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Entry version 68 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

ARHGAP21

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000008596, Expressed in brain and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000008451

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 160PDZInterPro annotationAdd BLAST110
Domaini947 – 1056PHInterPro annotationAdd BLAST110
Domaini1169 – 1361Rho-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 41DisorderedSequence analysisAdd BLAST23
Regioni215 – 243DisorderedSequence analysisAdd BLAST29
Regioni336 – 385DisorderedSequence analysisAdd BLAST50
Regioni432 – 451DisorderedSequence analysisAdd BLAST20
Regioni477 – 496DisorderedSequence analysisAdd BLAST20
Regioni738 – 764DisorderedSequence analysisAdd BLAST27
Regioni880 – 902DisorderedSequence analysisAdd BLAST23
Regioni922 – 941DisorderedSequence analysisAdd BLAST20
Regioni1079 – 1098DisorderedSequence analysisAdd BLAST20
Regioni1105 – 1146DisorderedSequence analysisAdd BLAST42
Regioni1392 – 1424DisorderedSequence analysisAdd BLAST33
Regioni1437 – 1534DisorderedSequence analysisAdd BLAST98
Regioni1625 – 1660DisorderedSequence analysisAdd BLAST36
Regioni1675 – 1700DisorderedSequence analysisAdd BLAST26
Regioni1722 – 1743DisorderedSequence analysisAdd BLAST22
Regioni1760 – 1779DisorderedSequence analysisAdd BLAST20
Regioni1796 – 1823DisorderedSequence analysisAdd BLAST28
Regioni1881 – 1947DisorderedSequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 240Polar residuesSequence analysisAdd BLAST17
Compositional biasi479 – 496Polar residuesSequence analysisAdd BLAST18
Compositional biasi738 – 755Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1115 – 1142Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1398 – 1422Polar residuesSequence analysisAdd BLAST25
Compositional biasi1449 – 1511Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi1634 – 1656Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1675 – 1693Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1902 – 1934Polar residuesSequence analysisAdd BLAST33

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4407, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155406

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001776_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KHZ9

