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Entry version 71 (07 Apr 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

MYH2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi181 – 188ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000017325, Expressed in skeletal muscle tissue and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000009228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 84Myosin N-terminal SH3-likeInterPro annotationAdd BLAST50
Domaini88 – 784Myosin motorInterPro annotationAdd BLAST697

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni661 – 683Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni999 – 1048DisorderedSequence analysisAdd BLAST50
Regioni1127 – 1149DisorderedSequence analysisAdd BLAST23
Regioni1638 – 1657DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1170 – 1190Sequence analysisAdd BLAST21
Coiled coili1199 – 1268Sequence analysisAdd BLAST70
Coiled coili1283 – 1303Sequence analysisAdd BLAST21
Coiled coili1311 – 1380Sequence analysisAdd BLAST70
Coiled coili1382 – 1444Sequence analysisAdd BLAST63
Coiled coili1459 – 1602Sequence analysisAdd BLAST144

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161336

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KIW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMIQTRE

TreeFam database of animal gene trees

More...
TreeFami
TF314375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IIMTSDAEMA VFGEAAPFLR KPEKERIEAQ NRPFDAKIST FVVDEKEMYV
60 70 80 90 100
KGIIQSREAG KVTVKTLDDR TVTVKDDEVF PMNPPKFDKI EDMVMMTHLH
110 120 130 140 150
EPAVLYNLKE RYASWMIYTY SGLFCVTVNP YKWLPVYNPE VVSGYRGKKR
160 170 180 190 200
QEAPPHIFSI SDNAYQFMLT DRENQSVLIT GESGAGKTVN TKRVIQYFAT
210 220 230 240 250
IAVAGDKKKE AQPSKMQGTL EDQIIQANPL LEAFGNAKTV RNDNSSRFGK
260 270 280 290 300
FIRIHFGTTG KLASADIETY LLEKSRVTFQ LSAERSYHIF YQIMSNKKPE
310 320 330 340 350
LIDLLLISTN PYDFPFVSQG ELTVASIDDS EELLATDSAI DILGFSAEEK
360 370 380 390 400
VGIYKLTGAV MHYGNLKFKQ KQREEQAEPD GTEVADKAGY LMGLNSADLL
410 420 430 440 450
KGLCYPRVKV GNEYVTKGQN VQQVYNSVGA LAKSVYEKMF LWMVTRINQQ
460 470 480 490 500
LDTKQPRQHF IGVLDIAGFE IFDYNSLEQL CINFTNEKLQ QFFNHHMFVL
510 520 530 540 550
EQEEYKKEGI DWEFIDFGMD LAACIELIEK PMGIFSILEE ECMFPKATDT
560 570 580 590 600
SFKNKLYDQH LGKSNNFQKP KPVKGKAEAH FSLVHYAGTV DYNITGWLDK
610 620 630 640 650
NKDPLNESVV ALYQKSSLKL LSFLYSNYAA TEAGEGGGSK KGGKKKGGSF
660 670 680 690 700
QTVSAVFREN LNKLMTNLRS THPHFVRCLI PNETKTPGIM DHHLVMHQLR
710 720 730 740 750
CNGVLEGIRI CRKGFPSRIL YADFKQRYKI LNASAIPEGQ FIDSKKASEK
760 770 780 790 800
LLSSIDVDHN QYRFGHTKVF FKAGLLGLLE EMRDEKLVAL ITHTQAMCRG
810 820 830 840 850
FLMRVEFQKM NARRESIYVI QYNVRSFMNV KHWPWMKLYF KIKPLLRSAE
860 870 880 890 900
SEKEMANMKE EFEKTKEDLA KSEAKRKELE EKMVTLVQEK NDLQLQVQSE
910 920 930 940 950
TESLADAEER CEGLIKSKIQ LEAKIKELTE RLEDEEEMNA ELTAKKRKLE
960 970 980 990 1000
DECSELKKDI DDLELTLAKV EKEKHATENK VKNLTEEMAA LDESISKLSK
1010 1020 1030 1040 1050
EKKSLQEAHQ QTLDDLQAEE DKVNTLSKTK SKLEQQVDDL EGSLEQEKKL
1060 1070 1080 1090 1100
RMDLERAKRK LEGDLKMSQE SVMDLENDKQ QMDDKLKKKE FEIGQLQGKI
1110 1120 1130 1140 1150
EDEQAQSSQL QKKIKELQAR MEELEEEIEA ERASRAKAEK QRSDLSRELE
1160 1170 1180 1190 1200
EISERLEEAG GATSAQIEMN KKREAEFQKM RRDLEEATLN HEATTAALRK
1210 1220 1230 1240 1250
KHADSVAELG EQIDNLQRVK QKLEKEKSEL KMEIDDLASN MESVSKAKSN
1260 1270 1280 1290 1300
LEKMCRTLED QFNEIKTKDE EHVRLINDLN AHKARLNTEN GEFSRQLEEK
1310 1320 1330 1340 1350
ESLISQLIRG KQAFTQQTEE LKRQLEEENK AKNALAHALQ SARHDCDLLR
1360 1370 1380 1390 1400
EQFEEEQEAK GELQRAMSKA NSEVAQWRTK YETDAIQRTE ELEEAKKKLA
1410 1420 1430 1440 1450
QRLQESEEQT EAVNSKCASL EKTKQRLQGE VDDLMIDVER SNAACAALDK
1460 1470 1480 1490 1500
RQRNFDKVLA EWKQKYQECQ AELESSQKES RSLSTEIFKM KNAYEEVLDQ
1510 1520 1530 1540 1550
LETVRRENKN LQQEISDLTE QIAEAGKSSH ELEKAKKHVE QERSDLQAAL
1560 1570 1580 1590 1600
EEAEGSLEHE EGKILRVQLE LNQLKSEIDR KVAEKDEEIE QLKRNHQRMM
1610 1620 1630 1640 1650
DTMQSTLDSE VRSRNDALRI KKKMEGDLNE MEIQLSHANR QAAETQKHLR

NVQGQLK
Length:1,657
Mass (Da):190,688
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89DAA24B9D650A0D
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000009421; ENSACAP00000009228; ENSACAG00000017325

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000009228

Genome annotation databases

EnsembliENSACAT00000009421; ENSACAP00000009228; ENSACAG00000017325

Phylogenomic databases

eggNOGiKOG0161, Eukaryota
GeneTreeiENSGT00940000161336
HOGENOMiCLU_000192_8_1_1
InParanoidiG1KIW2
OMAiGMIQTRE
TreeFamiTF314375

Gene expression databases

BgeeiENSACAG00000017325, Expressed in skeletal muscle tissue and 3 other tissues

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KIW2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KIW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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