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Entry version 68 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

SBF2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SBF2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000009005, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000008996

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 424UDENNInterPro annotationAdd BLAST418
Domaini1106 – 1587Myotubularin phosphataseInterPro annotationAdd BLAST482
Domaini1746 – 1850PHInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1074 – 1100DisorderedSequence analysisAdd BLAST27
Regioni1711 – 1730DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1642 – 1662Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1715 – 1730PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1090, Eukaryota
KOG4471, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002298_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KIK7

TreeFam database of animal gene trees

More...
TreeFami
TF318583

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13339, PH-GRAM_MTMR13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KIK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLADYFIV VGYDHEKTGS GEGLGKIIQR FPLKDLDDTP FPQGIELFCQ
60 70 80 90 100
PGGWHLSKER KQPTFFVVVL TDINSERHYC SCLTFYEAEI NLQGTRETEG
110 120 130 140 150
EEESGLIQPA EVFAPKSLVL VSRLDYPEIF RACLGLVYTV YVDNLNVSLE
160 170 180 190 200
NLIANLCSCF VPAAGGSQKL FSLGAGDRQM IQTPLHDSLP VTGTSVALLF
210 220 230 240 250
QQLGIQNVLS LFCAVLTENK VLFHSASFQR LSDACRALES LMFPLKYSYP
260 270 280 290 300
YIPILPAQLL EVLSSPTPFI IGVHSIFCNE IHELLDVIIA DLDGGTIKIP
310 320 330 340 350
ECIHLSPLPE PLLHQTQTAL SLVLHPDLET ADYAFPPPRT ALSQSKMLDK
360 370 380 390 400
EVRGVFLRLF AQLFQGYRSC LQLIRIHAEP VINFHKAAFL GQRGLIENDF
410 420 430 440 450
LTKVLNGMAF AGFVSERGPP YRSCDLFDEL VAFEVERIKS EESNSSKMLK
460 470 480 490 500
HVRELAEQLF KNENPNPHMA FQKVPRPTEG SHLRIHVLPF PKINENQVQD
510 520 530 540 550
LIQDGLVKNQ SVQPASRIEK KCVVPAGPPV VSIVEKSSSV FNSAQRLEVV
560 570 580 590 600
RNCISFIFEN KILETEKTLP AALRALKGKV ARQCLTEELS LHVQQNRAIL
610 620 630 640 650
DHQQFDYIVR MMNCTLQDCS TSEEYNIAAA LLPLTTAFYR KLAPGVSQFA
660 670 680 690 700
YTCVQDHPIW ANQQFWETTF YSDVENQIRS LYLSSKEDNH PQYLKQKENN
710 720 730 740 750
SEGNTQEKTA MDLAAEQLRL WPTLSKEIQQ QLVQSEESMV FSQAIHFANL
760 770 780 790 800
MVYLLVPLDT SKNKLLRTSA TGDWESGSNS IVTNSIAGSV AESYDTESGF
810 820 830 840 850
EDSENNDIAN AVVRFITRFI DKVCTESGVT QDHIRSLHCM IPGIVAMHIE
860 870 880 890 900
TLEAVHRESR RLPPIQKPKI LRPALLPGEE FVCEGLRVLL DPDGREEATG
910 920 930 940 950
GLLGGPHILP AEGALFLTTY RVIFKGTPHD QLVGEQTVIR SFPVSSITKE
960 970 980 990 1000
KKITIQNQLQ QNMQEGLQIT SAAFQLIKVA FDEEVGPEVV EIFKKQLMKF
1010 1020 1030 1040 1050
RYPQSIFSTF AFAAGQTAPQ IILPKQKEKN TSFRTLSKTI VKGAKRAGKM
1060 1070 1080 1090 1100
TIGRQYLLKK KTTGTIVEER ANRPGWNEDD DISVSDDSEM HTSGTLKASE
1110 1120 1130 1140 1150
KSTMEQLVER ACFRDYQRLG LGTINNSSTR SKTEYFRITA LNRMYSLCRS
1160 1170 1180 1190 1200
YPGLLVVPQC VQDSNLQRVA RCYRHNRLPV VCWKNSKSSA LLLRAGGFHG
1210 1220 1230 1240 1250
KGVVGLFKSQ NTQTSAPTSL ESSSSIEQEK YLQALLNAIS VHCKMNGNNT
1260 1270 1280 1290 1300
LTIRPTIALS PGVWASLRSS SRFISTQMPF LDVGARLAGK DGSPSYSSSN
1310 1320 1330 1340 1350
AYFQNRLTKR QASLYVFGEK SQLRGFKLDF ALNCEFVPVE FSDLRQVKTS
1360 1370 1380 1390 1400
FKKLMSACIP SSIPSDPEIT FLKALGESEW FPQLHRIMQL SVVMSELLEN
1410 1420 1430 1440 1450
GSSVLVCLED GWDITAQVVS LVQLLSDPFY RTLEGFRMLV EKEWLSFGHK
1460 1470 1480 1490 1500
FSQRSNLTLN CQGSGFAPVF LQFLDCVHQV HNQYPTEFEF NQYYLKFLAF
1510 1520 1530 1540 1550
HYVSNRFKTF LLDSDYERLE HGTLFEDKGE KHGKKGICMW ECIDKIHKRS
1560 1570 1580 1590 1600
PVFFNYLYTP VETEASFSQV LKPNVNISSL KKWDYYTEET LATGPSYDWT
1610 1620 1630 1640 1650
MIISKCSTLD EPDQRDESSS HSKRKIVWPC YDDINKVQPD AITNLLNEIE
1660 1670 1680 1690 1700
RLENKLHQNP ERWQQLWERI KVNVKEDTKQ DNHRRHPSGS SAVMSANLHS
1710 1720 1730 1740 1750
YQKRSLLHVP DSGLGEEQNA NNSPSNGVER RVTTLYNQFT SKNDENRSFE
1760 1770 1780 1790 1800
GTLYKRGALL KGWKPRWFVL DVTKHQLRYY DSVDDACCRG HIDLAEVESV
1810 1820 1830 1840 1850
IPASPTIGAP KHTNEKAFFD LKTSKRVYNF CAQEAQSAQQ WMDRIQSCIS

DA
Length:1,852
Mass (Da):209,279
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D68805A00D1A5AD
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000009189; ENSACAP00000008996; ENSACAG00000009005

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008996

Genome annotation databases

EnsembliENSACAT00000009189; ENSACAP00000008996; ENSACAG00000009005

Phylogenomic databases

eggNOGiKOG1090, Eukaryota
KOG4471, Eukaryota
GeneTreeiENSGT00940000155385
HOGENOMiCLU_002298_1_1_1
InParanoidiG1KIK7
TreeFamiTF318583

Gene expression databases

BgeeiENSACAG00000009005, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

CDDicd13339, PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KIK7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KIK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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