Database of Orthologous Groups

More...
OrthoDBi
142586at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820, PDZ_6, 1 hit
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KHZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRWAEGGD GREALARSFS QVSKNKDGKE QSEAVSLSED EEAFSWPGPK
60 70 80 90 100
TVVLQRTSQG FGFTLRHFIV YPPESAVQFS FKDEENGNKG GKPRNKLEPM
110 120 130 140 150
DTIFVKQVKE GGPAFEAGLC TGDRIIKVNG ESVIGKTYSQ VIALIQNSDS
160 170 180 190 200
ILELSVMPKD EDILQLLQFS KDVTALAYSQ DAYLKGNEAY SGNAGNIPEP
210 220 230 240 250
PPICYPRLTS PATGMAQPIE KASPDSAQRK QTTSKPVRTS AQPEKAYRME
260 270 280 290 300
IQVPPSPTDV AKSNTAVCVC NETVKTVVVP SEKAVDFSLC RTNHTTPSHR
310 320 330 340 350
IEELSYGFKE QATPKTKART TSPSSSMSTA IVLPQTPLTR PVDPSGITNT
360 370 380 390 400
SGTFGRHPEE VTTTRSPTRS VGSPSITTNH YTSPNAHQHI DWKNYKTYKE
410 420 430 440 450
YIDNRRLQMY GCRTIQERLD SLRAASQNTT DYNQMVPNRT GSQVRRRSTS
460 470 480 490 500
HDRVLPAIQV RQKSASQERL EDPNVVLNEW PRSASQDALT SPPLSPRNYR
510 520 530 540 550
TRSWDYLGKQ GDTIENLHAD NFVGDPNRDK KKTYQWTGFT EQDDRRGFHE
560 570 580 590 600
RTRLQAFHLS FRGSKFFGAP GAYNPDGRLI SNRALGSAPH FQKISPDGKT
610 620 630 640 650
LQPVRNLPAA GGTSKPATIF QERLSHSTAR STRSNSLKTS IPYAAKPSLP
660 670 680 690 700
LNQSLDSVTT RNQRAVNDVH HSSLFNQQSR IHAESVPDRK VDLGKSTLSP
710 720 730 740 750
TSCIASAKFV PQMSEHLTTS VSLDVSVRQK VRDFEKEDEI RPSHVDQETE
760 770 780 790 800
TVVLREKSPS GHQTPQLLRH QSYILAVNDP EPASETTCWL PNDARREVHI
810 820 830 840 850
KRIEERKASS SSPPGDSLAS IPFIDEPASP STDHDIAHIP ASAVISASSS
860 870 880 890 900
RAPTITTVPP SPTSLVPLIR RQLSHDHESI RASIVDGQFP TKSERSKSYD
910 920 930 940 950
EGLDDYREGK VAIKHVSSLK GIKAPDSQTS SENSGSRKAS SSEIFGDASK
960 970 980 990 1000
VGWLYFRQLV TDKGKRVGGS IRPWKQMHVV LKGCSLYLYK DKKEQVVPSE
1010 1020 1030 1040 1050
EEQPISINAC LIDISYSDTK RKHVFRLTTS DCEYLFQAED RDDMLAWIRA
1060 1070 1080 1090 1100
IQENSNLNTE NTGVTSRDLI SRRIKEYSTM MSASSGKTEP SPKPSRQGLS
1110 1120 1130 1140 1150
IRQTLLGNKT ESRTQSPHSP KEESERKFLG KEKDETSPPK DKGTWRKTIP
1160 1170 1180 1190 1200
NIMRKTFEKK PSAVGTFGVR LDDCPPAQSN KYIPLIVDVC CKIVEERGLE
1210 1220 1230 1240 1250
YTGIYRVPGN NAAISSMQEE LNKGMTDIDV QDDKWRDLNV ISSLLKSFFR
1260 1270 1280 1290 1300
KLPEPLFTND KYGDFIDANR REDPVERLKT LKRLIRDLPE HHYETLKFLS
1310 1320 1330 1340 1350
AHLKTVAENS EKNKMEPRNL AIVFGPTLVR TSEDNMTHMV THMPDQYKIV
1360 1370 1380 1390 1400
ETLIQKHDWF FAEDDAEEPL TAVQEENTVQ SQPVPNIDHL LTNIGRTGVS
1410 1420 1430 1440 1450
PGDVSDSTTS DSAKSKGSWG SGKDQYSKEL LKSSIFAAAS RKRKKPKEKP
1460 1470 1480 1490 1500
QPSSSEDEFD SVFYKKESVE HCHDSSAKEE AQKEDPEKET ARRKLRTTVP
1510 1520 1530 1540 1550
KEKENNNKKM PTGTKDEILP VKEGLTSEDP STPYLQKYVR SPNLSFRLST
1560 1570 1580 1590 1600
PKACIKSPVL HISSQIEETI SDSGTILSSS SQASLQKFPS KKLASEFLEA
1610 1620 1630 1640 1650
DVNSITSDYS TISSATYLTG LDSTMLTPES VTGSKGEEAD DERSELISEG
1660 1670 1680 1690 1700
RPVETDSESD FSVFAASSAV ERLFRGKRQD VSKGSRRNSE ESEVSCTEGS
1710 1720 1730 1740 1750
LTPKLDSRRL FSSHKLIECD TLSRRKSARQ KTDSEGSGDA KCEKESLAVT
1760 1770 1780 1790 1800
KMFDIMKKGK STGSLAAVSK SEPEKQEPTW RLKITDRLKQ RLKSSADDMF
1810 1820 1830 1840 1850
GVGNQKSNST EISKRKNIRR RHTLGGQRDF AEISVLNAWK AQEKNPSREK
1860 1870 1880 1890 1900
DISAVDRLKP KCPVQDLSIS GWLAQERLQT STTELKTGES GEPKKGKTSR
1910 1920 1930 1940 1950
LADLSEPSSS AETWAEEGGS SSSSSLTLVS RAPVSGQLQP LDHVNGESYQ
1960 1970 1980
SMNRNNFSPT IDAHPHKLSG NQVVRSRFYQ FL
Length:1,982
Mass (Da):220,583
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03BA9A6C2FF3C559
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008110612.1, XM_008112405.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000008633; ENSACAP00000008451; ENSACAG00000008596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100552200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008110612.1, XM_008112405.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008451

Genome annotation databases

EnsembliENSACAT00000008633; ENSACAP00000008451; ENSACAG00000008596
GeneIDi100552200

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57584

Phylogenomic databases

eggNOGiKOG4407, Eukaryota
GeneTreeiENSGT00940000155406
HOGENOMiCLU_001776_0_0_1
InParanoidiG1KHZ9
OrthoDBi142586at2759
TreeFamiTF329345

Gene expression databases

BgeeiENSACAG00000008596, Expressed in brain and 14 other tissues

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF17820, PDZ_6, 1 hit
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KHZ9_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KHZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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