI
410 420 430 440 450
DAVYENSDGN FVFFKGNKFW VFKDTTLQPG YPHDLITLGN GIPPHGIDSA
460 470 480 490 500
IWWEDVGKTY FFKGDRYWRY SEDIRTMDAG YPKPITIWKG VPESPQGAFI
510 520 530 540 550
HKENGFTYFY KGKEYWKFNN QMLRVEPGYP RSILKDFMGC DGPADRDKDR
560 570 580 590 600
HSPQDDVDIV IKLDNTASTV KAIAIVIPCI LALCLLVLVY TVFQFKRKGT
610
PRHILYCKRS MQEWV
Genome annotation databases
Ensembli | ENSACAT00000010236; ENSACAP00000010029; ENSACAG00000010198 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000010029 |
Protein family/group databases
MEROPSi | M10.016 |
Genome annotation databases
Ensembli | ENSACAT00000010236; ENSACAP00000010029; ENSACAG00000010198 |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000157532 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | G1KJV8 |
TreeFami | TF352396 |
Gene expression databases
Bgeei | ENSACAG00000010198, Expressed in hemipenis and 14 other tissues |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028697, MMP16 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF26, PTHR10201:SF26, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KJV8_ANOCA | |
Accessioni | G1KJV8Primary (citable) accession number: G1KJV8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |