UniProtKB - G1KI54 (G1KI54_ANOCA)
Protein
Tyrosine-protein kinase
Gene
JAK1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.2UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 910 | ATPUniRule annotation | 1 | |
Active sitei | 1005 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 883 – 891 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- growth hormone receptor binding Source: GO_Central
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-UniRule
- protein phosphatase binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- interleukin-2-mediated signaling pathway Source: Ensembl
- intracellular signal transduction Source: InterPro
- positive regulation of homotypic cell-cell adhesion Source: Ensembl
- positive regulation of sprouting angiogenesis Source: Ensembl
- protein localization to cell-cell junction Source: Ensembl
- response to antibiotic Source: Ensembl
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:JAK1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: UniProtKB-UniRule
Nucleus
- nucleus Source: Ensembl
Other locations
Expressioni
Gene expression databases
Bgeei | ENSACAG00000008478, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- growth hormone receptor binding Source: GO_Central
- protein phosphatase binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008587 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 423 | FERMInterPro annotationAdd BLAST | 390 | |
Domaini | 586 – 857 | Protein kinaseInterPro annotationAdd BLAST | 272 | |
Domaini | 877 – 1155 | Protein kinaseInterPro annotationAdd BLAST | 279 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 336 – 359 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation
Keywords - Domaini
SH2 domainARBA annotationPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157092 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | G1KI54 |
OrthoDBi | 58906at2759 |
TreeFami | TF327041 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020776, Tyr_kinase_non-rcpt_Jak1 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01824, JANUSKINASE1 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KI54-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQYFNVKEDC KAMAFCAKMR SSKRNEVYIE NQEQGLELAF YLQEKPSLLY
60 70 80 90 100
TSGKYTAEEL CIEAAQKCSI SPLCHNLFAL FDESRSLWYA PNHIFQIDDK
110 120 130 140 150
TALRVHYRMR FYFSNWHGTN ENETPVWRHS SKKSKNSYEK KLVQEGTPLL
160 170 180 190 200
DAFSLEYLFA QGQNDLVRCF APVRDSKNDQ ETQEIQNECL GMAVLAITHY
210 220 230 240 250
AIKKNLRLPE LLRDISYKRY IPESLNKTIK QKNLLTRIRI NNVFKDFLKE
260 270 280 290 300
FNKRTICDSS VSPHDLKVKY LSTMETLTKH YGAELFETTS LLISSENEKS
310 320 330 340 350
FNMDDCNIIP HYEVIVTGNQ GIQWRVKPYG SMLQVTQTEK EKHKTKRKKS
360 370 380 390 400
DGKVKKNEEK SKREDWNNFS YFPEITHLVI KESTVSVYKQ DNKRMELKLS
410 420 430 440 450
SHGEALSFAA LVDGYFRLTT DAHHYLCTDV APPLIEHNIK NGCHGPICTD
460 470 480 490 500
YAVNKLKQEG NEEGMYVLRW SCTDFNNILL TVVCTEGSQQ FLNPLKQYKN
510 520 530 540 550
FQIEMKKNGC LLHGSDKFFS SLKELMDHLK GQILRTDNIE FTLKQCCQPK
560 570 580 590 600
PKEISNLLVA TKLSQECKPI YPLSQLSFHQ IRKEEIIQGE HLGRGTKTQI
610 620 630 640 650
YSGILNYKDD ESYQSEKEIK VLLKVLDPNH RDISLAFFET ASMMRQISHK
660 670 680 690 700
HIVLLHGICV RDVENIMVEE YVEFGPLDLF MRRKSVLLTT PWKFKVAKQL
710 720 730 740 750
ASALSYLEDK DLVHGNVCTK NILLAREGID NEYGPFIKLS DPGISVTVLS
760 770 780 790 800
KQECVERIPW LAPECVKDSK NLSVAADKWS FGTTLWEICY NGEIPLKDKT
810 820 830 840 850
LAEKERFYDG HFTLRTPSCK ELADLMKQCM HYDPNQRPFF RAIMRDINKL
860 870 880 890 900
EEQNPEIVSE KKPNDDVDPT VFEKRFLKRI RDLGEGHFGK VELCRYDPEG
910 920 930 940 950
DNTGEQVAVK SLKPDCGGNH IADLKKEIEI LRNLYHENIV KYKGICTEDG
960 970 980 990 1000
GNGIKLIMEF LPSGSLKEYL PRNRNKICLK QQLKYAVQIC KGMDYLGSRQ
1010 1020 1030 1040 1050
YVHRDLAARN VLVENEQRVK IGDFGLTKTI ETDKEYYKVN DDRDSPVFWY
1060 1070 1080 1090 1100
APECLLQSKF YIASDVWSFG VTLYELLTYC DSECSPMAEF LKMIGPTQGQ
1110 1120 1130 1140 1150
MTVTRLVRIL GEGKRLPCPK SCPEEVNHLM RRCWVHDPGE RTTFHNLIQG
FEEFMKKM
Sequence databases
RefSeqi | XP_008107519.1, XM_008109312.2 |
Genome annotation databases
Ensembli | ENSACAT00000008770; ENSACAP00000008587; ENSACAG00000008478 |
GeneIDi | 100559328 |
KEGGi | acs:100559328 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008107519.1, XM_008109312.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008587 |
Genome annotation databases
Ensembli | ENSACAT00000008770; ENSACAP00000008587; ENSACAG00000008478 |
GeneIDi | 100559328 |
KEGGi | acs:100559328 |
Organism-specific databases
CTDi | 3716 |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157092 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | G1KI54 |
OrthoDBi | 58906at2759 |
TreeFami | TF327041 |
Gene expression databases
Bgeei | ENSACAG00000008478, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020776, Tyr_kinase_non-rcpt_Jak1 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01824, JANUSKINASE1 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KI54_ANOCA | |
Accessioni | G1KI54Primary (citable) accession number: G1KI54 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |