UniProtKB - G1KJT8 (G1KJT8_ANOCA)
Protein
Furin-like_2 domain-containing protein
Gene
RSPO2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
- signaling receptor binding Source: Ensembl
GO - Biological processi
- bone mineralization Source: Ensembl
- dopaminergic neuron differentiation Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- epithelial tube branching involved in lung morphogenesis Source: Ensembl
- lung growth Source: Ensembl
- negative regulation of odontogenesis of dentin-containing tooth Source: Ensembl
- osteoblast differentiation Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- trachea cartilage morphogenesis Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Heparin-bindingARBA annotation |
Biological process | Sensory transductionARBA annotation, Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Furin-like_2 domain-containing proteinInterPro annotation |
Gene namesi | Name:RSPO2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: Ensembl
Other locations
- cell surface Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003412737 | 22 – 241 | Furin-like_2 domain-containing proteinSequence analysisAdd BLAST | 220 |
Expressioni
Gene expression databases
Bgeei | ENSACAG00000010188, Expressed in forelimb bud and 11 other tissues |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009991 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 141 | Furin-like_2InterPro annotationAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 204 – 241 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 204 – 224 | BasicSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the R-spondin family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000159194 |
HOGENOMi | CLU_064219_1_0_1 |
InParanoidi | G1KJT8 |
OrthoDBi | 1441603at2759 |
TreeFami | TF331799 |
Family and domain databases
CDDi | cd00064, FU, 1 hit |
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR006212, Furin_repeat IPR009030, Growth_fac_rcpt_cys_sf IPR042993, RSPO2/4 IPR043601, Rspo_Fu-CRD_dom IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
PANTHERi | PTHR46987:SF4, PTHR46987:SF4, 1 hit |
Pfami | View protein in Pfam PF15913, Furin-like_2, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 2 hits SM00209, TSP1, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50092, TSP1, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KJT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQFRLFSFAL IVLNCMDYSH CQGARWRRSK RANYGPNPIC KGCLSCSKDN
60 70 80 90 100
GCIRCQHKLF FFLRREGMRQ YGECLNSCPS GYYGLRAPDM NRCSRCRIEN
110 120 130 140 150
CDSCFSRDFC TKCKPGFYLY RGRCFGECPD GFMPLEETME CVEGCEVGPW
160 170 180 190 200
SEWGICSRNN KTCGFKWGLE TRTRQIVKKP AKDTLPCPTI AESRRCKMAL
210 220 230 240
RHCPGGKRTP KTKDKKKKKK NLMERAQKQH SLFLSTDRAG Q
Sequence databases
RefSeqi | XP_008106458.1, XM_008108251.2 XP_016848253.1, XM_016992764.1 |
Genome annotation databases
Ensembli | ENSACAT00000010197; ENSACAP00000009991; ENSACAG00000010188 |
GeneIDi | 100563273 |
KEGGi | acs:100563273 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008106458.1, XM_008108251.2 XP_016848253.1, XM_016992764.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009991 |
Genome annotation databases
Ensembli | ENSACAT00000010197; ENSACAP00000009991; ENSACAG00000010188 |
GeneIDi | 100563273 |
KEGGi | acs:100563273 |
Organism-specific databases
CTDi | 340419 |
Phylogenomic databases
eggNOGi | KOG3525, Eukaryota |
GeneTreei | ENSGT00940000159194 |
HOGENOMi | CLU_064219_1_0_1 |
InParanoidi | G1KJT8 |
OrthoDBi | 1441603at2759 |
TreeFami | TF331799 |
Gene expression databases
Bgeei | ENSACAG00000010188, Expressed in forelimb bud and 11 other tissues |
Family and domain databases
CDDi | cd00064, FU, 1 hit |
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR006212, Furin_repeat IPR009030, Growth_fac_rcpt_cys_sf IPR042993, RSPO2/4 IPR043601, Rspo_Fu-CRD_dom IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
PANTHERi | PTHR46987:SF4, PTHR46987:SF4, 1 hit |
Pfami | View protein in Pfam PF15913, Furin-like_2, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 2 hits SM00209, TSP1, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50092, TSP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KJT8_ANOCA | |
Accessioni | G1KJT8Primary (citable) accession number: G1KJT8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |