UniProtKB - G1KHX9 (G1KHX9_ANOCA)
Protein
6-O-methylguanine-DNA methyltransferase
Gene
MGMT
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]ARBA annotationEC:2.1.1.63ARBA annotation
- a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]ARBA annotationEC:2.1.1.63ARBA annotation
GO - Molecular functioni
- methylated-DNA-[protein]-cysteine S-methyltransferase activity Source: GO_Central
GO - Biological processi
- DNA dealkylation involved in DNA repair Source: Ensembl
- DNA repair Source: GO_Central
- methylation Source: UniProtKB-KW
- regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Keywordsi
Molecular function | MethyltransferaseARBA annotation, Transferase |
Biological process | DNA damage, DNA repairARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: 6-O-methylguanine-DNA methyltransferaseARBA annotation (EC:2.1.1.63ARBA annotation)Alternative name(s): Methylated-DNA--protein-cysteine methyltransferaseARBA annotation O-6-methylguanine-DNA-alkyltransferaseARBA annotation |
Gene namesi | Name:MGMTImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000008585, Expressed in liver and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 118 | DNA_binding_1InterPro annotationAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the MGMT family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG4062, Eukaryota |
GeneTreei | ENSGT00390000015799 |
HOGENOMi | CLU_000445_52_4_1 |
InParanoidi | G1KHX9 |
TreeFami | TF314064 |
Family and domain databases
CDDi | cd06445, ATase, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001497, MethylDNA_cys_MeTrfase_AS IPR014048, MethylDNA_cys_MeTrfase_DNA-bd IPR036217, MethylDNA_cys_MeTrfase_DNAb IPR036631, MGMT_N_sf IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01035, DNA_binding_1, 1 hit |
SUPFAMi | SSF46767, SSF46767, 1 hit SSF53155, SSF53155, 1 hit |
TIGRFAMsi | TIGR00589, ogt, 1 hit |
PROSITEi | View protein in PROSITE PS00374, MGMT, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KHX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEPLKQCTA WLQAYFCEPQ MIEKLPIPPF HHPLFEHASF TREVLWTLLR
60 70 80 90 100
DVKFGEAISY KQLADLAGNS KAARAVGGAM RRNPVPIIIP CHRVICSGGQ
110
TGNYTGGSHL KEWLLSHE
Genome annotation databases
Ensembli | ENSACAT00000008565; ENSACAP00000008384; ENSACAG00000008585 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008384 |
Genome annotation databases
Ensembli | ENSACAT00000008565; ENSACAP00000008384; ENSACAG00000008585 |
Phylogenomic databases
eggNOGi | KOG4062, Eukaryota |
GeneTreei | ENSGT00390000015799 |
HOGENOMi | CLU_000445_52_4_1 |
InParanoidi | G1KHX9 |
TreeFami | TF314064 |
Gene expression databases
Bgeei | ENSACAG00000008585, Expressed in liver and 14 other tissues |
Family and domain databases
CDDi | cd06445, ATase, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001497, MethylDNA_cys_MeTrfase_AS IPR014048, MethylDNA_cys_MeTrfase_DNA-bd IPR036217, MethylDNA_cys_MeTrfase_DNAb IPR036631, MGMT_N_sf IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01035, DNA_binding_1, 1 hit |
SUPFAMi | SSF46767, SSF46767, 1 hit SSF53155, SSF53155, 1 hit |
TIGRFAMsi | TIGR00589, ogt, 1 hit |
PROSITEi | View protein in PROSITE PS00374, MGMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KHX9_ANOCA | |
Accessioni | G1KHX9Primary (citable) accession number: G1KHX9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | October 7, 2020 | |
This is version 52 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |