UniProtKB - G1KJ27 (G1KJ27_ANOCA)
Protein
F-BAR domain only protein 2
Gene
FCHO2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- cytoskeletal protein binding Source: GO_Central
- identical protein binding Source: Ensembl
- phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
- phosphatidylserine binding Source: Ensembl
GO - Biological processi
- clathrin coat assembly Source: GO_Central
- clathrin-dependent endocytosis Source: GO_Central
- membrane invagination Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- synaptic vesicle endocytosis Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: F-BAR domain only protein 2ARBA annotation |
Gene namesi | Name:FCHO2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- clathrin-coated pit ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- cytoskeleton Source: GO_Central
Plasma Membrane
- clathrin-coated pit Source: GO_Central
- plasma membrane Source: GO_Central
Other locations
- clathrin-coated vesicle Source: GO_Central
- cytoplasm Source: GO_Central
- presynapse Source: GOC
Expressioni
Gene expression databases
Bgeei | ENSACAG00000009572, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: GO_Central
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009380 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 250 | F-BARInterPro annotationAdd BLAST | 248 | |
Domaini | 571 – 756 | MHDInterPro annotationAdd BLAST | 186 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 300 – 372 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 388 – 428 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 471 – 556 | DisorderedSequence analysisAdd BLAST | 86 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 87 – 107 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 136 – 156 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 357 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 388 – 420 | PolarSequence analysisAdd BLAST | 33 | |
Compositional biasi | 527 – 556 | PolarSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the FCHO family.ARBA annotation
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000157105 |
HOGENOMi | CLU_007107_0_0_1 |
InParanoidi | G1KJ27 |
TreeFami | TF328986 |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030122, FCHo2 IPR028565, MHD IPR018808, Muniscin_C |
PANTHERi | PTHR23065:SF8, PTHR23065:SF8, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF10291, muHD, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51072, MHD, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KJ27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVMAYFVESF WGERNNGFDV LYHNMKHGHV STKELADFIR ERAAIEETYS
60 70 80 90 100
RSMTKLAKSA SNYSQIGTFS PVWEVFKSST EKLASCHLEL VRKLQELIKE
110 120 130 140 150
VQKYGDEQIK AHKKTKEEVS GTLEAVQTIQ SITQALQKAK ENYNSKCVEQ
160 170 180 190 200
ERLKKEGATQ REIDKAAVKS KKATDAYRLY VEKYAAAKSD FEHKMTETAQ
210 220 230 240 250
KFQDIEEMHL LHMKEIIECF SNTVKEVHVQ IGEVHEEFIN NMTNTTVESL
260 270 280 290 300
VQKFAESKGT GKERPGLIEF EECNTASAVE GIKPRKRKHF GLPGIIKKEK
310 320 330 340 350
DTESVECPDA DSVNIPDVDD EGYSIKPEAS QNAKENHFYS SSDSDSEDDE
360 370 380 390 400
PRKFHVEIKP VQPNNSSHYT MPSLDELKES IGNITLSPAI SRHSPAQMNR
410 420 430 440 450
NSSSEELTKS KLSAPSNEKG NNDLLAWDPL FRNSGDSSSL ASTMSSSSSA
460 470 480 490 500
QSISLQKSSS SSCIMQKDNS ANTISTSARP TTPLSVGTLV PPPRPASRPK
510 520 530 540 550
LTTAKLSGIN EIPRPFSPPL TSSSSPPPSA PLARAESSSS ISSSASMSAA
560 570 580 590 600
NTPTIGISRG PSPVSLGNQD LLPVAVALTE SVNAYFKGAD PTKCIVKITG
610 620 630 640 650
DMTVSFPSGI IKVFTSNPSP AVLCFRVKNT SKLEQILPNA QLVYSDPSQS
660 670 680 690 700
DSNARDFWMD MQAVTVYLKK LSEQNPSASY YNVDVLKYQV SSNGIQSTPL
710 720 730 740 750
NLATYWKCNA NTTDVRVDYK YNPASMAAPS MLSNIQVVVP VDGGVMNMQS
LPAAKW
Genome annotation databases
Ensembli | ENSACAT00000009575; ENSACAP00000009380; ENSACAG00000009572 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009380 |
Genome annotation databases
Ensembli | ENSACAT00000009575; ENSACAP00000009380; ENSACAG00000009572 |
Phylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000157105 |
HOGENOMi | CLU_007107_0_0_1 |
InParanoidi | G1KJ27 |
TreeFami | TF328986 |
Gene expression databases
Bgeei | ENSACAG00000009572, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030122, FCHo2 IPR028565, MHD IPR018808, Muniscin_C |
PANTHERi | PTHR23065:SF8, PTHR23065:SF8, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF10291, muHD, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51072, MHD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KJ27_ANOCA | |
Accessioni | G1KJ27Primary (citable) accession number: G1KJ27 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | October 7, 2020 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |