UniProtKB - G1KHR4 (G1KHR4_ANOCA)
Protein
Collectin-12
Gene
COLEC12
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- low-density lipoprotein particle binding Source: Ensembl
- pattern recognition receptor activity Source: Ensembl
- scavenger receptor activity Source: Ensembl
- signaling receptor activity Source: GO_Central
GO - Biological processi
- cellular response to exogenous dsRNA Source: Ensembl
- defense response to bacterium Source: Ensembl
- immune response Source: Ensembl
- phagocytosis, recognition Source: Ensembl
- positive regulation of cell adhesion molecule production Source: Ensembl
- toll-like receptor 3 signaling pathway Source: Ensembl
Keywordsi
Ligand | CalciumARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Collectin-12ARBA annotation |
Gene namesi | Name:COLEC12Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- collagen trimer Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 38 – 59 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Membrane, SecretedARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000008396, Expressed in embryo and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 608 – 725 | C-type lectinInterPro annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 439 – 592 | DisorderedSequence analysisAdd BLAST | 154 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 206 – 254 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 304 – 324 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 575 – 590 | Pro-richSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coilSequence analysis, CollagenARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QQKQ, Eukaryota |
GeneTreei | ENSGT00950000183074 |
HOGENOMi | CLU_022132_0_0_1 |
InParanoidi | G1KHR4 |
OrthoDBi | 565046at2759 |
TreeFami | TF332426 |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR008160, Collagen IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01391, Collagen, 3 hits PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KHR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDDFTEEDE VQSFGYKRFG IQEGTQCTKC KSNWALKFSI ILLYILCALL
60 70 80 90 100
TITVAILGYK VVEKMDNVTV GLESSHRRYN DKLTDVESDL KKLDYKAGEK
110 120 130 140 150
ALSTNTELSS FKDDILALRQ QLHEISDKTA KNKDTLEKLQ ESGSVLDDRQ
160 170 180 190 200
SQMKGVLDSN SFMIASVNKT LQAYSGYVND LQEDTNKIQT TLQSQMHSHS
210 220 230 240 250
VVIMNLNNLN QTQAQQRDLI NALQRSVDDT SQAIQRIKSD FQNLQQVALQ
260 270 280 290 300
ARKDTDWLKE KVQNLQALAA NNSVLAKANN DTLEDMNSQL NSFSGQMENI
310 320 330 340 350
TTIAQANEQS LKELQEHHKE YENGTTARFN QQENRFQSFE TDIVNIISNI
360 370 380 390 400
SYTAHHLRTL TSNLNDVRTT CTDTLSKHTD ELTFMNNTLA NIRLDATTLR
410 420 430 440 450
MQQDVMRSRL DNEVANLSII MEEMKLVDSK HGQLIKNFTI LQGPPGPRGP
460 470 480 490 500
KGDRGPQGPI GLTGPKGQKG DKGEPGPPGP QGEKGPSGPV GPPGEKGGKG
510 520 530 540 550
SRGSPGSKGQ RGSTGKTGLP GPSGEPGPPG LPGKDGPPGL QGQPGPQGLP
560 570 580 590 600
GIPGLTGIPG SRGLPGLPGT PGPRGLQGQP GPPGPPGPGL PVALQSETNG
610 620 630 640 650
CPVYWNNFSG NCYYFSTERA IFEDARLFCE EKASHLVFIN NETEQEWLKK
660 670 680 690 700
QVVAKGSFWI GLTDSAKENE WRWLDGTLPE YVNWSAGQPD NWKHGHGPGE
710 720 730
DCAGLIHAGL WNDFYCEDVN SFICEQEADK AQAPGL
Sequence databases
RefSeqi | XP_008106857.1, XM_008108650.2 |
Genome annotation databases
Ensembli | ENSACAT00000008416; ENSACAP00000008239; ENSACAG00000008396 |
GeneIDi | 100563402 |
KEGGi | acs:100563402 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008106857.1, XM_008108650.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008239 |
Genome annotation databases
Ensembli | ENSACAT00000008416; ENSACAP00000008239; ENSACAG00000008396 |
GeneIDi | 100563402 |
KEGGi | acs:100563402 |
Organism-specific databases
CTDi | 81035 |
Phylogenomic databases
eggNOGi | ENOG502QQKQ, Eukaryota |
GeneTreei | ENSGT00950000183074 |
HOGENOMi | CLU_022132_0_0_1 |
InParanoidi | G1KHR4 |
OrthoDBi | 565046at2759 |
TreeFami | TF332426 |
Gene expression databases
Bgeei | ENSACAG00000008396, Expressed in embryo and 14 other tissues |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR008160, Collagen IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01391, Collagen, 3 hits PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KHR4_ANOCA | |
Accessioni | G1KHR4Primary (citable) accession number: G1KHR4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |