UniProtKB - G1KJG1 (G1KJG1_ANOCA)
Protein
Isocitrate dehydrogenase [NADP]
Gene
IDH1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- EC:1.1.1.42UniRule annotationARBA annotation
Cofactori
Protein has several cofactor binding sites:- Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation
- Mn2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 77 | SubstrateUniRule annotation | 1 | |
Binding sitei | 82 | NADPUniRule annotation | 1 | |
Binding sitei | 109 | SubstrateUniRule annotation | 1 | |
Binding sitei | 132 | SubstrateUniRule annotation | 1 | |
Sitei | 139 | Critical for catalysisUniRule annotation | 1 | |
Sitei | 212 | Critical for catalysisUniRule annotation | 1 | |
Metal bindingi | 252 | Magnesium or manganeseUniRule annotation | 1 | |
Binding sitei | 260 | NADPUniRule annotation | 1 | |
Metal bindingi | 275 | Magnesium or manganeseUniRule annotation | 1 | |
Binding sitei | 328 | NADP; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 75 – 77 | NADPUniRule annotation | 3 | |
Nucleotide bindingi | 310 – 315 | NADPUniRule annotation | 6 |
GO - Molecular functioni
- isocitrate dehydrogenase (NADP+) activity Source: GO_Central
- magnesium ion binding Source: Ensembl
- NAD binding Source: InterPro
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- 2-oxoglutarate metabolic process Source: Ensembl
- glutathione metabolic process Source: Ensembl
- glyoxylate cycle Source: UniProtKB-KW
- isocitrate metabolic process Source: GO_Central
- NADP metabolic process Source: GO_Central
- regulation of phospholipid biosynthetic process Source: Ensembl
- regulation of phospholipid catabolic process Source: Ensembl
- response to oxidative stress Source: Ensembl
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Biological process | Glyoxylate bypassARBA annotation, Tricarboxylic acid cycleUniRule annotationARBA annotation |
Ligand | MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:IDH1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: GO_Central
Peroxisome
- peroxisome Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000009873, Expressed in kidney and 14 other tissues |
Interactioni
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009704 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 401 | Iso_dhInterPro annotationAdd BLAST | 393 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 100 | Substrate bindingUniRule annotation | 7 |
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotationARBA annotation
Phylogenomic databases
eggNOGi | KOG1526, Eukaryota |
GeneTreei | ENSGT00390000012547 |
HOGENOMi | CLU_023296_1_1_1 |
InParanoidi | G1KJG1 |
OMAi | HGTVQRH |
OrthoDBi | 769322at2759 |
TreeFami | TF300428 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KJG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKKINGGSV VEMQGDEMTR IIWELIKEKL IFPYVDLDLH SYDLGIEHRD
60 70 80 90 100
ATDDKVTVEA AEAIRKYNVG IKCATITPDE KRVEEFKLKQ MWKSPNGTIR
110 120 130 140 150
NILGGTVFRE AIICKNIPRL VSGWTKPIII GRHAYGDQYR ATDFVVPGPG
160 170 180 190 200
KVEMIYTPKD GSKPVTYLVH NFESCGGVAL GMYNLDQSIK DFAHSSFQMA
210 220 230 240 250
LSKAWPLYMS TKNTILKKYD GRFKDIFQEI YENQYKSKFE AKNIWYEHRL
260 270 280 290 300
IDDMVAQALK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLICPDG
310 320 330 340 350
KTVEAEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNT
360 370 380 390 400
ELKNFATALE EVCVETIEAG FMTKDLSACI KGLPNVKRSD YLNTFEFLDK
410
LAENLKAKLS SQPRL
Sequence databases
RefSeqi | XP_003220054.1, XM_003220006.2 |
Genome annotation databases
Ensembli | ENSACAT00000009903; ENSACAP00000009704; ENSACAG00000009873 |
GeneIDi | 100566676 |
KEGGi | acs:100566676 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003220054.1, XM_003220006.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009704 |
Genome annotation databases
Ensembli | ENSACAT00000009903; ENSACAP00000009704; ENSACAG00000009873 |
GeneIDi | 100566676 |
KEGGi | acs:100566676 |
Organism-specific databases
CTDi | 3417 |
Phylogenomic databases
eggNOGi | KOG1526, Eukaryota |
GeneTreei | ENSGT00390000012547 |
HOGENOMi | CLU_023296_1_1_1 |
InParanoidi | G1KJG1 |
OMAi | HGTVQRH |
OrthoDBi | 769322at2759 |
TreeFami | TF300428 |
Gene expression databases
Bgeei | ENSACAG00000009873, Expressed in kidney and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KJG1_ANOCA | |
Accessioni | G1KJG1Primary (citable) accession number: G1KJG1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |